Evolution and transmission of stable CTL escape mutations in HIV infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-07

AUTHORS

Philip J. R. Goulder, Christian Brander, Yanhua Tang, Cecile Tremblay, Robert A. Colbert, Marylyn M. Addo, Eric S. Rosenberg, Thi Nguyen, Rachel Allen, Alicja Trocha, Marcus Altfeld, Suqin He, Michael Bunce, Robert Funkhouser, Stephen I. Pelton, Sandra K. Burchett, Kenneth McIntosh, Bette T. M. Korber, Bruce D. Walker

ABSTRACT

Increasing evidence indicates that potent anti-HIV-1 activity is mediated by cytotoxic T lymphocytes (CTLs)1,2,3; however, the effects of this immune pressure on viral transmission and evolution have not been determined. Here we investigate mother–child transmission in the setting of human leukocyte antigen (HLA)-B27 expression, selected for analysis because it is associated with prolonged immune containment in adult infection4. In adults, mutations in a dominant and highly conserved B27-restricted Gag CTL epitope lead to loss of recognition and disease progression4,5,6. In mothers expressing HLA-B27 who transmit HIV-1 perinatally, we document transmission of viruses encoding CTL escape variants in this dominant Gag epitope that no longer bind to B27. Their infected infants target an otherwise subdominant B27-restricted epitope and fail to contain HIV replication. These CTL escape variants remain stable without reversion in the absence of the evolutionary pressure that originally selected the mutation. These data suggest that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design. More... »

PAGES

334-338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35085576

DOI

http://dx.doi.org/10.1038/35085576

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005637789

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11460164


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