Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-02

AUTHORS

Ash A. Alizadeh, Michael B. Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer C. Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I. Powell, Liming Yang, Gerald E. Marti, Troy Moore, James Hudson, Lisheng Lu, David B. Lewis, Robert Tibshirani, Gavin Sherlock, C. Chan, Timothy C. Greiner, Dennis D. Weisenburger, James O. Armitage, Roger Warnke, Ronald Levy, Wyndham Wilson, Michael R. Grever, John C. Byrd, David Botstein, Patrick O. Brown, Louis M. Staudt

ABSTRACT

Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells ('activated B-like DLBCL'). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer. More... »

PAGES

503

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6769

VOLUME

403

Clinical Trials linked to this publication

Related Patents

  • Method For Differentiating Between The Non-Infectious And Infectious Causes Of Multiple Organ Failure
  • Polypeptides And Antibodies Derived From Chronic Lymphocytic Leukemia Cells And Uses Thereof
  • Method For Differentiating Between The Non-Infectious And Infectious Causes Of Multiple Organ Failure
  • Methods For Feature Selection In A Learning Machine
  • Method Of Diagnosis Of Cancer Based On Gene Expression Profiles In Cells
  • Module-Level Analysis Of Peripheral Blood Leukocyte Transcriptional Profiles
  • Identification Of Novel Targets For Radio Sensitization Using A Genomic-Based Radiation Sensitivity Classifier
  • Genes Associated With Progression And Response In Chronic Myeloid Leukemia And Uses Thereof
  • Biomarkers And Methods For Determining Sensitivity To Epidermal Growth Factor Receptor Modulators
  • Neoepitope Detection Of Disease Using Protein Arrays
  • Methods And Compositions For Diagnosing And Monitoring Transplant Rejection
  • Selective Inhibition Of Malt1 Protease By Phenothiazine Derivatives
  • Crystal Structure Of Human Mitoneet Protein
  • Diagnostic Tests Using Gene Expression Ratios
  • Methods For Treating Chronic Lymphocytic Leukemia
  • Lymphoma Associated Molecules And Uses Therefor
  • Murine Stem Cells And Applications Thereof
  • System For Identifying Patterns In Biological Data Using A Distributed Network
  • Collapsin Response Mediator Protein-1
  • Methods For Feature Selection In A Learning Machine
  • Method And Device For The In Vitro Analysis Of Mrna Of Genes Involved In Haematological Neoplasias
  • Methods For Determining Sensitivity To Microtubule-Stabilizing Agents Comprising Ixabepilone By Measuring The Level Of Estrogen Receptor 1
  • Methods Of Identifying Biological Patterns Using Multiple Data Sets
  • Chronic Lymphocytic Leukemia Cell Line
  • Classification Of Breast Cancer Patients Using A Combination Of Clinical Criteria And Informative Genesets
  • Methods For Identifying, Diagnosing, And Predicting Survival Of Lymphomas
  • Antibodies To Ox-2/Cd200 And Uses Thereof
  • Method For Feature Selection And For Evaluating Features Identified As Significant For Classifying Data
  • Methods And Compositions For Diagnosing And Monitoring Auto Immune And Chronic Inflammatory Diseases
  • Profiling Tumor Specific Markers For The Diagnosis And Treatment Of Neoplastic Disease
  • Reagents And Methods For Use In Cancer Diagnosis, Classification And Therapy
  • Method For In Vitro Detection Of Severe Septicaemia
  • Methods For Identifying, Diagnosing, And Predicting Survival Of Lymphomas
  • Diagnosing And Grading Gliomas Using A Proteomics Approach
  • Survival Predictor For Diffuse Large B Cell Lymphoma
  • Classifiers Of Nf-Κb Pathway Activation, Devices, And Methods Of Use Thereof
  • Treatment Of Diffuse Large B-Cell Lymphoma And Of Non-Hodgkin's Lymphome Using Lenalidomide
  • Polypeptides And Antibodies Derived From Chronic Lymphocytic Leukemia Cells And Uses Thereof
  • Classification Of Patients Having Diffuse Large B-Cell Lymphoma Based Upon Gene Expression
  • Simulating Microarrays Using A Parameterized Model
  • Significance Analysis Of Microarrays
  • Diagnostic Tests Using Gene Expression Ratios
  • Method For The Identification Of Sepsis
  • Pre-Processed Feature Ranking For A Support Vector Machine
  • Methods For Predicting Chemosensitivity Or Chemoresistance
  • Methods For Subtyping Diffuse B-Cell Lymphoma (Dlbcl)
  • Methods For Identifying Heterozygous Carriers Of Autosomal Recessive Diseases
  • Method For Enhancing Knowledge Discovered From Biological Data Using A Learning Machine
  • Small Molecule Inhibitors Of Malt1
  • Method For Selecting A Treatment For Non-Small Cell Lung Cancer Using Gene Expression Profiles
  • Methods For Treating Hematopoietic Malignancies
  • Lymphoma Prognostic Methods And Kits
  • Methods And Compositions For Diagnosing Or Monitoring Autoimmune And Chronic Inflammatory Diseases
  • Reagents And Methods For Use In Cancer Diagnosis, Classification And Therapy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35000501

