Central nervous system control of food intake View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

M W Schwartz, S C Woods, D Porte, R J Seeley, D G Baskin

ABSTRACT

New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby energy intake is matched to energy expenditure over time. The profound obesity that results in rodents (and in the rare human case as well) from mutation of key signalling molecules involved in this regulatory system highlights its importance to human health. Although each new signalling pathway discovered in the hypothalamus is a potential target for drug development in the treatment of obesity, the growing number of such signalling molecules indicates that food intake is controlled by a highly complex process. To better understand how energy homeostasis can be achieved, we describe a model that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function. More... »

PAGES

661-671

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  • Journal

    TITLE

    Nature

    ISSUE

    6778

    VOLUME

    404

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35007534

    DOI

    http://dx.doi.org/10.1038/35007534

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036745532

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10766253


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