Structural determinants of water permeation through aquaporin-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Kazuyoshi Murata, Kaoru Mitsuoka, Teruhisa Hirai, Thomas Walz, Peter Agre, J. Bernard Heymann, Andreas Engel, Yoshinori Fujiyoshi

ABSTRACT

Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data. Multiple highly conserved amino-acid residues stabilize the novel fold of AQP1. The aqueous pathway is lined with conserved hydrophobic residues that permit rapid water transport, whereas the water selectivity is due to a constriction of the pore diameter to about 3 A over a span of one residue. The atomic model provides a possible molecular explanation to a longstanding puzzle in physiology-how membranes can be freely permeable to water but impermeable to protons. More... »

PAGES

599

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35036519

DOI

http://dx.doi.org/10.1038/35036519

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047573149

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11034202


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35036519'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35036519'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35036519'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35036519'


 

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