Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Sameez Hasan, Paul O. Hassa, Ralph Imhof, Michael O. Hottiger

ABSTRACT

The transcriptional coactivator p300 interacts with many transcription factors that participate in a broad spectrum of biological activities, such as cellular differentiation, homeostasis and growth control. Mouse embryos lacking both p300 alleles die around mid-gestation, with pleiotropic defects in morphogenesis, in cell differentiation and, unexpectedly, in cell proliferation because of reduced DNA synthesis. Here we show that p300 may have a role in DNA repair synthesis through its interaction with proliferating cell nuclear antigen (PCNA). We show that in vitro and in vivo p300 forms a complex with PCNA that does not depend on the S phase of cell cycle. A large fraction of both p300 and PCNA colocalize to speckled structures in the nucleus. Furthermore, the endogenous p300-PCNA complex stimulates DNA synthesis in vitro. Chromatin immunoprecipitation experiments indicate that p300 is associated with freshly synthesized DNA after ultraviolet irradiation. Our results suggest that p300 may participate in chromatin remodelling at DNA lesion sites to facilitate PCNA function in DNA repair synthesis. More... »

PAGES

387

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35066610

DOI

http://dx.doi.org/10.1038/35066610

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029283585

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11268218


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