arrow encodes an LDL-receptor-related protein essential for Wingless signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09

AUTHORS

Marcel Wehrli, Scott T. Dougan, Kim Caldwell, Louise O'Keefe, Stephanie Schwartz, Dalit Vaizel-Ohayon, Eyal Schejter, Andrew Tomlinson, Stephen DiNardo

ABSTRACT

The Wnt family of secreted molecules functions in cell-fate determination and morphogenesis during development in both vertebrates and invertebrates (reviewed in ref. 1). Drosophila Wingless is a founding member of this family, and many components of its signal transduction cascade have been identified, including the Frizzled class of receptor. But the mechanism by which the Wingless signal is received and transduced across the membrane is not completely understood. Here we describe a gene that is necessary for all Wingless signalling events in Drosophila. We show that arrow gene function is essential in cells receiving Wingless input and that it acts upstream of Dishevelled. arrow encodes a single-pass transmembrane protein, indicating that it may be part of a receptor complex with Frizzled class proteins. Arrow is a low-density lipoprotein (LDL)-receptor-related protein (LRP), strikingly homologous to murine and human LRP5 and LRP6. Thus, our data suggests a new and conserved function for this LRP subfamily in Wingless/Wnt signal reception. More... »

PAGES

527

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35035110

DOI

http://dx.doi.org/10.1038/35035110

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019235380

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11029006


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Insect", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, LDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt1 Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "*University of Pennsylvania School of Medicine, BRB II Room 1223, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA", 
            "\u2020Columbia University, 710 West 168th Street, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wehrli", 
        "givenName": "Marcel", 
        "id": "sg:person.01017774230.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017774230.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "\u00a7Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dougan", 
        "givenName": "Scott T.", 
        "id": "sg:person.01217065641.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217065641.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "\u00a7Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caldwell", 
        "givenName": "Kim", 
        "id": "sg:person.0762320245.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762320245.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "\u00a7Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Keefe", 
        "givenName": "Louise", 
        "id": "sg:person.01150752441.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150752441.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "*University of Pennsylvania School of Medicine, BRB II Room 1223, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA", 
            "\u00a7Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "Stephanie", 
        "id": "sg:person.01157630463.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157630463.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "\u2016Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vaizel-Ohayon", 
        "givenName": "Dalit", 
        "id": "sg:person.012076304634.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076304634.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Weizmann Institute of Science", 
          "id": "https://www.grid.ac/institutes/grid.13992.30", 
          "name": [
            "\u2016Weizmann Institute of Science, Rehovot 76100, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schejter", 
        "givenName": "Eyal", 
        "id": "sg:person.01270237121.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270237121.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "\u2020Columbia University, 710 West 168th Street, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomlinson", 
        "givenName": "Andrew", 
        "id": "sg:person.01342172263.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342172263.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Pennsylvania", 
          "id": "https://www.grid.ac/institutes/grid.25879.31", 
          "name": [
            "*University of Pennsylvania School of Medicine, BRB II Room 1223, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA", 
            "\u00a7Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DiNardo", 
        "givenName": "Stephen", 
        "id": "sg:person.0620225463.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620225463.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/geno.1998.5688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000588190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007585285", 
          "https://doi.org/10.1038/41672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/41672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007585285", 
          "https://doi.org/10.1038/41672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35035117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011188142", 
          "https://doi.org/10.1038/35035117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35035117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011188142", 
