Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Naoki Kunishima, Yoshimi Shimada, Yuji Tsuji, Toshihiro Sato, Masaki Yamamoto, Takashi Kumasaka, Shigetada Nakanishi, Hisato Jingami, Kosuke Morikawa

ABSTRACT

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. Here we have determined three different crystal structures of the extracellular ligand-binding region of mGluR1--in a complex with glutamate and in two unliganded forms. They all showed disulphide-linked homodimers, whose 'active' and 'resting' conformations are modulated through the dimeric interface by a packed alpha-helical structure. The bi-lobed protomer architectures flexibly change their domain arrangements to form an 'open' or 'closed' conformation. The structures imply that glutamate binding stabilizes both the 'active' dimer and the 'closed' protomer in dynamic equilibrium. Movements of the four domains in the dimer are likely to affect the separation of the transmembrane and intracellular regions, and thereby activate the receptor. This scheme in the initial receptor activation could be applied generally to G-protein-coupled neurotransmitter receptors that possess extracellular ligand-binding sites. More... »

PAGES

971

Journal

TITLE

Nature

ISSUE

6807

VOLUME

407

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35039564

DOI

http://dx.doi.org/10.1038/35039564

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049108980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11069170


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35039564'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35039564'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35039564'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35039564'


 

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