High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-04

AUTHORS

B L Hempstead, D Martin-Zanca, D R Kaplan, L F Parada, M V Chao

ABSTRACT

Nerve growth factor (NGF) interacts with two different low-affinity receptors that can be distinguished by affinity crosslinking. Reconstitution experiments by membrane fusion and transient transfection into heterologous cells indicate that high-affinity NGF binding requires coexpression and binding to both the low-affinity NGF receptor and the tyrosine kinase trk gene product. These studies reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor. More... »

PAGES

678-683

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/350678a0

DOI

http://dx.doi.org/10.1038/350678a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005148760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1850821


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