          "https://doi.org/10.1038/35035117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382162a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011256492", 
          "https://doi.org/10.1038/382162a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80113-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012174978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.21.2758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012298152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90451-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020413008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.1.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023732836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.16.2610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024666603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00848156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027136625", 
          "https://doi.org/10.1007/bf00848156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81991-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031897140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360347a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036878597", 
          "https://doi.org/10.1038/360347a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35035124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039832258", 
          "https://doi.org/10.1038/35035124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35035124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039832258", 
          "https://doi.org/10.1038/35035124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(88)90010-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040260135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041051077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-1119(98)00311-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042518200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81552-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044457896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35008000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048795058", 
          "https://doi.org/10.1038/35008000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35008000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048795058", 
          "https://doi.org/10.1038/35008000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382225a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048857666", 
          "https://doi.org/10.1038/382225a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81438-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050366594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.14.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051239353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a022223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059961024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.273.5280.1373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062554055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074547534", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082460307", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082749174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083049843", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083055868", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083227179", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083370319", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-09", 
    "datePublishedReg": "2000-09-01", 
    "description": "The Wnt family of secreted molecules functions in cell-fate determination and morphogenesis during development in both vertebrates and invertebrates (reviewed in ref. 1). Drosophila Wingless is a founding member of this family, and many components of its signal transduction cascade have been identified, including the Frizzled class of receptor. But the mechanism by which the Wingless signal is received and transduced across the membrane is not completely understood. Here we describe a gene that is necessary for all Wingless signalling events in Drosophila. We show that arrow gene function is essential in cells receiving Wingless input and that it acts upstream of Dishevelled. arrow encodes a single-pass transmembrane protein, indicating that it may be part of a receptor complex with Frizzled class proteins. Arrow is a low-density lipoprotein (LDL)-receptor-related protein (LRP), strikingly homologous to murine and human LRP5 and LRP6. Thus, our data suggests a new and conserved function for this LRP subfamily in Wingless/Wnt signal reception.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/35035110", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2513451", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6803", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "407"
      }
    ], 
    "name": "arrow encodes an LDL-receptor-related protein essential for Wingless\nsignalling", 
    "pagination": "527", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5ba6602b49392095c9a70a7d705f2461d29a4705c06459e712400cc5562fd3e6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11029006"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/35035110"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019235380"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/35035110", 