    DOI

    http://dx.doi.org/10.1038/35000501

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010898206

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10676951


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "B-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukemia, Lymphocytic, Chronic, B-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, B-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphoma, Large B-Cell, Diffuse", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Cells, Cultured", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "*Departments of Biochemistry,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alizadeh", 
            "givenName": "Ash A.", 
            "id": "sg:person.01350734042.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350734042.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u2016Genetics,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eisen", 
            "givenName": "Michael B.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davis", 
            "givenName": "R. Eric", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ma", 
            "givenName": "Chi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00b6Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lossos", 
            "givenName": "Izidore S.", 
            "id": "sg:person.01156610632.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156610632.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenwald", 
            "givenName": "Andreas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "*Departments of Biochemistry,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boldrick", 
            "givenName": "Jennifer C.", 
            "id": "sg:person.01147337213.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147337213.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sabet", 
            "givenName": "Hajeer", 
            "id": "sg:person.012635177675.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012635177675.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tran", 
            "givenName": "Truc", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Xin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "#Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Powell", 
            "givenName": "John I.", 
            "id": "sg:person.01044224567.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044224567.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "#Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Liming", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "United States Food and Drug Administration", 
              "id": "https://www.grid.ac/institutes/grid.417587.8", 
              "name": [
                "\u00a7CBER, FDA, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marti", 
            "givenName": "Gerald E.", 
            "id": "sg:person.01352650472.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352650472.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Thermo Fisher Scientific (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418190.5", 
              "name": [
                "\u2606Research Genetics, Huntsville , Alabama 35801, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moore", 
            "givenName": "Troy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Thermo Fisher Scientific (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418190.5", 
              "name": [
                "\u2606Research Genetics, Huntsville , Alabama 35801, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hudson", 
            "givenName": "James", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "**Pediatrics and"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Lisheng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "**Pediatrics and"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lewis", 
            "givenName": "David B.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u2020\u2020Health Research & Policy and Statistics, and"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tibshirani", 
            "givenName": "Robert", 
            "type": "Person"
          }, 
          {
            "familyName": "Sherlock", 
            "givenName": "Gavin", 
            "id": "sg:person.0617263730.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617263730.50"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Chan", 
            "givenName": "C.", 
            "type": "Person"
          }, 
          {
            "familyName": "Greiner", 
            "givenName": "Timothy C.", 
            "type": "Person"
          }, 
          {
            "familyName": "Weisenburger", 
            "givenName": "Dennis D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nebraska Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.266813.8", 
              "name": [
                "\u2021\u2021Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Armitage", 
            "givenName": "James O.", 
            "id": "sg:person.01306034711.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306034711.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00b6\u00b6Pathology,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warnke", 
            "givenName": "Roger", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00b6Medicine,"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levy", 
            "givenName": "Ronald", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "##Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Wyndham", 
            "id": "sg:person.07764030507.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07764030507.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "\u00a7\u00a7Johns Hopkins Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grever", 
            "givenName": "Michael R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Walter Reed National Military Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.414467.4", 
              "name": [
                "\u2606\u2606Walter Reed Army Medical Center , Washington, DC 20307, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Byrd", 
            "givenName": "John C.", 
            "type": "Person"
          }, 
          {
            "familyName": "Botstein", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "*Departments of Biochemistry,", 
                "Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "Patrick O.", 
            "id": "sg:person.014304415612.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014304415612.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "\u222bMetabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Staudt", 
            "givenName": "Louis M.", 
            "id": "sg:person.0750405002.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750405002.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1172/jci115205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001362998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1097-226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001550579", 
