Genetic pathways that regulate ageing in model organisms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

L Guarente, C Kenyon

ABSTRACT

Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms. More... »

PAGES

255-262

References to SciGraph publications

  • 1999-12. Regulation of lifespan by sensory perception in Caenorhabditis elegans in NATURE
  • 1999-05. Signals from the reproductive system regulate the lifespan of C. elegans in NATURE
  • 1993-02. The genetics of aging in the yeastSaccharomyces cerevisiae in GENETICA
  • 1987-06. Age related reactivation of an X-linked gene in NATURE
  • 1999-11. The p66shc adaptor protein controls oxidative stress response and life span in mammals in NATURE
  • 1998-08. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes in NATURE
  • 1996-11. Dwarf mice and the ageing process in NATURE
  • 1999-05. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants in NATURE
  • 1998-06. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons in NATURE GENETICS
  • 1959-06. Life Span of Individual Yeast Cells in NATURE
  • 1997-10. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans in NATURE
  • 1996-08. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans in NATURE
  • 1998-02. Mutations in PROP1 cause familial combined pituitary hormone deficiency in NATURE GENETICS
  • 2000-02. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase in NATURE
  • 1993-12. A C. elegans mutant that lives twice as long as wild type in NATURE
  • 1999-04. Direct control of the Forkhead transcription factor AFX by protein kinase B in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    6809

    VOLUME

    408

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35041700

    DOI

    http://dx.doi.org/10.1038/35041700

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003389377

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11089983


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caenorhabditis elegans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila melanogaster", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Energy Intake", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hormones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Longevity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons, Afferent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Silent Information Regulator Proteins, Saccharomyces cerevisiae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sirtuin 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sirtuins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Yeasts", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guarente", 
            "givenName": "L", 
            "id": "sg:person.01325652577.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325652577.08"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Kenyon", 
            "givenName": "C", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1091/mbc.10.10.3125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000410161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.16.9100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000901972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.2000.2971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001155363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81038-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001897301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0531-5565(00)00079-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001976636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90681-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002387122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01435986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003278491", 
              "https://doi.org/10.1007/bf01435986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01435986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003278491", 
              "https://doi.org/10.1007/bf01435986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.22.13091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003296828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0031-9384(99)00098-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004108639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.4.3184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004662216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvg.1020120505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007732858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvg.1020120505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007732858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.11.1438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008321215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2443.1999.00288.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008321622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009108746", 
              "https://doi.org/10.1038/19328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009108746", 
              "https://doi.org/10.1038/19328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/384033a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009383718", 
              "https://doi.org/10.1038/384033a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.277.5328.942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009449154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.6.2925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010278953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.13.7421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010481623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366461a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011026745", 
              "https://doi.org/10.1038/366461a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0891-5849(00)00186-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011790959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81671-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013643028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.16.7540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016184894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.19.2570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016621585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.23.15982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017639483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90141-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019171834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019839382", 
              "https://doi.org/10.1038/35001622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019839382", 
              "https://doi.org/10.1038/35001622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.19.8905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020169117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5341.1319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020198490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80493-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021548396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90499-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022321661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762380", 
              "https://doi.org/10.1038/40194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762380", 
              "https://doi.org/10.1038/40194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.2.255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024673208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1999.0897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024732867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80303-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5489.147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029272663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0298-147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030737601", 
              "https://doi.org/10.1038/ng0298-147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032110116", 
              "https://doi.org/10.1038/20208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032110116", 
              "https://doi.org/10.1038/20208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/1831751a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032400036", 
              "https://doi.org/10.1038/1831751a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80595-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032865792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032931798", 
              "https://doi.org/10.1038/20694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/20694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032931798", 
              "https://doi.org/10.1038/20694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.110148297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034076977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.9.23.2888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037815698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-1878(200001)22:1<48::aid-bies9>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038998904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80072-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039026112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/45544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039516104", 
              "https://doi.org/10.1038/45544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/45544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039516104", 
              "https://doi.org/10.1038/45544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81751-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040992208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.78.11.7124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041646827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mgme.1999.2890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042024049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0047-6374(77)90043-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042243326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0047-6374(77)90043-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042243326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.16.2488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042644391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(99)80143-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043531613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043689977", 
              "https://doi.org/10.1038/534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043689977", 
              "https://doi.org/10.1038/534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.11.2.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043891034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/382536a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044090038", 
              "https://doi.org/10.1038/382536a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5390.943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044565323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00015-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045230103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.14.12.1512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045481688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.12.6658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046753843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.24.17179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047232902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.1.216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048492079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.13.7394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048641263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.7.4.592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049475831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050418051", 
              "https://doi.org/10.1038/29331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050418051", 
              "https://doi.org/10.1038/29331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.1990.tb00568.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050632263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0531-5565(98)00032-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052107422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.20.11399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052199137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/46311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052501543", 
              "https://doi.org/10.1038/46311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/46311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052501543", 
              "https://doi.org/10.1038/46311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80472-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052558592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.13.7427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052778892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/327725a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056438795", 
              "https://doi.org/10.1038/327725a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/physzool.58.4.30156013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058930558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/geronj/43.4.b102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059628276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.273.5271.59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062553533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.277.5330.1313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062557837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5449.2521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5484.1567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062570840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5487.2126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062571005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3027892", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062583659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3526554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062619044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.171.1.37-42.1989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062717308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074365934", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.13.11.1385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074499627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074639622", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074678186", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077376850", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079669275", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/116.4.641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080053825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fasebj.9.13.7557026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082411807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082508555", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082630025", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082816464", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082876125", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082961318", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083227984", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083312263", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-11", 
        "datePublishedReg": "2000-11-01", 
        "description": "Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/35041700", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6809", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "408"
          }
        ], 
        "name": "Genetic pathways that regulate ageing in model organisms", 
        "pagination": "255-262", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "10250af761c1076f94138ba0e0054ea650af0ef0a711bedf6ceeaa50ea9b6a78"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11089983"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/35041700"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003389377"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/35041700", 
          "https://app.dimensions.ai/details/publication/pub.1003389377"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87100_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/35041700"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35041700'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35041700'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35041700'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35041700'