      "https://app.dimensions.ai/details/publication/pub.1019235380"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87082_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/35035110"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35035110'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35035110'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35035110'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35035110'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      21 PREDICATES      76 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/35035110 schema:about N0e09e16e373e4044a45f02cc97875942
2 N11b7df784f674a938e6c9698563e6ddb
3 N12d9602bc8b14a28b53f65a932080523
4 N59810127f1f048b4a22ca82599dca454
5 N6f9477cb2cba43e38ea584519c51c469
6 N8fa1680be043410c94ce7ba5a6159bf5
7 N90835b2aa81043eb8c7daea66d5abdaa
8 N9bb52951b0fa4453b0c3605df8919628
9 N9c8acb37c02147ad826565c44fc9895b
10 Nb2f4a16180fa4f2fb501c4eb76171258
11 Ncd02a40b2ca140e29a839553cca8f8e1
12 Nd3500a5ac3aa4364948d15a522dbac2b
13 Nd74a5c0d533e4483917a44faa5b39e5c
14 Nd8c30b4eff36448ba9194a8eee9cfbc5
15 Nd90c262490a34ce2917267dafbe2b45b
16 Nd9b0ad0810494b068d20651251f8f875
17 Ndf15b0d42a9b40e7aae6593c57e7ff29
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N161887766f26453eb8019d4655f11350
21 schema:citation sg:pub.10.1007/bf00848156
22 sg:pub.10.1038/35008000
23 sg:pub.10.1038/35035117
24 sg:pub.10.1038/35035124
25 sg:pub.10.1038/360347a0
26 sg:pub.10.1038/382162a0
27 sg:pub.10.1038/382225a0
28 sg:pub.10.1038/41672
29 https://app.dimensions.ai/details/publication/pub.1074547534
30 https://app.dimensions.ai/details/publication/pub.1082460307
31 https://app.dimensions.ai/details/publication/pub.1082749174
32 https://app.dimensions.ai/details/publication/pub.1083049843
33 https://app.dimensions.ai/details/publication/pub.1083055868
34 https://app.dimensions.ai/details/publication/pub.1083227179
35 https://app.dimensions.ai/details/publication/pub.1083370319
36 https://doi.org/10.1006/bbrc.1998.9545
37 https://doi.org/10.1006/geno.1998.5688
38 https://doi.org/10.1016/0022-2836(88)90010-1
39 https://doi.org/10.1016/0092-8674(90)90451-j
40 https://doi.org/10.1016/s0092-8674(00)80113-0
41 https://doi.org/10.1016/s0092-8674(00)81438-5
42 https://doi.org/10.1016/s0092-8674(00)81552-4
43 https://doi.org/10.1016/s0092-8674(00)81991-1
44 https://doi.org/10.1016/s0378-1119(98)00311-4
45 https://doi.org/10.1093/oxfordjournals.jbchem.a022223
46 https://doi.org/10.1101/gad.12.16.2610
47 https://doi.org/10.1101/gad.13.21.2758
48 https://doi.org/10.1101/gad.8.1.118
49 https://doi.org/10.1126/science.273.5280.1373
50 https://doi.org/10.1146/annurev.cellbio.14.1.59
51 schema:datePublished 2000-09
52 schema:datePublishedReg 2000-09-01
53 schema:description The Wnt family of secreted molecules functions in cell-fate determination and morphogenesis during development in both vertebrates and invertebrates (reviewed in ref. 1). Drosophila Wingless is a founding member of this family, and many components of its signal transduction cascade have been identified, including the Frizzled class of receptor. But the mechanism by which the Wingless signal is received and transduced across the membrane is not completely understood. Here we describe a gene that is necessary for all Wingless signalling events in Drosophila. We show that arrow gene function is essential in cells receiving Wingless input and that it acts upstream of Dishevelled. arrow encodes a single-pass transmembrane protein, indicating that it may be part of a receptor complex with Frizzled class proteins. Arrow is a low-density lipoprotein (LDL)-receptor-related protein (LRP), strikingly homologous to murine and human LRP5 and LRP6. Thus, our data suggests a new and conserved function for this LRP subfamily in Wingless/Wnt signal reception.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N1b873bf2448c4dae88e32d0a6a918557
58 Nbdccabd097b242f5a732b23f990be544
59 sg:journal.1018957
60 schema:name arrow encodes an LDL-receptor-related protein essential for Wingless signalling
61 schema:pagination 527
62 schema:productId N1f33787c432e4dc19256ac86bca19294
63 N310e681236e04b9193f6b177908ca5ef
64 N4247c8c588e44846aee07b7f54cc89f3
65 N51d0fa41f57a4464961b397ec41c8a8e
66 Nd41e06a404c849f1bd3103e841280439
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019235380
68 https://doi.org/10.1038/35035110
69 schema:sdDatePublished 2019-04-11T12:21
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N3b07dcf7e01a4a0a9c20ac9b35cca6ff
72 schema:url https://www.nature.com/articles/35035110
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N03179b28e6314dc68d67304b07b54d2f rdf:first sg:person.01150752441.05
77 rdf:rest Nf89cc4c8c7e5474e9133f8b0bd3bc13a
78 N0e09e16e373e4044a45f02cc97875942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Male
80 rdf:type schema:DefinedTerm
81 N11b7df784f674a938e6c9698563e6ddb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Signal Transduction
83 rdf:type schema:DefinedTerm
84 N12d9602bc8b14a28b53f65a932080523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Membrane Proteins
86 rdf:type schema:DefinedTerm
87 N161887766f26453eb8019d4655f11350 rdf:first sg:person.01017774230.94
88 rdf:rest N64aaec63557b49ed8d1d2653f33ba5d8
89 N1718d7ca92d94bb194915e2939689a1e rdf:first sg:person.01342172263.29
90 rdf:rest N19c43276179c451294b0ea82dd9c38ca
