Chromosomal stability and the DNA double-stranded break connection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

D C van Gent, J H Hoeijmakers, R Kanaar

ABSTRACT

Genome stability is of primary importance for the survival and proper functioning of all organisms. Double-stranded breaks in DNA are important threats to genome integrity because they can result in chromosomal aberrations that can affect, simultaneously, many genes, and lead to cell malfunctioning and cell death. These detrimental consequences are counteracted by two mechanistically distinct pathways of double-stranded break repair: homologous recombination and non-homologous end-joining. Recently, unexpected links between these double-stranded break-repair systems, and several human genome instability and cancer predisposition syndromes, have emerged. Now, interactions between both double-stranded break-repair pathways and other cellular processes, such as cell-cycle regulation and replication, are being unveiled. More... »

PAGES

196-206

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  • Journal

    TITLE

    Nature Reviews Genetics

    ISSUE

    3

    VOLUME

    2

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35056049

    DOI

    http://dx.doi.org/10.1038/35056049

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028620907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11256071


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35056049'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35056049'

    Turtle is a human-readable linked data format.

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