     

    This table displays all metadata directly associated to this object as RDF triples.

    439 TRIPLES      21 PREDICATES      143 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/35041700 schema:about N01d7c234573e45a3b88e300f02e940c0
    2 N02466359140349c1a9016bad8e644bc6
    3 N204cb0992f6a4e83b68e715f4dd243b9
    4 N31b5f8eff1bb493ba17551f16a2dbf75
    5 N4ae0c67322a94108aef74f6f14dd5739
    6 N4ea845d6f37440958c63f6f1daa89349
    7 N5dcfb8aa258f44b88fffd0824f9e30ca
    8 N6f8dc66331d8424395f7f6fcedda184a
    9 N7d6b8e8b84be4059b4e81035a3c4ca22
    10 N9036d9271e1d429bb5008b13db8e16e2
    11 N91ae8253846b440f8b61e57cd45bac6a
    12 Nad89f7b612dd417b85aef7f26cdeff41
    13 Nba8d4b73393342198f0cd1fcc01eaea3
    14 Nbca697413c024696aa6cbd5f00f02639
    15 Nbf2b79fe122c4816989c973da32cdbb6
    16 Nca1d489a9aff4dc0850ef5a87b6a11e7
    17 Ndc5d6c32198d4db18c34d2732c9ad73b
    18 Ne1ad50ea132b4b638238640f892a0636
    19 Ned05fe2ba3ee43daa788a6f54eefac43
    20 anzsrc-for:06
    21 anzsrc-for:0604
    22 schema:author Nc58b9656cefa4e15acdf9833d4124f30
    23 schema:citation sg:pub.10.1007/bf01435986
    24 sg:pub.10.1038/1831751a0
    25 sg:pub.10.1038/19328
    26 sg:pub.10.1038/20208
    27 sg:pub.10.1038/20694
    28 sg:pub.10.1038/29331
    29 sg:pub.10.1038/327725a0
    30 sg:pub.10.1038/35001622
    31 sg:pub.10.1038/366461a0
    32 sg:pub.10.1038/382536a0
    33 sg:pub.10.1038/384033a0
    34 sg:pub.10.1038/40194
    35 sg:pub.10.1038/45544
    36 sg:pub.10.1038/46311
    37 sg:pub.10.1038/534
    38 sg:pub.10.1038/ng0298-147
    39 https://app.dimensions.ai/details/publication/pub.1074365934
    40 https://app.dimensions.ai/details/publication/pub.1074639622
    41 https://app.dimensions.ai/details/publication/pub.1074678186
    42 https://app.dimensions.ai/details/publication/pub.1077376850
    43 https://app.dimensions.ai/details/publication/pub.1079669275
    44 https://app.dimensions.ai/details/publication/pub.1082508555
    45 https://app.dimensions.ai/details/publication/pub.1082630025
    46 https://app.dimensions.ai/details/publication/pub.1082816464
    47 https://app.dimensions.ai/details/publication/pub.1082876125
    48 https://app.dimensions.ai/details/publication/pub.1082961318
    49 https://app.dimensions.ai/details/publication/pub.1083227984
    50 https://app.dimensions.ai/details/publication/pub.1083312263
    51 https://doi.org/10.1002/(sici)1521-1878(200001)22:1<48::aid-bies9>3.0.co;2-f
    52 https://doi.org/10.1002/dvg.1020120505
    53 https://doi.org/10.1006/bbrc.1999.0897
    54 https://doi.org/10.1006/bbrc.2000.2971
    55 https://doi.org/10.1006/mgme.1999.2890
    56 https://doi.org/10.1016/0047-6374(77)90043-4
    57 https://doi.org/10.1016/0092-8674(89)90681-8
    58 https://doi.org/10.1016/0092-8674(90)90141-z
    59 https://doi.org/10.1016/0092-8674(95)90499-9
    60 https://doi.org/10.1016/s0031-9384(99)00098-0
    61 https://doi.org/10.1016/s0092-8674(00)80072-0
    62 https://doi.org/10.1016/s0092-8674(00)80493-6
    63 https://doi.org/10.1016/s0092-8674(00)80595-4
    64 https://doi.org/10.1016/s0092-8674(00)81038-7
    65 https://doi.org/10.1016/s0092-8674(00)81671-2
    66 https://doi.org/10.1016/s0092-8674(00)81751-1
    67 https://doi.org/10.1016/s0531-5565(00)00079-6
    68 https://doi.org/10.1016/s0531-5565(98)00032-1
    69 https://doi.org/10.1016/s0891-5849(00)00186-6
    70 https://doi.org/10.1016/s0960-9822(02)00015-5
    71 https://doi.org/10.1016/s0960-9822(99)80143-2
    72 https://doi.org/10.1016/s1097-2765(00)80303-2
    73 https://doi.org/10.1016/s1097-2765(00)80472-4
    74 https://doi.org/10.1046/j.1365-2443.1999.00288.x
    75 https://doi.org/10.1073/pnas.110148297
    76 https://doi.org/10.1073/pnas.78.11.7124
    77 https://doi.org/10.1073/pnas.90.19.8905
    78 https://doi.org/10.1073/pnas.92.16.7540
    79 https://doi.org/10.1073/pnas.95.22.13091
    80 https://doi.org/10.1073/pnas.96.13.7394
    81 https://doi.org/10.1073/pnas.96.13.7421
    82 https://doi.org/10.1073/pnas.96.13.7427
    83 https://doi.org/10.1073/pnas.96.16.9100
    84 https://doi.org/10.1073/pnas.96.20.11399
    85 https://doi.org/10.1073/pnas.96.6.2925
    86 https://doi.org/10.1073/pnas.97.12.6658
    87 https://doi.org/10.1074/jbc.274.23.15982
    88 https://doi.org/10.1074/jbc.274.24.17179
    89 https://doi.org/10.1086/physzool.58.4.30156013
    90 https://doi.org/10.1091/mbc.10.10.3125
    91 https://doi.org/10.1093/geronj/43.4.b102
    92 https://doi.org/10.1093/jn/116.4.641
    93 https://doi.org/10.1096/fasebj.13.11.1385
    94 https://doi.org/10.1096/fasebj.9.13.7557026
    95 https://doi.org/10.1101/gad.11.2.241
    96 https://doi.org/10.1101/gad.11.2.255
    97 https://doi.org/10.1101/gad.12.16.2488
    98 https://doi.org/10.1101/gad.13.11.1438
    99 https://doi.org/10.1101/gad.13.19.2570
    100 https://doi.org/10.1101/gad.14.12.1512
    101 https://doi.org/10.1101/gad.7.4.592
