Modulation of retinoid signalling through NGF-induced nuclear export of NGFI-B View Full Text


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Article Info

DATE

2000-07

AUTHORS

Gordon Guroff, Kazuyo Takeda, Keiko Ozato, Victor J. Ferrans, Yasuhiro Katagiri, Zu-Xi Yu

ABSTRACT

The retinoid-X receptor (RXR) regulates multiple hormonal pathways through heterodimerization with nuclear receptors such as the all-trans retinoic acid receptor (RAR). The orphan nuclear receptor NGFI-B (also called Nur77) can heterodimerize with RXR. Here we show that nerve growth factor (NGF) induces the phosphorylation of Ser 105 of NGFI-B in PC12 phaeochromocytoma cells, resulting in translocation of the NGFI-B-RXR heterodimer complex out of the nucleus using nuclear export signals within NGFI-B. As a consequence of the redistribution of RXR, the transcriptional activity of RXR-RAR is reduced. NGFI-B-mediated nuclear export of receptors may serve as a mechanism for crosstalk between NGF and retinoid pathways. More... »

PAGES

435

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35017072

DOI

http://dx.doi.org/10.1038/35017072

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032902878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10878809


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