Untangling the ErbB signalling network View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-02

AUTHORS

Y Yarden, M X Sliwkowski

ABSTRACT

When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin), a recombinant antibody designed to block the receptor ErbB2. Likewise, small-molecule enzyme inhibitors and monoclonal antibodies to ErbB1 are in advanced phases of clinical testing. What can this pathway teach us about translating basic science into clinical use? More... »

PAGES

127-137

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Molecular Cell Biology

    ISSUE

    2

    VOLUME

    2

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35052073

    DOI

    http://dx.doi.org/10.1038/35052073

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053565592

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11252954


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