CD95's deadly mission in the immune system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

P H Krammer

ABSTRACT

Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD95 (Apo-1/Fas)-mediated signalling in T-cell and B-cell development and during the course of an immune response. Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies. More... »

PAGES

789-795

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35037728

    DOI

    http://dx.doi.org/10.1038/35037728

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022325441

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11048730


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