Ghrelin induces adiposity in rodents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Matthias Tschöp, David L. Smiley, Mark L. Heiman

ABSTRACT

The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along with GH-releasing hormone and somatostatin, GHS receptors have also been identified on hypothalamic neurons and in the brainstem. Apart from potential paracrine effects, ghrelin may thus offer an endocrine link between stomach, hypothalamus and pituitary, suggesting an involvement in regulation of energy balance. Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body weight. Rat serum ghrelin concentrations were increased by fasting and were reduced by re-feeding or oral glucose administration, but not by water ingestion. We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary. More... »

PAGES

908

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35038090

DOI

http://dx.doi.org/10.1038/35038090

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019046140

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11057670


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Circadian Rhythm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Food", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ghrelin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth Hormone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Injections, Intraventricular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, G-Protein-Coupled", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Ghrelin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Weight Gain", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Eli Lilly (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417540.3", 
          "name": [
            "Endocrine Research and BioResearch Technologies & Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Drop Code 0545, Indianapolis, Indiana 46285, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsch\u00f6p", 
        "givenName": "Matthias", 
        "id": "sg:person.013151674377.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151674377.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417540.3", 
          "name": [
            "Endocrine Research and BioResearch Technologies & Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Drop Code 0545, Indianapolis, Indiana 46285, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smiley", 
        "givenName": "David L.", 
        "id": "sg:person.0706144321.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706144321.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417540.3", 
          "name": [
            "Endocrine Research and BioResearch Technologies & Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Drop Code 0545, Indianapolis, Indiana 46285, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heiman", 
        "givenName": "Mark L.", 
        "id": "sg:person.01164056647.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164056647.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/381415a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002805086", 
          "https://doi.org/10.1038/381415a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000054462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010433221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-328x(97)00071-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010560713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1190051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014009589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m002784200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014180586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000421672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014715010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9384(85)90165-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016978838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9384(85)90165-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016978838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2826.2000.00398.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018646236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0955-2863(91)90016-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030333291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9384(93)90264-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031870674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9384(93)90264-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031870674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000054463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034379577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198912283212605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035706202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000054491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036531128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/45230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039795518", 
          "https://doi.org/10.1038/45230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/45230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039795518", 
          "https://doi.org/10.1038/45230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(87)53067-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044117603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(00)00882-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048420564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/joe.0.1500129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050430570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-0115(00)00157-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051066290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5277.974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062553900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-116-1-410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064258545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.137.11.8895390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064280608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.83.11.5265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064321462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend.11.4.9908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064331446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/128.2.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083204549"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-10", 
    "datePublishedReg": "2000-10-01", 
