Ontology type: schema:ScholarlyArticle
2000-02
AUTHORSAsh A. Alizadeh, Michael B. Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer C. Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I. Powell, Liming Yang, Gerald E. Marti, Troy Moore, James Hudson, Lisheng Lu, David B. Lewis, Robert Tibshirani, Gavin Sherlock, Wing C. Chan, Timothy C. Greiner, Dennis D. Weisenburger, James O. Armitage, Roger Warnke, Ronald Levy, Wyndham Wilson, Michael R. Grever, John C. Byrd, David Botstein, Patrick O. Brown, Louis M. Staudt
ABSTRACTDiffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells (‘germinal centre B-like DLBCL’); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells (‘activated B-like DLBCL’). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer. More... »
PAGES503-511
http://scigraph.springernature.com/pub.10.1038/35000501
DOIhttp://dx.doi.org/10.1038/35000501
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1010898206
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10676951
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Profiling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Lymphocytic, Chronic, B-Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma, B-Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma, Large B-Cell, Diffuse",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligonucleotide Array Sequence Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Cells, Cultured",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Departments of Biochemistry",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Departments of Biochemistry"
],
"type": "Organization"
},
"familyName": "Alizadeh",
"givenName": "Ash A.",
"id": "sg:person.01350734042.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350734042.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA",
"id": "http://www.grid.ac/institutes/grid.47840.3f",
"name": [
"Genetics",
"Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA"
],
"type": "Organization"
},
"familyName": "Eisen",
"givenName": "Michael B.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Davis",
"givenName": "R. Eric",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Ma",
"givenName": "Chi",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medicine",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Medicine"
],
"type": "Organization"
},
"familyName": "Lossos",
"givenName": "Izidore S.",
"id": "sg:person.01156610632.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156610632.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Rosenwald",
"givenName": "Andreas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Biochemistry",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Departments of Biochemistry"
],
"type": "Organization"
},
"familyName": "Boldrick",
"givenName": "Jennifer C.",
"id": "sg:person.01147337213.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147337213.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Sabet",
"givenName": "Hajeer",
"id": "sg:person.012635177675.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012635177675.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Tran",
"givenName": "Truc",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Yu",
"givenName": "Xin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.410422.1",
"name": [
"Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Powell",
"givenName": "John I.",
"id": "sg:person.01044224567.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044224567.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.410422.1",
"name": [
"Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Liming",
"type": "Person"
},
{
"affiliation": {
"alternateName": "CBER, FDA, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.290496.0",
"name": [
"CBER, FDA, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Marti",
"givenName": "Gerald E.",
"id": "sg:person.01352650472.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352650472.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Genetics, 35801, Huntsville, Alabama, USA",
"id": "http://www.grid.ac/institutes/grid.418190.5",
"name": [
"Research Genetics, 35801, Huntsville, Alabama, USA"
],
"type": "Organization"
},
"familyName": "Moore",
"givenName": "Troy",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Genetics, 35801, Huntsville, Alabama, USA",
"id": "http://www.grid.ac/institutes/grid.418190.5",
"name": [
"Research Genetics, 35801, Huntsville, Alabama, USA"
],
"type": "Organization"
},
"familyName": "Hudson",
"givenName": "James",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Pediatrics",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Pediatrics"
],
"type": "Organization"
},
"familyName": "Lu",
"givenName": "Lisheng",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Pediatrics",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Pediatrics"
],
"type": "Organization"
},
"familyName": "Lewis",
"givenName": "David B.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Health Research & Policy and Statistics",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Health Research & Policy and Statistics"
],
"type": "Organization"
},
"familyName": "Tibshirani",
"givenName": "Robert",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA",
"id": "http://www.grid.ac/institutes/grid.47840.3f",
"name": [
"Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA"
],
"type": "Organization"
},
"familyName": "Sherlock",
"givenName": "Gavin",
"id": "sg:person.0617263730.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617263730.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Pathology and Microbiology",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Departments of Pathology and Microbiology"
],
"type": "Organization"
},
"familyName": "Chan",
"givenName": "Wing C.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Pathology and Microbiology",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Departments of Pathology and Microbiology"
],
"type": "Organization"
},
"familyName": "Greiner",
"givenName": "Timothy C.",
"id": "sg:person.015703563537.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015703563537.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departments of Pathology and Microbiology",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Departments of Pathology and Microbiology"
],
"type": "Organization"
},
"familyName": "Weisenburger",
"givenName": "Dennis D.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Internal Medicine, University of Nebraska Medical Center, 68198, Omaha, Nebraska, USA",
"id": "http://www.grid.ac/institutes/grid.266813.8",
"name": [
"Internal Medicine, University of Nebraska Medical Center, 68198, Omaha, Nebraska, USA"
],
"type": "Organization"
