The DNA damage response: putting checkpoints in perspective View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

Bin-Bing S. Zhou, Stephen J. Elledge

ABSTRACT

The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks. More... »

PAGES

433

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35044005

    DOI

    http://dx.doi.org/10.1038/35044005

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053296306

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11100718


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