Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-06

AUTHORS

Stacey S. Huppert, Anh Le, Eric H. Schroeter, Jeffrey S. Mumm, Meera T. Saxena, Laurie A. Milner, Raphael Kopan

ABSTRACT

The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for the Notch signalling pathway. One paradigm is that ligand binding to Notch triggers a Presenilin1-dependent proteolytic release of the Notch intracellular domain from the membrane1, resulting in low amounts of Notch intracellular domain which form a nuclear complex with CBF1/Su(H)/Lag1 to activate transcription of downstream targets2. Not all observations clearly support this processing model, and the most rigorous test of it is to block processing in vivo and then determine the ability of unprocessed Notch to signal. Here we report that the phenotypes associated with a single point mutation at the intramembranous processing site of Notch1, Val1,744→Gly, resemble the null Notch1 phenotype3,4. Our results show that efficient intramembranous processing of Notch1 is indispensable for embryonic viability and proper early embryonic development in vivo. More... »

PAGES

966-970

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35016111

DOI

http://dx.doi.org/10.1038/35016111

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042481749

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10879540


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic and Fetal Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Targeting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ-Line Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Point Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Processing, Post-Translational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Notch1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cytokine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huppert", 
        "givenName": "Stacey S.", 
        "id": "sg:person.01051101443.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051101443.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Le", 
        "givenName": "Anh", 
        "id": "sg:person.01272573531.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272573531.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schroeter", 
        "givenName": "Eric H.", 
        "id": "sg:person.0742772124.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742772124.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mumm", 
        "givenName": "Jeffrey S.", 
        "id": "sg:person.013366335604.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013366335604.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saxena", 
        "givenName": "Meera T.", 
        "id": "sg:person.01003776647.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003776647.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milner", 
        "givenName": "Laurie A.", 
        "id": "sg:person.01217401477.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217401477.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kopan", 
        "givenName": "Raphael", 
        "id": "sg:person.0660157721.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660157721.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/30756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041325757", 
          "https://doi.org/10.1038/30756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004270050120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022308235", 
          "https://doi.org/10.1007/s004270050120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/377355a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019765251", 
          "https://doi.org/10.1038/377355a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048748829", 
          "https://doi.org/10.1038/19083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/380435a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034005847", 
          "https://doi.org/10.1038/380435a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034939896", 
          "https://doi.org/10.1038/19096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1097-223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015974602", 
          "https://doi.org/10.1038/ng1097-223"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-06", 
    "datePublishedReg": "2000-06-01", 
    "description": "The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for the Notch signalling pathway. One paradigm is that ligand binding to Notch triggers a Presenilin1-dependent proteolytic release of the Notch intracellular domain from the membrane1, resulting in low amounts of Notch intracellular domain which form a nuclear complex with CBF1/Su(H)/Lag1 to activate transcription of downstream targets2. Not all observations clearly support this processing model, and the most rigorous test of it is to block processing in vivo and then determine the ability of unprocessed Notch to signal. Here we report that the phenotypes associated with a single point mutation at the intramembranous processing site of Notch1, Val1,744\u2192Gly, resemble the null Notch1 phenotype3,4. Our results show that efficient intramembranous processing of Notch1 is indispensable for embryonic viability and proper early embryonic development in vivo.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/35016111", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6789", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "405"
      }
    ], 
    "keywords": [
      "Notch intracellular domain", 
      "extracellular signals", 
      "intracellular domain", 
      "single-pass transmembrane receptors", 
      "cell fate determination", 
      "cell fate decisions", 
      "early embryonic development", 
      "single point mutation", 
      "CBF1/", 
      "metazoan development", 
      "fate determination", 
      "fate decisions", 
      "Notch genes", 
      "embryonic lethality", 
      "embryonic development", 
      "transmembrane receptors", 
      "gene transcription", 
      "embryonic viability", 
      "proteolytic release", 
      "point mutations", 
      "intramembranous processing", 
      "processing site", 
      "notch triggers", 
      "transcription", 
      "Notch1", 
      "nuclear complex", 
      "vivo", 
      "Notch", 
      "genes", 
      "membrane1", 
      "domain", 
      "mutations", 
      "phenotype", 
      "lethality", 
      "low amounts", 
      "alleles", 
      "pathway", 
      "rigorous test", 
      "receptors", 
      "complexes", 
      "viability", 
      "sites", 
      "signals", 
      "development", 
      "mechanism", 
      "mice", 
      "ligands", 
      "triggers", 
      "release", 
      "ability", 
      "step", 
      "amount", 
      "observations", 
      "processing", 
      "results", 
      "determination", 
      "paradigm", 
      "model", 
      "test", 
      "decisions", 
      "processing model"
    ], 
    "name": "Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1", 
    "pagination": "966-970", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042481749"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/35016111"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10879540"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/35016111", 
      "https://app.dimensions.ai/details/publication/pub.1042481749"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_330.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/35016111"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35016111'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35016111'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35016111'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35016111'


