Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-10

AUTHORS

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov, Richard A. Flavell

ABSTRACT

Toll-like receptors (TLRs) are a family of innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, and induce antimicrobial immune responses. Double-stranded RNA (dsRNA) is a molecular pattern associated with viral infection, because it is produced by most viruses at some point during their replication. Here we show that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-kappaB and the production of type I interferons (IFNs). TLR3-deficient (TLR3-/-) mice showed reduced responses to polyinosine-polycytidylic acid (poly(I:C)), resistance to the lethal effect of poly(I:C) when sensitized with d-galactosamine (d-GalN), and reduced production of inflammatory cytokines. MyD88 is an adaptor protein that is shared by all the known TLRs. When activated by poly(I:C), TLR3 induces cytokine production through a signalling pathway dependent on MyD88. Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature. More... »

PAGES

732

Journal

TITLE

Nature

ISSUE

6857

VOLUME

413

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35099560

    DOI

    http://dx.doi.org/10.1038/35099560

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031094923

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11607032


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    Download the RDF metadata as:  json-ld nt turtle xml License info

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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35099560'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35099560'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35099560'

    RDF/XML is a standard XML format for linked data.

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