Mammalian MAP kinase signalling cascades View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Lufen Chang, Michael Karin

ABSTRACT

Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death. More... »

PAGES

37

Journal

TITLE

Nature

ISSUE

6824

VOLUME

410

Related Patents

  • Protein Kinase Targeted Therapeutics
  • Increasing Life Span By Modulation Of Smek
  • Compositions, Methods, And Kits For Regulating Energy Metabolism
  • Compositions And Methods For Modulating Metabolic Pathways
  • Compositions And Methods For The Reduction Or Prevention Of Hepatic Steatosis
  • Compositions, Methods, And Kits For Regulating Energy Metabolism
  • Compositions, Methods, And Kits For Regulating Energy Metabolism
  • Protein Kinase Targeted Therapeutics
  • Methods For Managing Adverse Events In Patient Populations Requiring Transfusion
  • Identification Of Novel Factors That Block Programmed Cell Death Or Apoptosis By Targeting Jnk
  • Compositions And Methods For Modulating Metabolic Pathways
  • Polynucleotides Encoding The Novel Human Phosphatase, Ret31, And Variants Thereof
  • Microfluidic Device For Immunoblotting
  • Compositions And Methods For Modulating Metabolic Pathways
  • Identification Of Novel Factors That Block Programmed Cell Death Or Apoptosis By Targeting Jnk
  • Human Phosphatase Ret31, And Variants Thereof
  • Compositions And Methods For Modulating Metabolic Pathways
  • Compositions And Methods For Modulating Metabolic Pathways
  • Compositions And Methods For Increasing Energy Metabolism
  • Modulators Of Paraptosis And Related Methods
  • Increasing Life Span By Modulation Of Smek
  • Estrogen Antagonists As Treatments For Sclerosing Disorders
  • Compositions, Methods And Kits For Reducing Lipid Levels
  • Estrogen Antagonists As Treatments For Sclerosing Disorders
  • Compositions, Methods, And Kits For Regulating Energy Metabolism
  • Compositions And Methods For The Reduction Or Prevention Of Hepatic Steatosis
  • Compositions And Methods For Modulating Metabolic Pathways
  • Method Of Preparing Apoptotic Monocytes
  • Compositions And Methods For Modulating Metabolic Pathways
  • Compositions, Methods And Kits For Reducing Lipid Levels
  • Compositions And Methods For Modulating Metabolic Pathways
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35065000

    DOI

    http://dx.doi.org/10.1038/35065000

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029421135

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11242034


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MAP Kinase Signaling System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mammals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitogen-Activated Protein Kinase Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Substrate Specificity", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Lufen", 
            "id": "sg:person.01175630061.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175630061.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, San Diego", 
              "id": "https://www.grid.ac/institutes/grid.266100.3", 
              "name": [
                "Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karin", 
            "givenName": "Michael", 
            "id": "sg:person.0706540600.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00027-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000558502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.17.5037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002109213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.1.751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002493528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81767-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002656663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.1.321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002839988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009130897", 
              "https://doi.org/10.1038/6854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009130897", 
              "https://doi.org/10.1038/6854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/365179a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009910352", 
              "https://doi.org/10.1038/365179a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010185178", 
              "https://doi.org/10.1038/35002111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35002111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010185178", 
              "https://doi.org/10.1038/35002111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90402-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012072151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(99)80065-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014242834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.21.3369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015090406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.24.6742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015235035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.3.317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018306000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35011091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018609726", 
              "https://doi.org/10.1038/35011091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35011091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018609726", 
              "https://doi.org/10.1038/35011091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(05)00014-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018779619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80727-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019812256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0925-4773(99)00213-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022839551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80640-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023543830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80567-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023590652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373620a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024659816", 
              "https://doi.org/10.1038/373620a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.6.941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024792548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5383.1671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025126757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.1.270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026295363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.20.12.4265-4274.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026500080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.10.5243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027471800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1999.4687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029427955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/385544a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031372205", 
              "https://doi.org/10.1038/385544a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035322653", 
              "https://doi.org/10.1038/39899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/39899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035322653", 
              "https://doi.org/10.1038/39899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(96)80067-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036309979"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.12.6881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042140977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.23.12655", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042256547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81999-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044894434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.7.1845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047311018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047914855", 
              "https://doi.org/10.1038/10061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047914855", 
              "https://doi.org/10.1038/10061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(99)80164-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048205266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35000065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050094560", 
              "https://doi.org/10.1038/35000065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35000065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050094560", 
              "https://doi.org/10.1038/35000065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/386296a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050357476", 
              "https://doi.org/10.1038/386296a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90056-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052300306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5443.1374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052331127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)00193-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053689810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.270.5240.1326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062551677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5253.1272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5383.1668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5395.1911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5396.2092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5443.1358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5443.1362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5443.1365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.288.5467.870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062569393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7992057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/stke.2000.40.re1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062689924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074642264", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-03", 
        "datePublishedReg": "2001-03-01", 
        "description": "Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/35065000", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6824", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "410"
          }
        ], 
        "name": "Mammalian MAP kinase signalling cascades", 
        "pagination": "37", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8c2837ccbd42232d6fefebe73e7d79db28d8745c19f832ba50c59cc8e4a38247"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11242034"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/35065000"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1029421135"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/35065000", 
          "https://app.dimensions.ai/details/publication/pub.1029421135"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:21", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/35065000"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35065000'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35065000'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35065000'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35065000'