 

This table displays all metadata directly associated to this object as RDF triples.

282 TRIPLES      21 PREDICATES      116 URIs      101 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/35016111 schema:about N03c3297575474d7a91869b537896599e
2 N0a2b1bddf922430b833df360da45c720
3 N0c69cc8181884d1085d91867765734e4
4 N0f7bb11a85734698b1d8ead9c444178f
5 N102fbfa593e54316959a19d98f0a0dc7
6 N14ea6e0e31e84b278ae7befdfa1dfd6d
7 N2004f248fe134fdb90253185f138945f
8 N235b0030c9f64fd0bfef3a271deac11d
9 N416aaf11525044e8a4eebaf4c603395d
10 N4adf870d3e7043ed8c7fb0565f5091b9
11 N5ff55ccbaee94fc0ab14a255470c871f
12 N60bf20501553445e9649a8df95281931
13 N84f1e37e27ec4c46ba9abd4abdb47191
14 N8fed94edc52240f987aedc82d98a0c34
15 N969fdd463060479fbcc0f24643d06a74
16 N997d648b2adb49b49ca9bc06046bb112
17 N9dd4b347d14242eca9beb3dbe7bc04a7
18 Na1e44001a3724a378095f167a5dcf9ad
19 Ncbef59a967584212a6af420173a55ebc
20 Ncc7507fe51864c5388fe73b4cfed15d0
21 Ne77413cbc52e4782bbb753a73ac3e182
22 Nf125e466d5ff44c6a82782cc1b4508a7
23 anzsrc-for:06
24 anzsrc-for:0604
25 schema:author Nd8e97e7df4eb481d984994a44079c7a1
26 schema:citation sg:pub.10.1007/s004270050120
27 sg:pub.10.1038/19083
28 sg:pub.10.1038/19096
29 sg:pub.10.1038/30756
30 sg:pub.10.1038/377355a0
31 sg:pub.10.1038/380435a0
32 sg:pub.10.1038/ng1097-223
33 schema:datePublished 2000-06
34 schema:datePublishedReg 2000-06-01
35 schema:description The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for the Notch signalling pathway. One paradigm is that ligand binding to Notch triggers a Presenilin1-dependent proteolytic release of the Notch intracellular domain from the membrane1, resulting in low amounts of Notch intracellular domain which form a nuclear complex with CBF1/Su(H)/Lag1 to activate transcription of downstream targets2. Not all observations clearly support this processing model, and the most rigorous test of it is to block processing in vivo and then determine the ability of unprocessed Notch to signal. Here we report that the phenotypes associated with a single point mutation at the intramembranous processing site of Notch1, Val1,744→Gly, resemble the null Notch1 phenotype3,4. Our results show that efficient intramembranous processing of Notch1 is indispensable for embryonic viability and proper early embryonic development in vivo.
36 schema:genre article
37 schema:isAccessibleForFree false
38 schema:isPartOf N30bafd60f08e491e933cf431ed452137
39 Ncd432a421ae14201ab0c89650d0e9c71
40 sg:journal.1018957
41 schema:keywords CBF1/
42 Notch
43 Notch genes
44 Notch intracellular domain
45 Notch1
46 ability
47 alleles
48 amount
49 cell fate decisions
50 cell fate determination
51 complexes
52 decisions
53 determination
54 development
55 domain
56 early embryonic development
57 embryonic development
58 embryonic lethality
59 embryonic viability
60 extracellular signals
61 fate decisions
62 fate determination
63 gene transcription
64 genes
65 intracellular domain
66 intramembranous processing
67 lethality
68 ligands
69 low amounts
70 mechanism
71 membrane1
72 metazoan development
73 mice
74 model
75 mutations
76 notch triggers
77 nuclear complex
78 observations
79 paradigm
80 pathway
81 phenotype
82 point mutations
83 processing
84 processing model
85 processing site
86 proteolytic release
87 receptors
88 release
89 results
90 rigorous test
91 signals
92 single point mutation
93 single-pass transmembrane receptors
94 sites
95 step
96 test
97 transcription
98 transmembrane receptors
99 triggers
100 viability
101 vivo
102 schema:name Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
103 schema:pagination 966-970
104 schema:productId N0124a90c86bc4a77b433d2b0d66b1951
105 N178425a309dd47ce925097d441fae690
106 Nafc1bee47e784857808674989d2ae514
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042481749
108 https://doi.org/10.1038/35016111
109 schema:sdDatePublished 2022-10-01T06:31
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Nce691ba23603459b93075c7dd3b345f3
112 schema:url https://doi.org/10.1038/35016111
