Substeps within the 8-nm step of the ATPase cycle of single kinesin molecules View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03-19

AUTHORS

Masayoshi Nishiyama, Etsuko Muto, Yuichi Inoue, Toshio Yanagida, Hideo Higuchi

ABSTRACT

Kinesin is a molecular motor that moves processively1,2,3,4 by regular 8-nm steps along microtubules5,6,7,8,9,10,11. The processivity of this movement is explained by a hand-over-hand model in which the two heads of kinesin work in a coordinated manner. One head remains bound to the microtubule while the other steps from the αβ-tubulin dimer behind the attached head to the dimer in front. The overall movement is 8 nm per ATPase cycle9,10,11,12,13. To investigate elementary processes within the 8-nm step, we have developed a new assay that resolves nanometre displacements of single kinesin molecules with microsecond accuracy. Our data show that the 8-nm step can be resolved into fast and slow substeps, each corresponding to a displacement of ∼4 nm. The substeps are most probably generated by structural changes in one head of kinesin, leading to rectified forward thermal motions of the partner head14. It is also possible that the kinesin steps along the 4-nm repeat of tubulin monomers. More... »

PAGES

425-428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35070116

DOI

http://dx.doi.org/10.1038/35070116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013641175

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11283618


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187 Single Molecule Processes Project, ICORP, JST, 2-4-14, Senba-Higashi, 562-0035, Mino, Osaka, Japan
188 rdf:type schema:Organization
189 grid-institutes:grid.136593.b schema:alternateName Department of Biophysical Engineering, Osaka University 1-3, Machikaneyama, 560-8531, Toyonaka, Osaka, Japan
190 Department of Physiology and Biosignaling, Graduate School of Medicine, Osaka University 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan
191 schema:name Department of Biophysical Engineering, Osaka University 1-3, Machikaneyama, 560-8531, Toyonaka, Osaka, Japan
192 Department of Physiology and Biosignaling, Graduate School of Medicine, Osaka University 2-2, Yamadaoka, 565-0871, Suita, Osaka, Japan
193 Single Molecule Processes Project, ICORP, JST, 2-4-14, Senba-Higashi, 562-0035, Mino, Osaka, Japan
194 rdf:type schema:Organization
195 grid-institutes:grid.69566.3a schema:alternateName Center of Interdisciplinary Research, Tohoku University, 980-8579, Sendai, Japan
196 schema:name Center of Interdisciplinary Research, Tohoku University, 980-8579, Sendai, Japan
197 Department of Metallurgy, Graduate School of Engineering, Tohoku University, 980-8579, Sendai, Japan
198 rdf:type schema:Organization
 




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