Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-02

AUTHORS

B Prakash, G J Praefcke, L Renault, A Wittinghofer, C Herrmann

ABSTRACT

Interferon-gamma is an immunomodulatory substance that induces the expression of many genes to orchestrate a cellular response and establish the antiviral state of the cell. Among the most abundant antiviral proteins induced by interferon-gamma are guanylate-binding proteins such as GBP1 and GBP2. These are large GTP-binding proteins of relative molecular mass 67,000 with a high-turnover GTPase activity and an antiviral effect. Here we have determined the crystal structure of full-length human GBP1 to 1.8 A resolution. The amino-terminal 278 residues constitute a modified G domain with a number of insertions compared to the canonical Ras structure, and the carboxy-terminal part is an extended helical domain with unique features. From the structure and biochemical experiments reported here, GBP1 appears to belong to the group of large GTP-binding proteins that includes Mx and dynamin, the common property of which is the ability to undergo oligomerization with a high concentration-dependent GTPase activity. More... »

PAGES

567

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35000617

DOI

http://dx.doi.org/10.1038/35000617

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038808720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10676968


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