Skewed maturation of memory HIV-specific CD8 T lymphocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Patrick Champagne, Graham S. Ogg, Abigail S. King, Christian Knabenhans, Kim Ellefsen, Massimo Nobile, Victor Appay, G. Paolo Rizzardi, Sylvain Fleury, Martin Lipp, Reinhold Förster, Sarah Rowland-Jones, Rafick-P. Sékaly, Andrew J. McMichael, Giuseppe Pantaleo

ABSTRACT

Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the chemokine receptor CCR7, which defines distinct subsets of naive and memory T lymphocytes with different homing and effector capacities1,2,3 and antiviral immune responses to HIV and cytomegalovirus. Ex vivo analysis of the expression of CD45RA and CCR7 antigens, together with in vitro analysis of the cell-division capacity of different memory CD8+ T-cell populations, identified four subsets of HIV- and CMV-specific CD8+ T lymphocytes, and indicated the following lineage differentiation pattern: CD45RA+CCR7+ → CD45RA-CCR7+ → CD45RACD45RA-CCR7- → CD45RA+CCR7-. Here we demonstrate through analysis of cell division (predominantly restricted to the CCR7+CD8+ T-cell subsets) that the differentiation of antigen-specific CD8+ T cells is a two-step process characterized initially by a phase of proliferation largely restricted to the CCR7+CD8+ cell subsets, followed by a phase of functional maturation encompassing the CCR7-CD8+ cell subsets. The distribution of these populations in HIV- and CMV-specific CD8+ T cells showed that the HIV-specific cell pool was predominantly (70%) composed of pre-terminally differentiated CD45RA-CCR7- cells, whereas the CMV-specific cell pool consisted mainly (50%) of the terminally differentiated CD45RA+CCR7- cells. These results demonstrate a skewed maturation of HIV-specific memory CD8+ T cells during HIV infection. More... »

PAGES

106-111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35065118

DOI

http://dx.doi.org/10.1038/35065118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046408779

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11242051


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curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35065118'

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curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35065118'


 

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