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N0124a90c86bc4a77b433d2b0d66b1951 schema:name pubmed_id
117 schema:value 10879540
118 rdf:type schema:PropertyValue
119 N03c3297575474d7a91869b537896599e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Transcription Factors
121 rdf:type schema:DefinedTerm
122 N0a2b1bddf922430b833df360da45c720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Receptor, Notch1
124 rdf:type schema:DefinedTerm
125 N0c69cc8181884d1085d91867765734e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Membrane Proteins
127 rdf:type schema:DefinedTerm
128 N0f7bb11a85734698b1d8ead9c444178f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Point Mutation
130 rdf:type schema:DefinedTerm
131 N102fbfa593e54316959a19d98f0a0dc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Animals
133 rdf:type schema:DefinedTerm
134 N14ea6e0e31e84b278ae7befdfa1dfd6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Mice
136 rdf:type schema:DefinedTerm
137 N178425a309dd47ce925097d441fae690 schema:name doi
138 schema:value 10.1038/35016111
139 rdf:type schema:PropertyValue
140 N2004f248fe134fdb90253185f138945f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Alleles
142 rdf:type schema:DefinedTerm
143 N235b0030c9f64fd0bfef3a271deac11d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cloning, Molecular
145 rdf:type schema:DefinedTerm
146 N30bafd60f08e491e933cf431ed452137 schema:issueNumber 6789
147 rdf:type schema:PublicationIssue
148 N416aaf11525044e8a4eebaf4c603395d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Processing, Post-Translational
150 rdf:type schema:DefinedTerm
151 N4adf870d3e7043ed8c7fb0565f5091b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Phenotype
153 rdf:type schema:DefinedTerm
154 N5ff55ccbaee94fc0ab14a255470c871f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Embryo, Mammalian
156 rdf:type schema:DefinedTerm
157 N60bf20501553445e9649a8df95281931 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Immunoglobulins
159 rdf:type schema:DefinedTerm
160 N75b75c9cb872478c9931e60cba5199af rdf:first sg:person.0742772124.34
161 rdf:rest Nda3a5515b37d4058b6c6714b264641ac
162 N84f1e37e27ec4c46ba9abd4abdb47191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Germ-Line Mutation
164 rdf:type schema:DefinedTerm
165 N8fed94edc52240f987aedc82d98a0c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Targeting
167 rdf:type schema:DefinedTerm
168 N969fdd463060479fbcc0f24643d06a74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mice, Inbred C57BL
170 rdf:type schema:DefinedTerm
171 N997d648b2adb49b49ca9bc06046bb112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Fetal Death
173 rdf:type schema:DefinedTerm
174 N9dd4b347d14242eca9beb3dbe7bc04a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Embryonic and Fetal Development
176 rdf:type schema:DefinedTerm
177 Na1e44001a3724a378095f167a5dcf9ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name In Situ Hybridization
179 rdf:type schema:DefinedTerm
180 Nafc1bee47e784857808674989d2ae514 schema:name dimensions_id
181 schema:value pub.1042481749
182 rdf:type schema:PropertyValue
183 Nb57f740c795a48eabd982ac4e599aee7 rdf:first sg:person.01217401477.39
184 rdf:rest Nfd4012e6469c451d82a45439a4c0e899
185 Ncbef59a967584212a6af420173a55ebc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Ligands
187 rdf:type schema:DefinedTerm
188 Ncc7507fe51864c5388fe73b4cfed15d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Receptors, Cell Surface
190 rdf:type schema:DefinedTerm
191 Ncd432a421ae14201ab0c89650d0e9c71 schema:volumeNumber 405
192 rdf:type schema:PublicationVolume
193 Nce691ba23603459b93075c7dd3b345f3 schema:name Springer Nature - SN SciGraph project
194 rdf:type schema:Organization
195 Nd8e97e7df4eb481d984994a44079c7a1 rdf:first sg:person.01051101443.46
196 rdf:rest Nd922ea434bc0482c92f1af7145c2940a
197 Nd922ea434bc0482c92f1af7145c2940a rdf:first sg:person.01272573531.09
198 rdf:rest N75b75c9cb872478c9931e60cba5199af
199 Nd9668e817b794dec8857102b0fe58ebb rdf:first sg:person.01003776647.41
200 rdf:rest Nb57f740c795a48eabd982ac4e599aee7
