Obesity as a medical problem View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

Peter G. Kopelman

ABSTRACT

Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. Obesity is defined by a body-mass index (weight divided by square of the height) of 30 kg m−2 or greater, but this does not take into account the morbidity and mortality associated with more modest degrees of overweight, nor the detrimental effect of intra-abdominal fat. The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals, but an epidemic that threatens global well being. More... »

PAGES

635-643

Journal

TITLE

Nature

ISSUE

6778

VOLUME

404

Related Patents

  • Non-Invasive Scanning Apparatuses
  • Combination Of Gpr119 Agonist With A Dipeptidyl Peptidase Iv (Dpp-Iv) Inhibitor Such That Combination Provides Effect In Lowering A Blood Glucose Level Or In Increasing Blood Glp-1 Level Over That Provided By Gpr119 Agonist Or Dpp-Iv Inhibitor Alone; For Treating Or Preventing Diabetes; Synergistic
  • Non-Invasive Weight And Performance Management
  • Non-Invasive Determination Of Characteristics Of A Sample
  • Compositions And Methods For Prevention And Treatment Of Obesity And Obesity Related Metabolic Syndrome
  • Methods And Reagents For Treating Glucose Metabolic Disorders
  • Combination Therapy For The Treatment Of Diabetes And Conditions Related Thereto And For The Treatment Of Conditions Ameliorated By Increasing A Blood Glp-1 Level
  • Identifying A Glucose-Dependent Insulinotropic Peptide (Gip) Secretagogue; G Protein-Coupled Receptor (Gpcr); Useful As Therapeutic Agents For Treating Or Preventing A Condition Characterized By Low Bone Mass, Such As Osteoporosis
  • Methods For Manipulating Upper Gastrointestinal Transit, Blood Flow, And Satiety, And For Treating Visceral Hyperalgesia
  • Antilipemic Agents; Anticholesterol Agents; Antidiabetic Agents; Hypotensive Agents; Administering Polypeptide; Useful For Treating Obesity-Related Diseases And Disorders
  • Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same
  • Methods For Identifying Glp-1 Secretagogues
  • Obg3 Globular Head And Uses Thereof
  • Lowering Circulating Free Fatty Acid Levels In An Individual By Administering To Polypeptide And Carrier
  • Methods Of Treating Obesity Using Pyy[3-36]
  • Treating Osteoporosis, Rheumatoid Arthritis, Osteoarthritis, Periodontal Disease, Alveolar Bone Loss, Osteotomy Bone Loss, Childhood Idiopathic Bone Loss, Paget's Disease, Bone Loss Due To Metastatic Cancer, Osteolytic Lesions, Using Gpr119 Agonist In Combination With Dipeptidyl Peptidase Iv Inhibitor
  • Polynucleotide Of Given Sequence, To Which N-Terminal Methionine Has Been Added; Treating Obesity-Related Diseases Such As Hyperlipidemia, Atherosclerosis, Diabetes, And Hypertension; Reduction And Oxidation Of Free Fatty Acids
  • Prolylcarboxypeptidase Inhibitors
  • Treatment Of Male Androgen Deficiency Symptoms Or Diseases With Sex Steroid Precursor Combined With Serm
  • Methods And Reagents For Treating Glucose Metabolic Disorders
  • Sample Scanning And Analysis System And Methods For Using The Same
  • Transmission And, Or Amplification Of Signals; Oral Or Enteric Administering, Dissolving, Absorption Of Peptide Yy; Obesity Therapy
  • Obg3 Globular Head And Uses Thereof For Decreasing Body Mass
  • Combination Therapy For The Treatment Of Diabetes And Conditions Related Thereto And For The Treatment Of Conditions Ameliorated By Increasing A Blood Glp-1 Level
  • Combination Therapy For The Treatment Of Diabetes And Conditions Related Thereto And For The Treatment Of Conditions Ameliorated By Increasing A Blood Glp-1 Level
  • Method Of Predicting Obesity Comprising Measuring Neurotensin
  • Modulates An Activity Of The Lipolysis Stimulated Receptor, Mechanisms Of Leptin Elimination; For The Treatment Of Obesity And Obesity-Related Diseases And Disorders; Antilipemic Agents
  • Prolylcarboxypeptidase Inhibitors
  • Tripeptides That Down Regulate The Activity Of Plasma Membrane Transporters Including Sodium-D-Glucose Cotransporter Sgit1
  • Use Of Flavone Compound For Prevention Or Treatment Of Obesity
  • Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same
  • Alströem Syndrome Gene, Gene Variants, Expressed Protein And Methods Of Diagnosis For Alströem Syndrome
  • Combination Of Gpr119 Agonist With A Dipeptidyl Peptidase Iv (Dpp-Iv) Inhibitor Such That Combination Provides Effect In Lowering A Blood Glucose Level Or In Increasing Blood Glp-1 Level Over That Provided By Gpr119 Agonist Or Dpp-Iv Inhibitor Alone; For Treating Or Preventing Diabetes; Synergistic
  • Gas Scanning And Analysis
  • Method, Apparatus And System For Food Intake And Physical Activity Assessment
  • Substituted Benzofused Heterocycles
  • Prolylcarboxypeptidase Inhibitors
  • Lipoprotein-Regulating Medicaments
  • G Protein-Coupled Receptor (Gpcr); Conditions Modulated By Stimulation Of Npy Y2 Receptor (Y2r) Including Bone-Related Conditions, Metabolic Disorders, Angiogenesis-Related Conditions, Ischemia-Related Conditions, Convulsive Disorders, Malabsorptive Disorders, Cancers, And Inflammatory Disorders
  • Peptides That Down Regulate The Activity Of Plasma Membrane Transporters Including Sodium-D-Glucose Cotransporter Sglt1
  • Treatment Of Male Androgen Deficiency Symptoms Or Diseases With Sex Steroid Precursor Combined With Serm
  • Methods For Manipulating Satiety
  • Lipoprotein-Regulating Medicants
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35007508

