Enzyme catalysis: not different, just better View Full Text


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Article Info

DATE

1991-03

AUTHORS

Jeremy R. Knowles

ABSTRACT

Where are we in our understanding of enzyme catalysis? The gloomier view is that protein structure and enzyme function are the finely balanced end-products of many weak interactions that can be summed only by massive computing power, and more precise parameterization than we enjoy at present. The cheerier position is that proteins are built on definable principles, and that enzymes use recognizable catalytic devices that will allow us to understand how existing enzymes work and to design new ones. To assess which interpretation is the more realistic, the simple reaction catalysed by triosephosphate isomerase is considered here. This examination illustrates some of the catalytic features of enzymes that are understood, and exposes a few that are not. But overall, the question turns out to have an optimistic answer. More... »

PAGES

121-124

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/350121a0

DOI

http://dx.doi.org/10.1038/350121a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040243088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2005961


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