              "https://doi.org/10.1038/ng1097-226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.16.9212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002392246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.275.5299.540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009053054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1296-457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010987019", 
              "https://doi.org/10.1038/ng1296-457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199309303291402", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013554742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.276.5312.589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014082032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199606)179:2<145::aid-path565>3.0.co;2-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014370189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9896(199606)179:2<145::aid-path565>3.0.co;2-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014370189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017462984", 
              "https://doi.org/10.1038/sj.leu.2401487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017462984", 
              "https://doi.org/10.1038/sj.leu.2401487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.7.1025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018218908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.17.2651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019160542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.25.14863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020882317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08830189909088490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022411448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/23.12.2127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022776974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.9.1679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023876130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.7.1033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025288591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/91.20.1758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031623677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.12.6745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033514193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1023293621057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035311070", 
              "https://doi.org/10.1023/a:1023293621057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0378-1119(99)00035-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039207160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(99)03014-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040259960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.15.6770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042706782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5439.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042995627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199304083281404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043239598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0697-161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047492526", 
              "https://doi.org/10.1038/ng0697-161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.3.439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049167524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(98)80223-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049365667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.9.1691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051868501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1998.tb01447.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053542093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.9.1547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058438634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.1999.64.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060415749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.270.5235.467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062551475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/095952873201700106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063895540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-127-3-199708010-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073701584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079660171", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082445528", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082613112", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082636329", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082636330", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082877384", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082895244", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1996.14.7.2131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082907384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083111437", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083313190", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083335823", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083350334", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-02", 
        "datePublishedReg": "2000-02-01", 
        "description": "Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells ('activated B-like DLBCL'). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/35000501", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2724456", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2715036", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6769", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "403"
          }
        ], 
        "name": "Distinct types of diffuse large B-cell lymphoma identified by gene expression\nprofiling", 
        "pagination": "503", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "33ec0e75d960fb90c00989ace916f5216befd9a81cd7153fb8157aaa112772b1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10676951"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/35000501"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010898206"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/35000501", 
          "https://app.dimensions.ai/details/publication/pub.1010898206"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/35000501"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35000501'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35000501'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35000501'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35000501'


     

    This table displays all metadata directly associated to this object as RDF triples.