    DOI

    http://dx.doi.org/10.1038/35007508

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033953648

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10766250


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Forecasting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "St Bartholomew's & The Royal London School of Medicine, Queen Mary & Westfield College, E1 2AD, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.4868.2", 
              "name": [
                "St Bartholomew's & The Royal London School of Medicine, Queen Mary & Westfield College, E1 2AD, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kopelman", 
            "givenName": "Peter G.", 
            "id": "sg:person.01163733106.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163733106.52"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm1195-1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049565526", 
              "https://doi.org/10.1038/nm1195-1155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035410832", 
              "https://doi.org/10.1038/sj.ijo.0800492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045389973", 
              "https://doi.org/10.1038/sj.ijo.0800584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/372425a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052657184", 
              "https://doi.org/10.1038/372425a0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-04", 
        "datePublishedReg": "2000-04-01", 
        "description": "Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. Obesity is defined by a body-mass index (weight divided by square of the height) of 30 kg m\u22122 or greater, but this does not take into account the morbidity and mortality associated with more modest degrees of overweight, nor the detrimental effect of intra-abdominal fat. The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals, but an epidemic that threatens global well being.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/35007508", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6778", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "404"
          }
        ], 
        "keywords": [
          "intra-abdominal fat", 
          "coronary heart disease", 
          "body mass index", 
          "sleep-breathing disorders", 
          "obesity results", 
          "diabetes mellitus", 
          "heart disease", 
          "physical activity", 
          "cosmetic problems", 
          "obesity", 
          "global epidemic", 
          "high-energy foods", 
          "medical problems", 
          "infectious diseases", 
          "genetic susceptibility", 
          "ill health", 
          "disease", 
          "epidemic", 
          "modest degree", 
          "certain individuals", 
          "detrimental effects", 
          "mellitus", 
          "morbidity", 
          "overweight", 
          "significant contributor", 
          "world population", 
          "population", 
          "undernutrition", 
          "cancer", 
          "mortality", 
          "disorders", 
          "certain forms", 
          "fat", 
          "health", 
          "susceptibility", 
          "individuals", 
          "index", 
          "food", 
          "activity", 
          "effect", 
          "contributor", 
          "combination", 
          "degree", 
          "results", 
          "availability", 
          "form", 
          "society", 
          "problem", 
          "modern society", 
          "requirements", 
          "account"
        ], 
        "name": "Obesity as a medical problem", 
        "pagination": "635-643", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1033953648"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/35007508"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10766250"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/35007508", 
          "https://app.dimensions.ai/details/publication/pub.1033953648"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_319.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/35007508"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35007508'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35007508'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35007508'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35007508'


     

    This table displays all metadata directly associated to this object as RDF triples.

