A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Hernando A. del Portillo, Carmen Fernandez-Becerra, Sharen Bowman, Karen Oliver, Martin Preuss, Cecilia P. Sanchez, Nick K. Schneider, Juan M. Villalobos, Marie-Adele Rajandream, David Harris, Luiz H. Pereira da Silva, Bart Barrell, Michael Lanzer

ABSTRACT

The malarial parasite Plasmodium vivax causes disease in humans, including chronic infections and recurrent relapses, but the course of infection is rarely fatal, unlike that caused by Plasmodium falciparum. To investigate differences in pathogenicity between P. vivax and P. falciparum, we have compared the subtelomeric domains in the DNA of these parasites. In P. falciparum, subtelomeric domains are conserved and contain ordered arrays of members of multigene families, such as var, rif and stevor, encoding virulence determinants of cytoadhesion and antigenic variation. Here we identify, through the analysis of a continuous 155,711-base-pair sequence of a P. vivax chromosome end, a multigene family called vir, which is specific to P. vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation. More... »

PAGES

839

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35071118

DOI

http://dx.doi.org/10.1038/35071118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049668505

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11298455


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35071118'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35071118'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35071118'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35071118'


 

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