Evidence for stabilizing selection in a eukaryotic enhancer element View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-02

AUTHORS

Michael Z. Ludwig, Casey Bergman, Nipam H. Patel, Martin Kreitman

ABSTRACT

Eukaryotic gene expression is mediated by compact cis-regulatory modules, or enhancers, which are bound by specific sets of transcription factors1. The combinatorial interaction of these bound transcription factors determines time- and tissue-specific gene activation or repression. The even-skipped stripe 2 element controls the expression of the second transverse stripe of even-skipped messenger RNA in Drosophila melanogaster embryos, and is one of the best characterized eukaryotic enhancers2,3,4. Although even-skipped stripe 2 expression is strongly conserved in Drosophila, the stripe 2 element itself has undergone considerable evolutionary change in its binding-site sequences and the spacing between them. We have investigated this apparent contradiction, and here we show that two chimaeric enhancers, constructed by swapping the 5′ and 3′ halves of the native stripe 2 elements of two species, no longer drive expression of a reporter gene in the wild-type pattern. Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. More... »

PAGES

564-567

References to SciGraph publications

  • 1984-11. Molecular evolution inDrosophila and the higher diptera in JOURNAL OF MOLECULAR EVOLUTION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35000615

    DOI

    http://dx.doi.org/10.1038/35000615

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020681013

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10676967


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    213 grid-institutes:grid.413575.1 schema:alternateName Department of Organismal Biology and Anatomy, and Howard Hughes Medical Institute, MC1028, N-101, 5841 South Maryland Avenue, 60637, Chicago, Illinois, USA
    214 schema:name Department of Organismal Biology and Anatomy, and Howard Hughes Medical Institute, MC1028, N-101, 5841 South Maryland Avenue, 60637, Chicago, Illinois, USA
    215 rdf:type schema:Organization
     




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