    "description": "The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along with GH-releasing hormone and somatostatin, GHS receptors have also been identified on hypothalamic neurons and in the brainstem. Apart from potential paracrine effects, ghrelin may thus offer an endocrine link between stomach, hypothalamus and pituitary, suggesting an involvement in regulation of energy balance. Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body weight. Rat serum ghrelin concentrations were increased by fasting and were reduced by re-feeding or oral glucose administration, but not by water ingestion. We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/35038090", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6806", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "407"
      }
    ], 
    "name": "Ghrelin induces adiposity in rodents", 
    "pagination": "908", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5abf9efbe894f4471adbc4a18300423cfc6925568c9c85cb51bbcdd8afac0622"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11057670"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/35038090"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019046140"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/35038090", 
      "https://app.dimensions.ai/details/publication/pub.1019046140"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/35038090"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35038090'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35038090'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35038090'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35038090'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      73 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/35038090 schema:about N0040565511ce4169967e5299e2645c23
2 N1967ba22f2d34eefb4a8fed186a7fcb3
3 N1cf78594ed6e466e84ee1c11e1c1504f
4 N2ae32c7038db48c39be9ab1062b197a1
5 N36ea8bd0b41140acadbfa3ff1d468583
6 N3e0e51a93b714b61b24cabd407474033
7 N476f32f13c6b4c06af5c3c63d4aa11c8
8 N4d0948d141df4c8eb0a95db68a728d2a
9 N725d263b1a844c448fae47dba8b08463
10 N815d3bec8b43413dbd3fecf44230bc28
11 N9da5970068ea44beb138d7f39ddd9717
12 Naee7f1c971ad4b5888b8b2140e7f3caf
13 Nb2fe92fd5ff34cbe8efb86687453f2b0
14 Ncc3463713055457f96f5d8ee106e27e0
15 Nceb38ac4c7044e309b5e0bb03571b852
16 Nd3ab48fdf8084e74ba3847f04ce50ecd
17 Nd70d0eb51e844a47b22c43bd1e77ca6c
18 Ne26f6bbbf0934a1d836cbc09b7fc00b8
19 Ne821488c7fb949fc8ffff9efb440b2d7
20 Nea6d81136a4346aab79cdacbe8ecb795
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N0412329b2f4445f0b1bda2f3fb9524e7
24 schema:citation sg:pub.10.1038/381415a0
25 sg:pub.10.1038/45230
26 https://doi.org/10.1016/0031-9384(85)90165-9
27 https://doi.org/10.1016/0031-9384(93)90264-g
28 https://doi.org/10.1016/0076-6879(87)53067-1
29 https://doi.org/10.1016/0955-2863(91)90016-x
30 https://doi.org/10.1016/s0167-0115(00)00157-9
31 https://doi.org/10.1016/s0169-328x(97)00071-5
32 https://doi.org/10.1016/s0304-3940(00)00882-x
33 https://doi.org/10.1046/j.1365-2826.2000.00398.x
34 https://doi.org/10.1056/nejm198912283212605
35 https://doi.org/10.1074/jbc.m002784200
36 https://doi.org/10.1093/jn/128.2.246
37 https://doi.org/10.1126/science.273.5277.974
38 https://doi.org/10.1159/000054462
39 https://doi.org/10.1159/000054463
40 https://doi.org/10.1159/000054491
41 https://doi.org/10.1159/000421672
42 https://doi.org/10.1210/endo-116-1-410
43 https://doi.org/10.1210/endo.137.11.8895390
44 https://doi.org/10.1210/jcem.83.11.5265
45 https://doi.org/10.1210/mend.11.4.9908
46 https://doi.org/10.1677/joe.0.1190051
47 https://doi.org/10.1677/joe.0.1500129
48 schema:datePublished 2000-10
49 schema:datePublishedReg 2000-10-01
50 schema:description The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor, yielded the surprising result that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion along with GH-releasing hormone and somatostatin, GHS receptors have also been identified on hypothalamic neurons and in the brainstem. Apart from potential paracrine effects, ghrelin may thus offer an endocrine link between stomach, hypothalamus and pituitary, suggesting an involvement in regulation of energy balance. Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body weight. Rat serum ghrelin concentrations were increased by fasting and were reduced by re-feeding or oral glucose administration, but not by water ingestion. We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N41399b6f405f49c3b4d249972b1d5df3
55 N794cf2d8914b4623acbe67f0a8735ee3
56 sg:journal.1018957
57 schema:name Ghrelin induces adiposity in rodents
58 schema:pagination 908
59 schema:productId N1caee9dfd67c4924b69fde51c638763f
60 N35ef33cb49b047128bc4239d8144ed35
61 N5c7d57e776754d8c828de837a34ddeae
62 N6ad1b67bedfb4058896e2af23a8085d0
63 Neb59dd06d6834aad9fff0fd88ed0393f
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019046140
65 https://doi.org/10.1038/35038090
66 schema:sdDatePublished 2019-04-11T12:23
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N03dd8eaa29c34f1ab34ae0a26c3e2e8c
69 schema:url https://www.nature.com/articles/35038090
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N0040565511ce4169967e5299e2645c23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Hypothalamus
75 rdf:type schema:DefinedTerm
76 N03dd8eaa29c34f1ab34ae0a26c3e2e8c schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N0412329b2f4445f0b1bda2f3fb9524e7 rdf:first sg:person.013151674377.03
79 rdf:rest N9a01d24ea12a4bd9a67b5604dbdecdb2
80 N1967ba22f2d34eefb4a8fed186a7fcb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Energy Metabolism
82 rdf:type schema:DefinedTerm
83 N1caee9dfd67c4924b69fde51c638763f schema:name dimensions_id
84 schema:value pub.1019046140
85 rdf:type schema:PropertyValue
86 N1cf78594ed6e466e84ee1c11e1c1504f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Adipose Tissue
88 rdf:type schema:DefinedTerm
89 N2ae32c7038db48c39be9ab1062b197a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Weight Gain
91 rdf:type schema:DefinedTerm
92 N35ef33cb49b047128bc4239d8144ed35 schema:name doi
93 schema:value 10.1038/35038090
94 rdf:type schema:PropertyValue
95 N36ea8bd0b41140acadbfa3ff1d468583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Fasting
97 rdf:type schema:DefinedTerm
98 N3e0e51a93b714b61b24cabd407474033 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mice
100 rdf:type schema:DefinedTerm
101 N41399b6f405f49c3b4d249972b1d5df3 schema:volumeNumber 407
102 rdf:type schema:PublicationVolume
103 N476f32f13c6b4c06af5c3c63d4aa11c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Receptors, Ghrelin
105 rdf:type schema:DefinedTerm
106 N4d0948d141df4c8eb0a95db68a728d2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Growth Hormone
108 rdf:type schema:DefinedTerm
109 N54bbf917548d4b6e909be8aa8ed30d66 rdf:first sg:person.01164056647.53
110 rdf:rest rdf:nil