    102 https://doi.org/10.1101/gad.9.23.2888
    103 https://doi.org/10.1111/j.1365-2958.1990.tb00568.x
    104 https://doi.org/10.1126/science.273.5271.59
    105 https://doi.org/10.1126/science.277.5328.942
    106 https://doi.org/10.1126/science.277.5330.1313
    107 https://doi.org/10.1126/science.278.5341.1319
    108 https://doi.org/10.1126/science.282.5390.943
    109 https://doi.org/10.1126/science.286.5449.2521
    110 https://doi.org/10.1126/science.289.5484.1567
    111 https://doi.org/10.1126/science.289.5487.2126
    112 https://doi.org/10.1126/science.290.5489.147
    113 https://doi.org/10.1126/science.3027892
    114 https://doi.org/10.1126/science.3526554
    115 https://doi.org/10.1128/jb.171.1.37-42.1989
    116 https://doi.org/10.1128/mcb.19.1.216
    117 https://doi.org/10.1128/mcb.19.4.3184
    118 schema:datePublished 2000-11
    119 schema:datePublishedReg 2000-11-01
    120 schema:description Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms.
    121 schema:genre research_article
    122 schema:inLanguage en
    123 schema:isAccessibleForFree false
    124 schema:isPartOf N4d1bb0110407465a8cd10ecd39a857f2
    125 Nb0a69a35d21d4befa4c3a4f4b41f03e1
    126 sg:journal.1018957
    127 schema:name Genetic pathways that regulate ageing in model organisms
    128 schema:pagination 255-262
    129 schema:productId N4e94046e6a054e4592c046b5c722d296
    130 N76ed62779026403b9ca0c24e00cd4ec9
    131 Nbc35ecc5e84f4b3ea0cfa73071c004c1
    132 Nc94cf3b6bb7844a9a17a4c85cf7eb90f
    133 Ne73c56f03fbd44b6b819cf8b1c912719
    134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003389377
    135 https://doi.org/10.1038/35041700
    136 schema:sdDatePublished 2019-04-11T12:24
    137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    138 schema:sdPublisher N142a62fd59944250bec57ef6463796dc
    139 schema:url http://www.nature.com/articles/35041700
    140 sgo:license sg:explorer/license/
    141 sgo:sdDataset articles
    142 rdf:type schema:ScholarlyArticle
    143 N01d7c234573e45a3b88e300f02e940c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Gene Silencing
    145 rdf:type schema:DefinedTerm
    146 N02466359140349c1a9016bad8e644bc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Drosophila Proteins
    148 rdf:type schema:DefinedTerm
    149 N142a62fd59944250bec57ef6463796dc schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N15fc13ee6108443d85a54f055dfc3967 schema:familyName Kenyon
    152 schema:givenName C
    153 rdf:type schema:Person
    154 N204cb0992f6a4e83b68e715f4dd243b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Yeasts
    156 rdf:type schema:DefinedTerm
    157 N31b5f8eff1bb493ba17551f16a2dbf75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Animals
    159 rdf:type schema:DefinedTerm
    160 N360dc26c9d684ba19a33f320bd5ce049 rdf:first N15fc13ee6108443d85a54f055dfc3967
    161 rdf:rest rdf:nil
    162 N4ae0c67322a94108aef74f6f14dd5739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Silent Information Regulator Proteins, Saccharomyces cerevisiae
    164 rdf:type schema:DefinedTerm
    165 N4d1bb0110407465a8cd10ecd39a857f2 schema:volumeNumber 408
    166 rdf:type schema:PublicationVolume
    167 N4e94046e6a054e4592c046b5c722d296 schema:name readcube_id
    168 schema:value 10250af761c1076f94138ba0e0054ea650af0ef0a711bedf6ceeaa50ea9b6a78
    169 rdf:type schema:PropertyValue
    170 N4ea845d6f37440958c63f6f1daa89349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Histone Deacetylases
    172 rdf:type schema:DefinedTerm
    173 N5dcfb8aa258f44b88fffd0824f9e30ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Aging
    175 rdf:type schema:DefinedTerm
    176 N6f8dc66331d8424395f7f6fcedda184a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Energy Intake
    178 rdf:type schema:DefinedTerm
    179 N76ed62779026403b9ca0c24e00cd4ec9 schema:name doi
    180 schema:value 10.1038/35041700
    181 rdf:type schema:PropertyValue
    182 N7d6b8e8b84be4059b4e81035a3c4ca22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Signal Transduction
    184 rdf:type schema:DefinedTerm
    185 N9036d9271e1d429bb5008b13db8e16e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Sirtuin 2
    187 rdf:type schema:DefinedTerm
    188 N91ae8253846b440f8b61e57cd45bac6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Reproduction
    190 rdf:type schema:DefinedTerm
    191 Nad89f7b612dd417b85aef7f26cdeff41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Mutation
    193 rdf:type schema:DefinedTerm
    194 Nb0a69a35d21d4befa4c3a4f4b41f03e1 schema:issueNumber 6809
    195 rdf:type schema:PublicationIssue
    196 Nba8d4b73393342198f0cd1fcc01eaea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Trans-Activators
    198 rdf:type schema:DefinedTerm
    199 Nbc35ecc5e84f4b3ea0cfa73071c004c1 schema:name dimensions_id
    200 schema:value pub.1003389377
    201 rdf:type schema:PropertyValue
