Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-03

AUTHORS

Yi-Ping Hsueh, Ting-Fang Wang, Fu-Chia Yang, Morgan Sheng

ABSTRACT

Membrane-associated guanylate kinases (MAGUKs) contain multiple protein-binding domains that allow them to assemble specific multiprotein complexes in particular regions of the cell1,2. CASK/LIN-2, a MAGUK required for EGF receptor localization and signalling in Caenorhabditis elegans, contains a calmodulin-dependent protein kinase-like domain followed by PDZ, SH3 and guanylate kinase-like domains3,4,5. In adult rat brain, CASK is concentrated at neuronal synapses and binds to the cell-surface proteins neurexin and syndecan6,7,8 and the cytoplasmic proteins Mint/LIN-10 and Veli/LIN-7 (refs 4, 9, 10). Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-box transcription factor that is involved in forebrain development11,12. CASK enters the nucleus and binds to a specific DNA sequence (the T-element) in a complex with Tbr-1. CASK acts as a coactivator of Tbr-1 to induce transcription of T-element containing genes, including reelin, a gene that is essential for cerebrocortical development. Our findings show that a MAGUK which is usually associated with cell junctions has a transcription regulation function. More... »

PAGES

298-302

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35005118

DOI

http://dx.doi.org/10.1038/35005118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003313867

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10749215


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