201 Nda3a5515b37d4058b6c6714b264641ac rdf:first sg:person.013366335604.54
202 rdf:rest Nd9668e817b794dec8857102b0fe58ebb
203 Ne77413cbc52e4782bbb753a73ac3e182 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Receptors, Cytokine
205 rdf:type schema:DefinedTerm
206 Nf125e466d5ff44c6a82782cc1b4508a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Homozygote
208 rdf:type schema:DefinedTerm
209 Nfd4012e6469c451d82a45439a4c0e899 rdf:first sg:person.0660157721.51
210 rdf:rest rdf:nil
211 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biological Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
215 schema:name Genetics
216 rdf:type schema:DefinedTerm
217 sg:journal.1018957 schema:issn 0028-0836
218 1476-4687
219 schema:name Nature
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.01003776647.41 schema:affiliation grid-institutes:grid.4367.6
223 schema:familyName Saxena
224 schema:givenName Meera T.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003776647.41
226 rdf:type schema:Person
227 sg:person.01051101443.46 schema:affiliation grid-institutes:grid.4367.6
228 schema:familyName Huppert
229 schema:givenName Stacey S.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051101443.46
231 rdf:type schema:Person
232 sg:person.01217401477.39 schema:affiliation grid-institutes:grid.34477.33
233 schema:familyName Milner
234 schema:givenName Laurie A.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217401477.39
236 rdf:type schema:Person
237 sg:person.01272573531.09 schema:familyName Le
238 schema:givenName Anh
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272573531.09
240 rdf:type schema:Person
241 sg:person.013366335604.54 schema:affiliation grid-institutes:grid.4367.6
242 schema:familyName Mumm
243 schema:givenName Jeffrey S.
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013366335604.54
245 rdf:type schema:Person
246 sg:person.0660157721.51 schema:affiliation grid-institutes:grid.4367.6
247 schema:familyName Kopan
248 schema:givenName Raphael
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660157721.51
250 rdf:type schema:Person
251 sg:person.0742772124.34 schema:affiliation grid-institutes:grid.4367.6
252 schema:familyName Schroeter
253 schema:givenName Eric H.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742772124.34
255 rdf:type schema:Person
256 sg:pub.10.1007/s004270050120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022308235
257 https://doi.org/10.1007/s004270050120
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/19083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048748829
260 https://doi.org/10.1038/19083
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/19096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034939896
263 https://doi.org/10.1038/19096
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/30756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041325757
266 https://doi.org/10.1038/30756
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/377355a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019765251
269 https://doi.org/10.1038/377355a0
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/380435a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034005847
272 https://doi.org/10.1038/380435a0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/ng1097-223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015974602
275 https://doi.org/10.1038/ng1097-223
276 rdf:type schema:CreativeWork
277 grid-institutes:grid.34477.33 schema:alternateName The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, 98109, Seattle, Washington, USA
278 schema:name The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, 98109, Seattle, Washington, USA
279 rdf:type schema:Organization
280 grid-institutes:grid.4367.6 schema:alternateName Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA
281 schema:name Department of Molecular Biology and Pharmacology and the Department of Medicine (Division of Dermatology) Washington University School of Medicine, 63110, St Louis, Missouri, USA
282 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...