Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

L Blanchoin, K J Amann, H N Higgs, J B Marchand, D A Kaiser, T D Pollard

ABSTRACT

Most nucleated cells crawl about by extending a pseudopod that is driven by the polymerization of actin filaments in the cytoplasm behind the leading edge of the plasma membrane. These actin filaments are linked into a network by Y-branches, with the pointed end of each filament attached to the side of another filament and the rapidly growing barbed end facing forward. Because Arp2/3 complex nucleates actin polymerization and links the pointed end to the side of another filament in vitro, a dendritic nucleation model has been proposed in which Arp2/3 complex initiates filaments from the sides of older filaments. Here we report, by using a light microscopy assay, many new features of the mechanism. Branching occurs during, rather than after, nucleation by Arp2/3 complex activated by the Wiskott-Aldrich syndrome protein (WASP) or Scar protein; capping protein and profilin act synergistically with Arp2/3 complex to favour branched nucleation; phosphate release from aged actin filaments favours dissociation of Arp2/3 complex from the pointed ends of filaments; and branches created by Arp2/3 complex are relatively rigid. These properties result in the automatic assembly of the branched actin network after activation by proteins of the WASP/Scar family and favour the selective disassembly of proximal regions of the network. More... »

PAGES

1007

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35010008

DOI

http://dx.doi.org/10.1038/35010008

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049252125

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10801131


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