111 N5c7d57e776754d8c828de837a34ddeae schema:name readcube_id
112 schema:value 5abf9efbe894f4471adbc4a18300423cfc6925568c9c85cb51bbcdd8afac0622
113 rdf:type schema:PropertyValue
114 N6ad1b67bedfb4058896e2af23a8085d0 schema:name nlm_unique_id
115 schema:value 0410462
116 rdf:type schema:PropertyValue
117 N725d263b1a844c448fae47dba8b08463 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Ghrelin
119 rdf:type schema:DefinedTerm
120 N794cf2d8914b4623acbe67f0a8735ee3 schema:issueNumber 6806
121 rdf:type schema:PublicationIssue
122 N815d3bec8b43413dbd3fecf44230bc28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Peptide Hormones
124 rdf:type schema:DefinedTerm
125 N9a01d24ea12a4bd9a67b5604dbdecdb2 rdf:first sg:person.0706144321.07
126 rdf:rest N54bbf917548d4b6e909be8aa8ed30d66
127 N9da5970068ea44beb138d7f39ddd9717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Peptides
129 rdf:type schema:DefinedTerm
130 Naee7f1c971ad4b5888b8b2140e7f3caf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Rats, Sprague-Dawley
132 rdf:type schema:DefinedTerm
133 Nb2fe92fd5ff34cbe8efb86687453f2b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Animals
135 rdf:type schema:DefinedTerm
136 Ncc3463713055457f96f5d8ee106e27e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Injections, Intraventricular
138 rdf:type schema:DefinedTerm
139 Nceb38ac4c7044e309b5e0bb03571b852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Receptors, Cell Surface
141 rdf:type schema:DefinedTerm
142 Nd3ab48fdf8084e74ba3847f04ce50ecd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Receptors, G-Protein-Coupled
144 rdf:type schema:DefinedTerm
145 Nd70d0eb51e844a47b22c43bd1e77ca6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Food
147 rdf:type schema:DefinedTerm
148 Ne26f6bbbf0934a1d836cbc09b7fc00b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Rats
150 rdf:type schema:DefinedTerm
151 Ne821488c7fb949fc8ffff9efb440b2d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Male
153 rdf:type schema:DefinedTerm
154 Nea6d81136a4346aab79cdacbe8ecb795 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Circadian Rhythm
156 rdf:type schema:DefinedTerm
157 Neb59dd06d6834aad9fff0fd88ed0393f schema:name pubmed_id
158 schema:value 11057670
159 rdf:type schema:PropertyValue
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
164 schema:name Clinical Sciences
165 rdf:type schema:DefinedTerm
166 sg:journal.1018957 schema:issn 0090-0028
167 1476-4687
168 schema:name Nature
169 rdf:type schema:Periodical
170 sg:person.01164056647.53 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
171 schema:familyName Heiman
172 schema:givenName Mark L.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164056647.53
174 rdf:type schema:Person
175 sg:person.013151674377.03 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
176 schema:familyName Tschöp
177 schema:givenName Matthias
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013151674377.03
179 rdf:type schema:Person
180 sg:person.0706144321.07 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
181 schema:familyName Smiley
182 schema:givenName David L.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706144321.07
184 rdf:type schema:Person
185 sg:pub.10.1038/381415a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002805086
186 https://doi.org/10.1038/381415a0
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/45230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039795518
189 https://doi.org/10.1038/45230
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0031-9384(85)90165-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016978838
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0031-9384(93)90264-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1031870674
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0076-6879(87)53067-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044117603
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/0955-2863(91)90016-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030333291
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0167-0115(00)00157-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051066290
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0169-328x(97)00071-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010560713
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s0304-3940(00)00882-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048420564
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1046/j.1365-2826.2000.00398.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018646236
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1056/nejm198912283212605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035706202
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1074/jbc.m002784200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014180586
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/jn/128.2.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083204549
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1126/science.273.5277.974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553900
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1159/000054462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010433221
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1159/000054463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034379577
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1159/000054491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036531128
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1159/000421672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014715010
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1210/endo-116-1-410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064258545
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1210/endo.137.11.8895390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064280608
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1210/jcem.83.11.5265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064321462
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1210/mend.11.4.9908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064331446
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1677/joe.0.1190051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014009589
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1677/joe.0.1500129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050430570
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.417540.3 schema:alternateName Eli Lilly (United States)
236 schema:name Endocrine Research and BioResearch Technologies & Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Drop Code 0545, Indianapolis, Indiana 46285, USA
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...