PDGF-C is a new protease-activated ligand for the PDGF α-receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04-07

AUTHORS

Xuri Li, Annica Pontén, Karin Aase, Linda Karlsson, Alexandra Abramsson, Marko Uutela, Gudrun Bäckström, Mats Hellström, Hans Boström, Hong Li, Philippe Soriano, Christer Betsholtz, Carl-Henrik Heldin, Kari Alitalo, Arne Östman, Ulf Eriksson

ABSTRACT

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF α-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function. More... »

PAGES

302-309

Journal

TITLE

Nature Cell Biology

ISSUE

5

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35010579

DOI

http://dx.doi.org/10.1038/35010579

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017745355

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10806482


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33 schema:description Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF α-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF α-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.
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