Microbiology: A triclosan-resistant bacterial enzyme View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-07

AUTHORS

Richard J. Heath, Charles O. Rock

ABSTRACT

Triclosan is an antimicrobial agent that is widely used in a variety of consumer products and acts by inhibiting one of the highly conserved enzymes (enoyl-ACP reductase, or FabI) of bacterial fatty-acid biosynthesis. But several key pathogenic bacteria do not possess FabI, and here we describe a unique triclosan-resistant flavoprotein, FabK, that can also catalyse this reaction in Streptococcus pneumoniae. Our finding has implications for the development of FabI-specific inhibitors as antibacterial agents. More... »

PAGES

145-146

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35018162

DOI

http://dx.doi.org/10.1038/35018162

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013380240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10910344


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