Functional hydrogel structures for autonomous flow control inside microfluidic channels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

David J. Beebe, Jeffrey S. Moore, Joseph M. Bauer, Qing Yu, Robin H. Liu, Chelladurai Devadoss, Byung-Ho Jo

ABSTRACT

Hydrogels have been developed to respond to a wide variety of stimuli, but their use in macroscopic systems has been hindered by slow response times (diffusion being the rate-limiting factor governing the swelling process). However, there are many natural examples of chemically driven actuation that rely on short diffusion paths to produce a rapid response. It is therefore expected that scaling down hydrogel objects to the micrometre scale should greatly improve response times. At these scales, stimuli-responsive hydrogels could enhance the capabilities of microfluidic systems by allowing self-regulated flow control. Here we report the fabrication of active hydrogel components inside microchannels via direct photopatterning of a liquid phase. Our approach greatly simplifies system construction and assembly as the functional components are fabricated in situ, and the stimuli-responsive hydrogel components perform both sensing and actuation functions. We demonstrate significantly improved response times (less than 10 seconds) in hydrogel valves capable of autonomous control of local flow. More... »

PAGES

588

Journal

TITLE

Nature

ISSUE

6778

VOLUME

404

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  • Identifiers

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    DOI

    http://dx.doi.org/10.1038/35007047

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10766238


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