     

    This table displays all metadata directly associated to this object as RDF triples.

    269 TRIPLES      21 PREDICATES      88 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/35065000 schema:about N092b7a9191964c45a2210d9c498712ce
    2 N41f9cd9045f141e19fa75101857e41bc
    3 N45680a883c8d429eaa222f82d41edfb9
    4 N5a7dab8f0f8342eab1e4905cd53647dc
    5 N892060fd01cc4051b5535c30103c9d7c
    6 N91a2ae92657045c6828cd912a030a2d2
    7 N9933a1095de14845a320b130b76b389c
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author N7b5aec050eef4a4487c5fba9ffb077c3
    11 schema:citation sg:pub.10.1038/10061
    12 sg:pub.10.1038/35000065
    13 sg:pub.10.1038/35002111
    14 sg:pub.10.1038/35011091
    15 sg:pub.10.1038/365179a0
    16 sg:pub.10.1038/373620a0
    17 sg:pub.10.1038/385544a0
    18 sg:pub.10.1038/386296a0
    19 sg:pub.10.1038/39899
    20 sg:pub.10.1038/6854
    21 https://app.dimensions.ai/details/publication/pub.1074642264
    22 https://doi.org/10.1006/excr.1999.4687
    23 https://doi.org/10.1016/0092-8674(94)90056-6
    24 https://doi.org/10.1016/0092-8674(95)90402-6
    25 https://doi.org/10.1016/s0092-8674(00)00027-1
    26 https://doi.org/10.1016/s0092-8674(00)00193-8
    27 https://doi.org/10.1016/s0092-8674(00)81767-5
    28 https://doi.org/10.1016/s0092-8674(00)81999-6
    29 https://doi.org/10.1016/s0896-6273(00)80727-8
    30 https://doi.org/10.1016/s0925-4773(99)00213-0
    31 https://doi.org/10.1016/s0955-0674(96)80067-6
    32 https://doi.org/10.1016/s0960-9822(99)80065-7
    33 https://doi.org/10.1016/s0960-9822(99)80164-x
    34 https://doi.org/10.1016/s1074-7613(00)80567-1
    35 https://doi.org/10.1016/s1074-7613(00)80640-8
    36 https://doi.org/10.1016/s1097-2765(05)00014-6
    37 https://doi.org/10.1073/pnas.94.23.12655
    38 https://doi.org/10.1073/pnas.95.12.6881
    39 https://doi.org/10.1073/pnas.97.10.5243
    40 https://doi.org/10.1084/jem.186.6.941
    41 https://doi.org/10.1084/jem.193.3.317
    42 https://doi.org/10.1093/emboj/17.17.5037
    43 https://doi.org/10.1093/emboj/18.1.270
    44 https://doi.org/10.1093/emboj/18.7.1845
    45 https://doi.org/10.1093/emboj/19.24.6742
    46 https://doi.org/10.1101/gad.12.21.3369
    47 https://doi.org/10.1126/science.270.5240.1326
    48 https://doi.org/10.1126/science.271.5253.1272
    49 https://doi.org/10.1126/science.281.5383.1668
    50 https://doi.org/10.1126/science.281.5383.1671
    51 https://doi.org/10.1126/science.282.5395.1911
    52 https://doi.org/10.1126/science.282.5396.2092
    53 https://doi.org/10.1126/science.286.5443.1358
    54 https://doi.org/10.1126/science.286.5443.1362
    55 https://doi.org/10.1126/science.286.5443.1365
    56 https://doi.org/10.1126/science.286.5443.1374
    57 https://doi.org/10.1126/science.288.5467.870
    58 https://doi.org/10.1126/science.7992057
    59 https://doi.org/10.1126/stke.2000.40.re1
    60 https://doi.org/10.1128/mcb.19.1.321
    61 https://doi.org/10.1128/mcb.19.1.751
    62 https://doi.org/10.1128/mcb.20.12.4265-4274.2000
    63 schema:datePublished 2001-03
    64 schema:datePublishedReg 2001-03-01
    65 schema:description Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree false
    69 schema:isPartOf N13b88af506cc426e84b2a614ed388487
    70 Nd0726f6fb1ae46f1985cf3a7c785c7d1
    71 sg:journal.1018957
    72 schema:name Mammalian MAP kinase signalling cascades
    73 schema:pagination 37
    74 schema:productId N21d294798925477fbd3b2e728dd805ba
    75 N452f64fc1206497bb195decc1ebff1e4
    76 N668c51f0dadf4564a1a8f9a8889c6389
    77 N83168d44e9d742bca917736c915c07b1
    78 N842da2af0c9c4dfcbe7a0d4461bfa89b
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029421135
    80 https://doi.org/10.1038/35065000
    81 schema:sdDatePublished 2019-04-11T12:21
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher N7e7c40c202c0470c8c1e1fca73039339
    84 schema:url https://www.nature.com/articles/35065000
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N092b7a9191964c45a2210d9c498712ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Mitogen-Activated Protein Kinase Kinases
    90 rdf:type schema:DefinedTerm
    91 N13b88af506cc426e84b2a614ed388487 schema:issueNumber 6824
    92 rdf:type schema:PublicationIssue
    93 N21d294798925477fbd3b2e728dd805ba schema:name doi
    94 schema:value 10.1038/35065000
    95 rdf:type schema:PropertyValue
    96 N41f9cd9045f141e19fa75101857e41bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Substrate Specificity
    98 rdf:type schema:DefinedTerm
    99 N452f64fc1206497bb195decc1ebff1e4 schema:name dimensions_id
    100 schema:value pub.1029421135
    101 rdf:type schema:PropertyValue
    102 N45680a883c8d429eaa222f82d41edfb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Enzyme Activation
    104 rdf:type schema:DefinedTerm
    105 N5a7dab8f0f8342eab1e4905cd53647dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Mammals