91 N172f0a9a97424555b91a780c322a209c schema:name §Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA
92 rdf:type schema:Organization
93 N19c43276179c451294b0ea82dd9c38ca rdf:first sg:person.0620225463.33
94 rdf:rest rdf:nil
95 N1b873bf2448c4dae88e32d0a6a918557 schema:issueNumber 6803
96 rdf:type schema:PublicationIssue
97 N1f33787c432e4dc19256ac86bca19294 schema:name dimensions_id
98 schema:value pub.1019235380
99 rdf:type schema:PropertyValue
100 N21103e8e760f42838788bc25ec8c6fa1 schema:name §Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA
101 rdf:type schema:Organization
102 N211ffdf1710549f18dfbfaf89d0cc9ff schema:name §Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA
103 rdf:type schema:Organization
104 N310e681236e04b9193f6b177908ca5ef schema:name readcube_id
105 schema:value 5ba6602b49392095c9a70a7d705f2461d29a4705c06459e712400cc5562fd3e6
106 rdf:type schema:PropertyValue
107 N3b07dcf7e01a4a0a9c20ac9b35cca6ff schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N4247c8c588e44846aee07b7f54cc89f3 schema:name pubmed_id
110 schema:value 11029006
111 rdf:type schema:PropertyValue
112 N51d0fa41f57a4464961b397ec41c8a8e schema:name nlm_unique_id
113 schema:value 0410462
114 rdf:type schema:PropertyValue
115 N59810127f1f048b4a22ca82599dca454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Genes, Insect
117 rdf:type schema:DefinedTerm
118 N64aaec63557b49ed8d1d2653f33ba5d8 rdf:first sg:person.01217065641.00
119 rdf:rest Nb82110a38102485baadfc5cdbf0eb8f8
120 N6f9477cb2cba43e38ea584519c51c469 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Sequence Homology, Amino Acid
122 rdf:type schema:DefinedTerm
123 N8fa1680be043410c94ce7ba5a6159bf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice
125 rdf:type schema:DefinedTerm
126 N90835b2aa81043eb8c7daea66d5abdaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Proto-Oncogene Proteins
128 rdf:type schema:DefinedTerm
129 N9664bf79e12645feb98db34b98423798 rdf:first sg:person.012076304634.52
130 rdf:rest Naeab1451a3044649848e85dcf5d4fb95
131 N9bb52951b0fa4453b0c3605df8919628 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Receptors, LDL
133 rdf:type schema:DefinedTerm
134 N9c8acb37c02147ad826565c44fc9895b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Insect Proteins
136 rdf:type schema:DefinedTerm
137 Naeab1451a3044649848e85dcf5d4fb95 rdf:first sg:person.01270237121.05
138 rdf:rest N1718d7ca92d94bb194915e2939689a1e
139 Nb2f4a16180fa4f2fb501c4eb76171258 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Drosophila Proteins
141 rdf:type schema:DefinedTerm
142 Nb82110a38102485baadfc5cdbf0eb8f8 rdf:first sg:person.0762320245.51
143 rdf:rest N03179b28e6314dc68d67304b07b54d2f
144 Nbdccabd097b242f5a732b23f990be544 schema:volumeNumber 407
145 rdf:type schema:PublicationVolume
146 Ncd02a40b2ca140e29a839553cca8f8e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 Nd3500a5ac3aa4364948d15a522dbac2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cloning, Molecular
151 rdf:type schema:DefinedTerm
152 Nd41e06a404c849f1bd3103e841280439 schema:name doi
153 schema:value 10.1038/35035110
154 rdf:type schema:PropertyValue
155 Nd74a5c0d533e4483917a44faa5b39e5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Wnt1 Protein
157 rdf:type schema:DefinedTerm
158 Nd8c30b4eff36448ba9194a8eee9cfbc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Drosophila
160 rdf:type schema:DefinedTerm
161 Nd90c262490a34ce2917267dafbe2b45b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Molecular Sequence Data
163 rdf:type schema:DefinedTerm
164 Nd9b0ad0810494b068d20651251f8f875 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 Ndf15b0d42a9b40e7aae6593c57e7ff29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Differentiation
169 rdf:type schema:DefinedTerm
170 Nf89cc4c8c7e5474e9133f8b0bd3bc13a rdf:first sg:person.01157630463.87
171 rdf:rest N9664bf79e12645feb98db34b98423798
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biochemistry and Cell Biology
177 rdf:type schema:DefinedTerm
178 sg:grant.2513451 http://pending.schema.org/fundedItem sg:pub.10.1038/35035110
179 rdf:type schema:MonetaryGrant
180 sg:journal.1018957 schema:issn 0090-0028
181 1476-4687
182 schema:name Nature
183 rdf:type schema:Periodical
184 sg:person.01017774230.94 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
185 schema:familyName Wehrli
186 schema:givenName Marcel
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017774230.94
188 rdf:type schema:Person
189 sg:person.01150752441.05 schema:affiliation N211ffdf1710549f18dfbfaf89d0cc9ff
190 schema:familyName O'Keefe
191 schema:givenName Louise
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150752441.05
193 rdf:type schema:Person
194 sg:person.01157630463.87 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
195 schema:familyName Schwartz
196 schema:givenName Stephanie
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157630463.87
198 rdf:type schema:Person
199 sg:person.012076304634.52 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
200 schema:familyName Vaizel-Ohayon
201 schema:givenName Dalit
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012076304634.52
203 rdf:type schema:Person
204 sg:person.01217065641.00 schema:affiliation N172f0a9a97424555b91a780c322a209c
205 schema:familyName Dougan
206 schema:givenName Scott T.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217065641.00
208 rdf:type schema:Person
209 sg:person.01270237121.05 schema:affiliation https://www.grid.ac/institutes/grid.13992.30
