Genetic pathways that regulate ageing in model organisms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

L Guarente, C Kenyon

ABSTRACT

Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms. More... »

PAGES

255-262

References to SciGraph publications

  • 1999-12. Regulation of lifespan by sensory perception in Caenorhabditis elegans in NATURE
  • 1999-05. Signals from the reproductive system regulate the lifespan of C. elegans in NATURE
  • 1993-02. The genetics of aging in the yeastSaccharomyces cerevisiae in GENETICA
  • 1987-06. Age related reactivation of an X-linked gene in NATURE
  • 1999-11. The p66shc adaptor protein controls oxidative stress response and life span in mammals in NATURE
  • 1998-08. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes in NATURE
  • 1996-11. Dwarf mice and the ageing process in NATURE
  • 1999-05. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants in NATURE
  • 1998-06. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons in NATURE GENETICS
  • 1959-06. Life Span of Individual Yeast Cells in NATURE
  • 1997-10. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans in NATURE
  • 1996-08. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans in NATURE
  • 1998-02. Mutations in PROP1 cause familial combined pituitary hormone deficiency in NATURE GENETICS
  • 2000-02. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase in NATURE
  • 1993-12. A C. elegans mutant that lives twice as long as wild type in NATURE
  • 1999-04. Direct control of the Forkhead transcription factor AFX by protein kinase B in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    6809

    VOLUME

    408

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35041700

    DOI

    http://dx.doi.org/10.1038/35041700

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003389377

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11089983


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