    140 TRIPLES      21 PREDICATES      84 URIs      72 LITERALS      10 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/35007508 schema:about N3449404a771d42599925e632d4cc7013
    2 N7c51443ff1f243b4860ce148a940f66e
    3 N943b2113665942828adef6b515af4496
    4 anzsrc-for:11
    5 anzsrc-for:1103
    6 schema:author N9aaf73127b934cb99333849e471a9923
    7 schema:citation sg:pub.10.1038/372425a0
    8 sg:pub.10.1038/nm1195-1155
    9 sg:pub.10.1038/sj.ijo.0800492
    10 sg:pub.10.1038/sj.ijo.0800584
    11 schema:datePublished 2000-04
    12 schema:datePublishedReg 2000-04-01
    13 schema:description Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. Obesity is defined by a body-mass index (weight divided by square of the height) of 30 kg m−2 or greater, but this does not take into account the morbidity and mortality associated with more modest degrees of overweight, nor the detrimental effect of intra-abdominal fat. The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals, but an epidemic that threatens global well being.
    14 schema:genre article
    15 schema:isAccessibleForFree false
    16 schema:isPartOf N15666de174fb49d6abc681f127e40464
    17 N4ac7a023919649a6a70e9e7d5bda44ba
    18 sg:journal.1018957
    19 schema:keywords account
    20 activity
    21 availability
    22 body mass index
    23 cancer
    24 certain forms
    25 certain individuals
    26 combination
    27 contributor
    28 coronary heart disease
    29 cosmetic problems
    30 degree
    31 detrimental effects
    32 diabetes mellitus
    33 disease
    34 disorders
    35 effect
    36 epidemic
    37 fat
    38 food
    39 form
    40 genetic susceptibility
    41 global epidemic
    42 health
    43 heart disease
    44 high-energy foods
    45 ill health
    46 index
    47 individuals
    48 infectious diseases
    49 intra-abdominal fat
    50 medical problems
    51 mellitus
    52 modern society
    53 modest degree
    54 morbidity
    55 mortality
    56 obesity
    57 obesity results
    58 overweight
    59 physical activity
    60 population
    61 problem
    62 requirements
    63 results
    64 significant contributor
    65 sleep-breathing disorders
    66 society
    67 susceptibility
    68 undernutrition
    69 world population
    70 schema:name Obesity as a medical problem
    71 schema:pagination 635-643
    72 schema:productId N527a5cf5ea1f4e90bd00fbbd229ec41f
    73 N752cd68049ec4fc6a2d1479956748759
    74 N917fd8135c1e4dda902a28cfed397d5a
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033953648
    76 https://doi.org/10.1038/35007508
    77 schema:sdDatePublished 2022-09-02T15:48
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher N8d877538eda7477daed5d480b40c2730
    80 schema:url https://doi.org/10.1038/35007508
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N15666de174fb49d6abc681f127e40464 schema:volumeNumber 404
    85 rdf:type schema:PublicationVolume
    86 N3449404a771d42599925e632d4cc7013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Forecasting
    88 rdf:type schema:DefinedTerm
    89 N4ac7a023919649a6a70e9e7d5bda44ba schema:issueNumber 6778
    90 rdf:type schema:PublicationIssue
    91 N527a5cf5ea1f4e90bd00fbbd229ec41f schema:name pubmed_id
    92 schema:value 10766250
    93 rdf:type schema:PropertyValue
    94 N752cd68049ec4fc6a2d1479956748759 schema:name dimensions_id
    95 schema:value pub.1033953648
    96 rdf:type schema:PropertyValue
    97 N7c51443ff1f243b4860ce148a940f66e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Obesity
    99 rdf:type schema:DefinedTerm
    100 N8d877538eda7477daed5d480b40c2730 schema:name Springer Nature - SN SciGraph project
    101 rdf:type schema:Organization
    102 N917fd8135c1e4dda902a28cfed397d5a schema:name doi
    103 schema:value 10.1038/35007508
    104 rdf:type schema:PropertyValue
    105 N943b2113665942828adef6b515af4496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Humans
    107 rdf:type schema:DefinedTerm
    108 N9aaf73127b934cb99333849e471a9923 rdf:first sg:person.01163733106.52
    109 rdf:rest rdf:nil
    110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    111 schema:name Medical and Health Sciences
    112 rdf:type schema:DefinedTerm
    113 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    114 schema:name Clinical Sciences
    115 rdf:type schema:DefinedTerm
    116 sg:journal.1018957 schema:issn 0028-0836
    117 1476-4687
    118 schema:name Nature
    119 schema:publisher Springer Nature
    120 rdf:type schema:Periodical
    121 sg:person.01163733106.52 schema:affiliation grid-institutes:grid.4868.2
    122 schema:familyName Kopelman
    123 schema:givenName Peter G.
    124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163733106.52
    125 rdf:type schema:Person
    126 sg:pub.10.1038/372425a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052657184
    127 https://doi.org/10.1038/372425a0
    128 rdf:type schema:CreativeWork
    129 sg:pub.10.1038/nm1195-1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049565526
    130 https://doi.org/10.1038/nm1195-1155
    131 rdf:type schema:CreativeWork
    132 sg:pub.10.1038/sj.ijo.0800492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035410832
    133 https://doi.org/10.1038/sj.ijo.0800492
    134 rdf:type schema:CreativeWork
    135 sg:pub.10.1038/sj.ijo.0800584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045389973
    136 https://doi.org/10.1038/sj.ijo.0800584
    137 rdf:type schema:CreativeWork
    138 grid-institutes:grid.4868.2 schema:alternateName St Bartholomew's & The Royal London School of Medicine, Queen Mary & Westfield College, E1 2AD, London, UK
    139 schema:name St Bartholomew's & The Royal London School of Medicine, Queen Mary & Westfield College, E1 2AD, London, UK
    140 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...