Stable germline transformation of the malaria mosquito Anopheles stephensi View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-06

AUTHORS

F Catteruccia, T Nolan, T G Loukeris, C Blass, C Savakis, F C Kafatos, A Crisanti

ABSTRACT

Anopheline mosquito species are obligatory vectors for human malaria, an infectious disease that affects hundreds of millions of people living in tropical and subtropical countries. The lack of a suitable gene transfer technology for these mosquitoes has hampered the molecular genetic analysis of their physiology, including the molecular interactions between the vector and the malaria parasite. Here we show that a transposon, based on the Minos element and bearing exogenous DNA, can integrate efficiently and stably into the germ line of the human malaria vector Anopheles stephensi, through a transposase-mediated process. More... »

PAGES

959

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35016096

DOI

http://dx.doi.org/10.1038/35016096

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044128944

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10879538


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