Genome sequence of enterohaemorrhagic Escherichia coli O157:H7 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-01

AUTHORS

Nicole T. Perna, Guy Plunkett, Valerie Burland, Bob Mau, Jeremy D. Glasner, Debra J. Rose, George F. Mayhew, Peter S. Evans, Jason Gregor, Heather A. Kirkpatrick, György Pósfai, Jeremiah Hackett, Sara Klink, Adam Boutin, Ying Shao, Leslie Miller, Erik J. Grotbeck, N. Wayne Davis, Alex Lim, Eileen T. Dimalanta, Konstantinos D. Potamousis, Jennifer Apodaca, Thomas S. Anantharaman, Jieyi Lin, Galex Yen, David C. Schwartz, Rodney A. Welch, Frederick R. Blattner

ABSTRACT

The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been implicated in many outbreaks of haemorrhagic colitis, some of which included fatalities caused by haemolytic uraemic syndrome. Close to 75,000 cases of O157:H7 infection are now estimated to occur annually in the United States. The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157:H7 (ref. 4). Here we have sequenced the genome of E. coli O157:H7 to identify candidate genes responsible for pathogenesis, to develop better methods of strain detection and to advance our understanding of the evolution of E. coli, through comparison with the genome of the non-pathogenic laboratory strain E. coli K-12 (ref. 5). We find that lateral gene transfer is far more extensive than previously anticipated. In fact, 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7. These include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions--all of which could be targets for surveillance. More... »

PAGES

529

Journal

TITLE

Nature

ISSUE

6819

VOLUME

409

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35054089

    DOI

    http://dx.doi.org/10.1038/35054089

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020385479

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11206551


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