    472 TRIPLES      21 PREDICATES      85 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/35000501 schema:about N3f34a647809946bc89457ba10c3aefac
    2 N587a8762a97c4731b6ce6acc9eee756f
    3 N7a8a248155e847208367109a1099e848
    4 Na4933a27fa2d4640b82b260ec0d87493
    5 Nc6d8395c31fd4916b47b362b5895403c
    6 Nd47ccf5a0de54c75b3f3b66a733a17b9
    7 Nd5c8052edff24d93ab75c40e02726acb
    8 Ndbf8bd1c387245a586f00c66b699e317
    9 Ne898ab9d86b14c3f98641440f3e03966
    10 Nf3dae9b107384e99abec76fef2527450
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author N4852bfe6982d4fea8990148ee6a7d5b9
    14 schema:citation sg:pub.10.1023/a:1023293621057
    15 sg:pub.10.1038/ng0697-161
    16 sg:pub.10.1038/ng1097-226
    17 sg:pub.10.1038/ng1296-457
    18 sg:pub.10.1038/sj.leu.2401487
    19 https://app.dimensions.ai/details/publication/pub.1079660171
    20 https://app.dimensions.ai/details/publication/pub.1082445528
    21 https://app.dimensions.ai/details/publication/pub.1082613112
    22 https://app.dimensions.ai/details/publication/pub.1082636329
    23 https://app.dimensions.ai/details/publication/pub.1082636330
    24 https://app.dimensions.ai/details/publication/pub.1082877384
    25 https://app.dimensions.ai/details/publication/pub.1082895244
    26 https://app.dimensions.ai/details/publication/pub.1083111437
    27 https://app.dimensions.ai/details/publication/pub.1083313190
    28 https://app.dimensions.ai/details/publication/pub.1083335823
    29 https://app.dimensions.ai/details/publication/pub.1083350334
    30 https://doi.org/10.1002/(sici)1096-9896(199606)179:2<145::aid-path565>3.0.co;2-1
    31 https://doi.org/10.1016/s0076-6879(99)03014-1
    32 https://doi.org/10.1016/s0378-1119(99)00035-9
    33 https://doi.org/10.1016/s0952-7915(98)80223-9
    34 https://doi.org/10.1056/nejm199304083281404
    35 https://doi.org/10.1056/nejm199309303291402
    36 https://doi.org/10.1073/pnas.89.15.6770
    37 https://doi.org/10.1073/pnas.95.25.14863
    38 https://doi.org/10.1073/pnas.96.12.6745
    39 https://doi.org/10.1073/pnas.96.16.9212
    40 https://doi.org/10.1084/jem.186.3.439
    41 https://doi.org/10.1084/jem.186.9.1547
    42 https://doi.org/10.1084/jem.188.9.1679
    43 https://doi.org/10.1084/jem.188.9.1691
    44 https://doi.org/10.1084/jem.190.7.1025
    45 https://doi.org/10.1084/jem.190.7.1033
    46 https://doi.org/10.1093/jnci/91.20.1758
    47 https://doi.org/10.1093/nar/23.12.2127
    48 https://doi.org/10.1101/gad.12.17.2651
    49 https://doi.org/10.1101/sqb.1999.64.71
    50 https://doi.org/10.1111/j.1600-065x.1998.tb01447.x
    51 https://doi.org/10.1126/science.270.5235.467
    52 https://doi.org/10.1126/science.275.5299.540
    53 https://doi.org/10.1126/science.276.5312.589
    54 https://doi.org/10.1126/science.286.5439.531
    55 https://doi.org/10.1172/jci115205
    56 https://doi.org/10.1177/095952873201700106
    57 https://doi.org/10.1200/jco.1996.14.7.2131
    58 https://doi.org/10.3109/08830189909088490
    59 https://doi.org/10.7326/0003-4819-127-3-199708010-00002
    60 schema:datePublished 2000-02
    61 schema:datePublishedReg 2000-02-01
