Population genetics: Malaria susceptibility and CD36 mutation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-06

AUTHORS

Timothy J. Aitman, Lisa D. Cooper, Penny J. Norsworthy, Faisal N. Wahid, Jennefer K. Gray, Brian R. Curtis, Paul M McKeigue, Dominic Kwiatkowski, Brian M. Greenwood, Robert W. Snow, Adrian V Hill, James Scott

ABSTRACT

A critical step in infection by Plasmodium falciparum, the microorganism that causes the most severe form of malaria, is the adhesion of parasitized red blood cells to capillary endothelium. The human protein CD36 is a major receptor for P. falciparum-infected red blood cells1,2 and may contribute to the disease by sequestering infected red blood cells1,2 and inhibiting the immune response to the parasite3. We have found that African populations contain an exceptionally high frequency of mutations in CD36. Unexpectedly, these mutations that cause CD36 deficiency are associated with susceptibility to severe malaria, suggesting that the presence of distinct CD36 mutations in Africans and Asians4,5,6 is due to some selection pressure other than malaria. More... »

PAGES

1015-1016

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35016636

DOI

http://dx.doi.org/10.1038/35016636

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038469462

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10890433


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