A role for ghrelin in the central regulation of feeding View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-01

AUTHORS

Masamitsu Nakazato, Noboru Murakami, Yukari Date, Masayasu Kojima, Hisayuki Matsuo, Kenji Kangawa, Shigeru Matsukura

ABSTRACT

Ghrelin is an acylated peptide that stimulates the release of growth hormone from the pituitary. Ghrelin-producing neurons are located in the hypothalamus, whereas ghrelin receptors are expressed in various regions of the brain, which is indicative of central-and as yet undefined-physiological functions. Here we show that ghrelin is involved in the hypothalamic regulation of energy homeostasis. Intracerebroventricular injections of ghrelin strongly stimulated feeding in rats and increased body weight gain. Ghrelin also increased feeding in rats that are genetically deficient in growth hormone. Anti-ghrelin immunoglobulin G robustly suppressed feeding. After intracerebroventricular ghrelin administration, Fos protein, a marker of neuronal activation, was found in regions of primary importance in the regulation of feeding, including neuropeptide Y6 (NPY) neurons and agouti-related protein (AGRP) neurons. Antibodies and antagonists of NPY and AGRP abolished ghrelin-induced feeding. Ghrelin augmented NPY gene expression and blocked leptin-induced feeding reduction, implying that there is a competitive interaction between ghrelin and leptin in feeding regulation. We conclude that ghrelin is a physiological mediator of feeding, and probably has a function in growth regulation by stimulating feeding and release of growth hormone. More... »

PAGES

194

Journal

TITLE

Nature

ISSUE

6817

VOLUME

409

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35051587

DOI

http://dx.doi.org/10.1038/35051587

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004504803

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11196643


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