    62 schema:description Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history reflects unrecognized molecular heterogeneity in the tumours. Using DNA microarrays, we have conducted a systematic characterization of gene expression in B-cell malignancies. Here we show that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. We identified two molecularly distinct forms of DLBCL which had gene expression patterns indicative of different stages of B-cell differentiation. One type expressed genes characteristic of germinal centre B cells ('germinal centre B-like DLBCL'); the second type expressed genes normally induced during in vitro activation of peripheral blood B cells ('activated B-like DLBCL'). Patients with germinal centre B-like DLBCL had a significantly better overall survival than those with activated B-like DLBCL. The molecular classification of tumours on the basis of gene expression can thus identify previously undetected and clinically significant subtypes of cancer.
    63 schema:genre research_article
    64 schema:inLanguage en
    65 schema:isAccessibleForFree false
    66 schema:isPartOf N4e273c818f3542f1b1dd508722b23a29
    67 Ne953d79bc2d64e0f9d7a37ec30743095
    68 sg:journal.1018957
    69 schema:name Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    70 schema:pagination 503
    71 schema:productId N204fa7a611a740948a01b72d3ea92123
    72 N38bdd365e95146179a9cd8f06bb99b52
    73 N5c5b72326afa4e13913213fbe27fdb19
    74 Nc6701f5495a14403b848bb59e45de8d8
    75 Nceaeea6d1da74abc8c2ea2ee28b6e350
    76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898206
    77 https://doi.org/10.1038/35000501
    78 schema:sdDatePublished 2019-04-11T12:23
    79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    80 schema:sdPublisher Na3afe44d90cd4f348845b4315e5656c1
    81 schema:url https://www.nature.com/articles/35000501
    82 sgo:license sg:explorer/license/
    83 sgo:sdDataset articles
    84 rdf:type schema:ScholarlyArticle
    85 N0494a90c05324743b8578366db27cef3 rdf:first Nccd5be65eee3494cb563d38cc3b241da
    86 rdf:rest Ncdf65a990d5849ac81cbe7cccc254d57
    87 N068709681d884fcaa82e40fbaee64bc4 rdf:first N50ac601911e6484f9220ba96de17e32f
    88 rdf:rest Nc1047ec0c5204c7e9be47e3be6d3d669
    89 N0a0000d07ae444fcb236198cc533ff28 schema:familyName Greiner
    90 schema:givenName Timothy C.
    91 rdf:type schema:Person
    92 N0b99a8ef1419441da23628d5b78784a8 rdf:first N1a79ba4a32e94fea9382fb10629d92e6
    93 rdf:rest N698a982248b8409bbe169d0dbc663fa0
    94 N0bf71260115b47eda7feba5e1baf7a63 schema:affiliation N6ff44093d05944c8af06409ced8763d2
    95 schema:familyName Tibshirani
    96 schema:givenName Robert
    97 rdf:type schema:Person
    98 N0e4652d165d14d16b93e738f6455c8fd schema:name ¶Medicine,
    99 rdf:type schema:Organization
    100 N0e68100d39cb4a0bacf019304ef5b218 schema:name ¶Medicine,
    101 rdf:type schema:Organization
    102 N12558b5d39b24bd182297ede5971bd7e rdf:first Nb7133d941e6642f08e3c8cc21bd868c9
    103 rdf:rest N37106dc3cfdd49e58f8d9171529aeaa5
    104 N17132c1cd12f475b82a091ba958319d7 schema:name **Pediatrics and
    105 rdf:type schema:Organization
    106 N1a79ba4a32e94fea9382fb10629d92e6 schema:familyName Weisenburger
    107 schema:givenName Dennis D.
    108 rdf:type schema:Person
    109 N1efa572323be445ba24b402d99f87337 rdf:first N5286b989563049e2bbecdab7e2273876
    110 rdf:rest Nd0b081898c9d41ffa2b81951881f0568
    111 N204fa7a611a740948a01b72d3ea92123 schema:name nlm_unique_id
    112 schema:value 0410462