    107 rdf:type schema:DefinedTerm
    108 N668c51f0dadf4564a1a8f9a8889c6389 schema:name nlm_unique_id
    109 schema:value 0410462
    110 rdf:type schema:PropertyValue
    111 N7b5aec050eef4a4487c5fba9ffb077c3 rdf:first sg:person.01175630061.53
    112 rdf:rest Na3ea722ccdf54c3bac25c4df9c85a4f1
    113 N7e7c40c202c0470c8c1e1fca73039339 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N83168d44e9d742bca917736c915c07b1 schema:name pubmed_id
    116 schema:value 11242034
    117 rdf:type schema:PropertyValue
    118 N842da2af0c9c4dfcbe7a0d4461bfa89b schema:name readcube_id
    119 schema:value 8c2837ccbd42232d6fefebe73e7d79db28d8745c19f832ba50c59cc8e4a38247
    120 rdf:type schema:PropertyValue
    121 N892060fd01cc4051b5535c30103c9d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name MAP Kinase Signaling System
    123 rdf:type schema:DefinedTerm
    124 N91a2ae92657045c6828cd912a030a2d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Mitogen-Activated Protein Kinases
    126 rdf:type schema:DefinedTerm
    127 N9933a1095de14845a320b130b76b389c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Animals
    129 rdf:type schema:DefinedTerm
    130 Na3ea722ccdf54c3bac25c4df9c85a4f1 rdf:first sg:person.0706540600.87
    131 rdf:rest rdf:nil
    132 Nd0726f6fb1ae46f1985cf3a7c785c7d1 schema:volumeNumber 410
    133 rdf:type schema:PublicationVolume
    134 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Biological Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Biochemistry and Cell Biology
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1018957 schema:issn 0090-0028
    141 1476-4687
    142 schema:name Nature
    143 rdf:type schema:Periodical
    144 sg:person.01175630061.53 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    145 schema:familyName Chang
    146 schema:givenName Lufen
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175630061.53
    148 rdf:type schema:Person
    149 sg:person.0706540600.87 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
    150 schema:familyName Karin
    151 schema:givenName Michael
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706540600.87
    153 rdf:type schema:Person
    154 sg:pub.10.1038/10061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047914855
    155 https://doi.org/10.1038/10061
    156 rdf:type schema:CreativeWork
    157 sg:pub.10.1038/35000065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050094560
    158 https://doi.org/10.1038/35000065
    159 rdf:type schema:CreativeWork
    160 sg:pub.10.1038/35002111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010185178
    161 https://doi.org/10.1038/35002111
    162 rdf:type schema:CreativeWork
    163 sg:pub.10.1038/35011091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018609726
    164 https://doi.org/10.1038/35011091
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1038/365179a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009910352
    167 https://doi.org/10.1038/365179a0
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/373620a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024659816
    170 https://doi.org/10.1038/373620a0
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/385544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031372205
    173 https://doi.org/10.1038/385544a0
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/386296a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050357476
    176 https://doi.org/10.1038/386296a0
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1038/39899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035322653
    179 https://doi.org/10.1038/39899
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1038/6854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009130897
    182 https://doi.org/10.1038/6854
    183 rdf:type schema:CreativeWork
    184 https://app.dimensions.ai/details/publication/pub.1074642264 schema:CreativeWork
    185 https://doi.org/10.1006/excr.1999.4687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029427955
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/0092-8674(94)90056-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052300306
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/0092-8674(95)90402-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012072151
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/s0092-8674(00)00027-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000558502
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/s0092-8674(00)00193-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053689810
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/s0092-8674(00)81767-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002656663
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/s0092-8674(00)81999-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044894434