    202 Nbca697413c024696aa6cbd5f00f02639 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Neurons, Afferent
    204 rdf:type schema:DefinedTerm
    205 Nbf2b79fe122c4816989c973da32cdbb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Drosophila melanogaster
    207 rdf:type schema:DefinedTerm
    208 Nc58b9656cefa4e15acdf9833d4124f30 rdf:first sg:person.01325652577.08
    209 rdf:rest N360dc26c9d684ba19a33f320bd5ce049
    210 Nc94cf3b6bb7844a9a17a4c85cf7eb90f schema:name nlm_unique_id
    211 schema:value 0410462
    212 rdf:type schema:PropertyValue
    213 Nca1d489a9aff4dc0850ef5a87b6a11e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Longevity
    215 rdf:type schema:DefinedTerm
    216 Ndc5d6c32198d4db18c34d2732c9ad73b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Caenorhabditis elegans
    218 rdf:type schema:DefinedTerm
    219 Ne1ad50ea132b4b638238640f892a0636 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Hormones
    221 rdf:type schema:DefinedTerm
    222 Ne73c56f03fbd44b6b819cf8b1c912719 schema:name pubmed_id
    223 schema:value 11089983
    224 rdf:type schema:PropertyValue
    225 Ned05fe2ba3ee43daa788a6f54eefac43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Sirtuins
    227 rdf:type schema:DefinedTerm
    228 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Biological Sciences
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Genetics
    233 rdf:type schema:DefinedTerm
    234 sg:journal.1018957 schema:issn 0090-0028
    235 1476-4687
    236 schema:name Nature
    237 rdf:type schema:Periodical
    238 sg:person.01325652577.08 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    239 schema:familyName Guarente
    240 schema:givenName L
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325652577.08
    242 rdf:type schema:Person
    243 sg:pub.10.1007/bf01435986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003278491
    244 https://doi.org/10.1007/bf01435986
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/1831751a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032400036
    247 https://doi.org/10.1038/1831751a0
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/19328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009108746
    250 https://doi.org/10.1038/19328
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/20208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032110116
    253 https://doi.org/10.1038/20208
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/20694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032931798
    256 https://doi.org/10.1038/20694
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/29331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050418051
    259 https://doi.org/10.1038/29331
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/327725a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056438795
    262 https://doi.org/10.1038/327725a0
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/35001622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019839382
    265 https://doi.org/10.1038/35001622
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/366461a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011026745
    268 https://doi.org/10.1038/366461a0
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/382536a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044090038
    271 https://doi.org/10.1038/382536a0
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/384033a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009383718
    274 https://doi.org/10.1038/384033a0
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/40194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762380
    277 https://doi.org/10.1038/40194
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/45544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039516104
    280 https://doi.org/10.1038/45544
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/46311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052501543
    283 https://doi.org/10.1038/46311
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043689977
    286 https://doi.org/10.1038/534
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ng0298-147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030737601
    289 https://doi.org/10.1038/ng0298-147
    290 rdf:type schema:CreativeWork
    291 https://app.dimensions.ai/details/publication/pub.1074365934 schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1074639622 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1074678186 schema:CreativeWork
    294 https://app.dimensions.ai/details/publication/pub.1077376850 schema:CreativeWork
    295 https://app.dimensions.ai/details/publication/pub.1079669275 schema:CreativeWork
    296 https://app.dimensions.ai/details/publication/pub.1082508555 schema:CreativeWork
    297 https://app.dimensions.ai/details/publication/pub.1082630025 schema:CreativeWork
