Chromosome territories, nuclear architecture and gene regulation in mammalian cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

T Cremer, C Cremer

ABSTRACT

The expression of genes is regulated at many levels. Perhaps the area in which least is known is how nuclear organization influences gene expression. Studies of higher-order chromatin arrangements and their dynamic interactions with other nuclear components have been boosted by recent technical advances. The emerging view is that chromosomes are compartmentalized into discrete territories. The location of a gene within a chromosome territory seems to influence its access to the machinery responsible for specific nuclear functions, such as transcription and splicing. This view is consistent with a topological model for gene regulation. More... »

PAGES

292-301

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35066075

    DOI

    http://dx.doi.org/10.1038/35066075

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000190833

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11283701


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