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/s0896-6273(00)80727-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019812256
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/s0925-4773(99)00213-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022839551
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/s0955-0674(96)80067-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036309979
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/s0960-9822(99)80065-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014242834
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/s0960-9822(99)80164-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048205266
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/s1074-7613(00)80567-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023590652
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/s1074-7613(00)80640-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023543830
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/s1097-2765(05)00014-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018779619
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1073/pnas.94.23.12655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042256547
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1073/pnas.95.12.6881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042140977
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1073/pnas.97.10.5243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027471800
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1084/jem.186.6.941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024792548
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1084/jem.193.3.317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018306000
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1093/emboj/17.17.5037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002109213
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1093/emboj/18.1.270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026295363
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1093/emboj/18.7.1845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047311018
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1093/emboj/19.24.6742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015235035
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1101/gad.12.21.3369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015090406
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1126/science.270.5240.1326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551677
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1126/science.271.5253.1272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552348
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1126/science.281.5383.1668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562415
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1126/science.281.5383.1671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025126757
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1126/science.282.5395.1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563451
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1126/science.282.5396.2092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563528
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1126/science.286.5443.1358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567287
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1126/science.286.5443.1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567288
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1126/science.286.5443.1365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567289
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1126/science.286.5443.1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052331127
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1126/science.288.5467.870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062569393
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1126/science.7992057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650899
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1126/stke.2000.40.re1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062689924
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1128/mcb.19.1.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002839988
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1128/mcb.19.1.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002493528
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1128/mcb.20.12.4265-4274.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026500080
    266 rdf:type schema:CreativeWork
    267 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
    268 schema:name Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA
    269 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...