    298 https://app.dimensions.ai/details/publication/pub.1082816464 schema:CreativeWork
    299 https://app.dimensions.ai/details/publication/pub.1082876125 schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1082961318 schema:CreativeWork
    301 https://app.dimensions.ai/details/publication/pub.1083227984 schema:CreativeWork
    302 https://app.dimensions.ai/details/publication/pub.1083312263 schema:CreativeWork
    303 https://doi.org/10.1002/(sici)1521-1878(200001)22:1<48::aid-bies9>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1038998904
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/dvg.1020120505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007732858
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1006/bbrc.1999.0897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024732867
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1006/bbrc.2000.2971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001155363
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1006/mgme.1999.2890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042024049
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/0047-6374(77)90043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042243326
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/0092-8674(89)90681-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002387122
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/0092-8674(90)90141-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1019171834
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/0092-8674(95)90499-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022321661
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0031-9384(99)00098-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004108639
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s0092-8674(00)80072-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039026112
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0092-8674(00)80493-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021548396
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s0092-8674(00)80595-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032865792
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s0092-8674(00)81038-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001897301
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s0092-8674(00)81671-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013643028
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s0092-8674(00)81751-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040992208
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s0531-5565(00)00079-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001976636
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/s0531-5565(98)00032-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052107422
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/s0891-5849(00)00186-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011790959
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/s0960-9822(02)00015-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045230103
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/s0960-9822(99)80143-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043531613
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/s1097-2765(00)80303-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027705714
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s1097-2765(00)80472-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052558592
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1046/j.1365-2443.1999.00288.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008321622
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1073/pnas.110148297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034076977
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1073/pnas.78.11.7124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041646827
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1073/pnas.90.19.8905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020169117
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1073/pnas.92.16.7540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016184894
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1073/pnas.95.22.13091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003296828
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1073/pnas.96.13.7394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048641263
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1073/pnas.96.13.7421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010481623
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1073/pnas.96.13.7427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052778892
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1073/pnas.96.16.9100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000901972
