Defying death after DNA damage View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Tina Rich, Rachel L. Allen, Andrew H. Wyllie

ABSTRACT

DNA damage frequently triggers death by apoptosis. The irreversible decision to die can be facilitated or forestalled through integration of a wide variety of stimuli from within and around the cell. Here we address some fundamental questions that arise from this model. Why should DNA damage initiate apoptosis in the first place? In damaged cells, what are the alternatives to death and why should they be selected in some circumstances but not others? What signals register DNA damage and how do they impinge on the effector pathways of apoptosis? Is there a suborganellar apoptosome complex effecting the integration of death signals within the nucleus, just as there is in the cytoplasm? And what are the consequences of failure to initiate apoptosis in response to DNA damage? More... »

PAGES

777-783

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  • Journal

    TITLE

    Nature

    ISSUE

    6805

    VOLUME

    407

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35037717

    DOI

    http://dx.doi.org/10.1038/35037717

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015579370

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11048728


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