},
"familyName": "Armitage",
"givenName": "James O.",
"id": "sg:person.01306034711.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306034711.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Pathology",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Pathology"
],
"type": "Organization"
},
"familyName": "Warnke",
"givenName": "Roger",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Medicine",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Medicine"
],
"type": "Organization"
},
"familyName": "Levy",
"givenName": "Ronald",
"id": "sg:person.01053313200.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053313200.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Medicine Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Medicine Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Wilson",
"givenName": "Wyndham",
"id": "sg:person.07764030507.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07764030507.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins Oncology Center, Johns Hopkins School of Medicine, 21287, Baltimore, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.21107.35",
"name": [
"Johns Hopkins Oncology Center, Johns Hopkins School of Medicine, 21287, Baltimore, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Grever",
"givenName": "Michael R.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Walter Reed Army Medical Center, 20307, Washington, DC, USA",
"id": "http://www.grid.ac/institutes/grid.414467.4",
"name": [
"Walter Reed Army Medical Center, 20307, Washington, DC, USA"
],
"type": "Organization"
},
"familyName": "Byrd",
"givenName": "John C.",
"id": "sg:person.01115130607.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115130607.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA",
"id": "http://www.grid.ac/institutes/grid.47840.3f",
"name": [
"Life Sciences Division, Lawrence Orlando Berkeley National Labs and Department of Molecular and Cellular Biology, University of California, 94720, Berkeley, California, USA"
],
"type": "Organization"
},
"familyName": "Botstein",
"givenName": "David",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Howard Hughes Medical Institute, Stanford University School of Medicine, 94305, Stanford, California, USA",
"id": "http://www.grid.ac/institutes/grid.168010.e",
"name": [
"Departments of Biochemistry",
"Howard Hughes Medical Institute, Stanford University School of Medicine, 94305, Stanford, California, USA"
],
"type": "Organization"
},
"familyName": "Brown",
"givenName": "Patrick O.",
"id": "sg:person.014304415612.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014304415612.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA",
"id": "http://www.grid.ac/institutes/grid.48336.3a",
"name": [
"Division of Clinical Sciences, Metabolism Branch, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA"
],
"type": "Organization"
},
"familyName": "Staudt",
"givenName": "Louis M.",
"id": "sg:person.0750405002.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750405002.26"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ng1296-457",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010987019",
"https://doi.org/10.1038/ng1296-457"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2401487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017462984",
"https://doi.org/10.1038/sj.leu.2401487"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1097-226",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001550579",
"https://doi.org/10.1038/ng1097-226"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1023293621057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035311070",
"https://doi.org/10.1023/a:1023293621057"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0697-161",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047492526",
"https://doi.org/10.1038/ng0697-161"
],
"type": "CreativeWork"
}
],
"datePublished": "2000-02",
"datePublishedReg": "2000-02-01",
"description": "Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells (\u2018germinal centre B-like DLBCL\u2019); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells (\u2018activated B-like DLBCL\u2019). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer.",
"genre": "article",
"id": "sg:pub.10.1038/35000501",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2724456",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2715036",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6769",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "403"
}
],
"keywords": [
"diffuse large B-cell lymphoma",
"large B-cell lymphoma",
"B-cell lymphoma",
"like diffuse large B-cell lymphoma",
"B cells",
"peripheral blood B cells",
"better overall survival",
"blood B cells",
"germinal center B cells",
"B-cell malignancies",
"tumor proliferation rate",
"germinal center B",
"B cell differentiation",
"overall survival",
"Hodgkin's lymphoma",
"common subtype",
"current therapies",
"DLBCL patients",
"gene expression",
"host response",
"lymphoma",
"natural history",
"tumors",
"patients",
"molecular classification",
"gene expression profiling",
"center B",
"proliferation rate",
"significant subtypes",
"molecular heterogeneity",
"subtypes",
"differentiation state",
"survival",
"expression profiling",
"gene expression patterns",
"expression",
"expression patterns",
"cells",
"malignancy",
"therapy",
"cancer",
"disease",
"DNA microarrays",
"different stages",
"distinct forms",
"genes",
"activation",
"distinct types",
"succumb",
"microarray",
"response",
"differentiation",
"types",
"history",
"profiling",
"rate",
"heterogeneity",
"stage",
"patterns",
"classification",
"variability",
"systematic characterization",
"second type",
"basis",
"form",
"diversity",
"characterization",
"variation",
"state"
],
"name": "Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling",
"pagination": "503-511",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1010898206"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/35000501"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10676951"
]
}
],
"sameAs": [
"https://doi.org/10.1038/35000501",
"https://app.dimensions.ai/details/publication/pub.1010898206"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:46",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_324.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/35000501"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35000501'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35000501'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35000501'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35000501'
This table displays all metadata directly associated to this object as RDF triples.
437 TRIPLES
22 PREDICATES
113 URIs
98 LITERALS
17 BLANK NODES