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1073/pnas.96.20.11399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052199137
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1073/pnas.96.6.2925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010278953
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1073/pnas.97.12.6658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046753843
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1074/jbc.274.23.15982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017639483
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1074/jbc.274.24.17179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047232902
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1086/physzool.58.4.30156013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058930558
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1091/mbc.10.10.3125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000410161
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1093/geronj/43.4.b102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059628276
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/jn/116.4.641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080053825
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1096/fasebj.13.11.1385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074499627
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1096/fasebj.9.13.7557026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082411807
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1101/gad.11.2.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043891034
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1101/gad.11.2.255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024673208
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1101/gad.12.16.2488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042644391
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1101/gad.13.11.1438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008321215
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1101/gad.13.19.2570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016621585
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1101/gad.14.12.1512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045481688
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1101/gad.7.4.592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049475831
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1101/gad.9.23.2888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037815698
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1111/j.1365-2958.1990.tb00568.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050632263
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1126/science.273.5271.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553533
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1126/science.277.5328.942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009449154
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1126/science.277.5330.1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062557837
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1126/science.278.5341.1319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020198490
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1126/science.282.5390.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044565323
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1126/science.286.5449.2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567810
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1126/science.289.5484.1567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570840
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1126/science.289.5487.2126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571005
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1126/science.290.5489.147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029272663
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1126/science.3027892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062583659
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1126/science.3526554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062619044
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1128/jb.171.1.37-42.1989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062717308
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1128/mcb.19.1.216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048492079
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1128/mcb.19.4.3184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004662216
    436 rdf:type schema:CreativeWork
    437 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    438 schema:name Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
    439 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...