210 schema:familyName Schejter
211 schema:givenName Eyal
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270237121.05
213 rdf:type schema:Person
214 sg:person.01342172263.29 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
215 schema:familyName Tomlinson
216 schema:givenName Andrew
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342172263.29
218 rdf:type schema:Person
219 sg:person.0620225463.33 schema:affiliation https://www.grid.ac/institutes/grid.25879.31
220 schema:familyName DiNardo
221 schema:givenName Stephen
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620225463.33
223 rdf:type schema:Person
224 sg:person.0762320245.51 schema:affiliation N21103e8e760f42838788bc25ec8c6fa1
225 schema:familyName Caldwell
226 schema:givenName Kim
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762320245.51
228 rdf:type schema:Person
229 sg:pub.10.1007/bf00848156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027136625
230 https://doi.org/10.1007/bf00848156
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/35008000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048795058
233 https://doi.org/10.1038/35008000
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/35035117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011188142
236 https://doi.org/10.1038/35035117
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/35035124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039832258
239 https://doi.org/10.1038/35035124
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/360347a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036878597
242 https://doi.org/10.1038/360347a0
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/382162a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011256492
245 https://doi.org/10.1038/382162a0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/382225a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048857666
248 https://doi.org/10.1038/382225a0
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/41672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007585285
251 https://doi.org/10.1038/41672
252 rdf:type schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1074547534 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082460307 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082749174 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1083049843 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1083055868 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1083227179 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1083370319 schema:CreativeWork
260 https://doi.org/10.1006/bbrc.1998.9545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041051077
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1006/geno.1998.5688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000588190
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0022-2836(88)90010-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040260135
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/0092-8674(90)90451-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1020413008
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0092-8674(00)80113-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012174978
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0092-8674(00)81438-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050366594
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(00)81552-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044457896
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0092-8674(00)81991-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031897140
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0378-1119(98)00311-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042518200
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/oxfordjournals.jbchem.a022223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059961024
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1101/gad.12.16.2610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024666603
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1101/gad.13.21.2758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012298152
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1101/gad.8.1.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023732836
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.273.5280.1373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062554055
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1146/annurev.cellbio.14.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051239353
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.13992.30 schema:alternateName Weizmann Institute of Science
291 schema:name ‖Weizmann Institute of Science, Rehovot 76100, Israel
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
294 schema:name *University of Pennsylvania School of Medicine, BRB II Room 1223, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
295 †Columbia University, 710 West 168th Street, New York, New York 10032, USA
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.25879.31 schema:alternateName University of Pennsylvania
298 schema:name *University of Pennsylvania School of Medicine, BRB II Room 1223, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
299 §Rockefeller University, 1230 York Avenue, New York. New York, 10021 , USA
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...