    113 rdf:type schema:PropertyValue
    114 N24e1d89dacad4c88bf77b5a5a8d70631 rdf:first N967f9744b1c14b3ea8f7d528d971ce07
    115 rdf:rest N6a9e59ac785e462b9e57029912994577
    116 N26706ea310e84423b7f6b6bb5bbcff9d schema:affiliation https://www.grid.ac/institutes/grid.418190.5
    117 schema:familyName Moore
    118 schema:givenName Troy
    119 rdf:type schema:Person
    120 N37106dc3cfdd49e58f8d9171529aeaa5 rdf:first Ned70f48c65ea48569e791aad3bc411e4
    121 rdf:rest N4b40a8f8190740368b92853ea3fdd988
    122 N38bdd365e95146179a9cd8f06bb99b52 schema:name readcube_id
    123 schema:value 33ec0e75d960fb90c00989ace916f5216befd9a81cd7153fb8157aaa112772b1
    124 rdf:type schema:PropertyValue
    125 N3b9a4e1ce2e04492b1c19fb8d363e22e rdf:first sg:person.012635177675.42
    126 rdf:rest Ndcd68cf9267c4930a45884e556933d07
    127 N3d7c8a75ef49400c864f721158d9fc2c schema:name **Pediatrics and
    128 rdf:type schema:Organization
    129 N3f34a647809946bc89457ba10c3aefac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Lymphoma, B-Cell
    131 rdf:type schema:DefinedTerm
    132 N4852bfe6982d4fea8990148ee6a7d5b9 rdf:first sg:person.01350734042.58
    133 rdf:rest N12558b5d39b24bd182297ede5971bd7e
    134 N4b02cfa3bc2741f491a63609efc8fd30 rdf:first N0a0000d07ae444fcb236198cc533ff28
    135 rdf:rest N0b99a8ef1419441da23628d5b78784a8
    136 N4b40a8f8190740368b92853ea3fdd988 rdf:first N5bee7aec7728409cb0998f26e9efaef0
    137 rdf:rest N7a73771c2d314df288eb9861027c4a45
    138 N4db48122c8e04b1db6e05a337ee9a416 schema:name *Departments of Biochemistry,
    139 rdf:type schema:Organization
    140 N4e273c818f3542f1b1dd508722b23a29 schema:volumeNumber 403
    141 rdf:type schema:PublicationVolume
    142 N4e56a15cb0734524a23cdda840a267b8 schema:familyName Chan
    143 schema:givenName C.
    144 rdf:type schema:Person
    145 N4e9f2e27912543048ee4c0ea4ef3e52b schema:affiliation N8b8085dedf65446e8107349a67039f89
    146 schema:familyName Warnke
    147 schema:givenName Roger
    148 rdf:type schema:Person
    149 N50ac601911e6484f9220ba96de17e32f schema:affiliation Nc8a249a3cf464939a032d28db6e7a534
    150 schema:familyName Yang
    151 schema:givenName Liming
    152 rdf:type schema:Person
    153 N5286b989563049e2bbecdab7e2273876 schema:affiliation N3d7c8a75ef49400c864f721158d9fc2c
    154 schema:familyName Lewis
    155 schema:givenName David B.
    156 rdf:type schema:Person
    157 N587a8762a97c4731b6ce6acc9eee756f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Gene Expression Profiling
    159 rdf:type schema:DefinedTerm
    160 N5bee7aec7728409cb0998f26e9efaef0 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    161 schema:familyName Ma
    162 schema:givenName Chi
    163 rdf:type schema:Person
    164 N5c5b72326afa4e13913213fbe27fdb19 schema:name pubmed_id
    165 schema:value 10676951
    166 rdf:type schema:PropertyValue
    167 N6209d11b53da479ea006a6f417c783b8 schema:affiliation https://www.grid.ac/institutes/grid.414467.4
    168 schema:familyName Byrd
    169 schema:givenName John C.
    170 rdf:type schema:Person
    171 N63e1238f677149108adc978d15dccd3b rdf:first N4e56a15cb0734524a23cdda840a267b8
    172 rdf:rest N4b02cfa3bc2741f491a63609efc8fd30
    173 N698a982248b8409bbe169d0dbc663fa0 rdf:first sg:person.01306034711.29
    174 rdf:rest N6ab4cd567d71473c9eda4663081ce52b
    175 N6a9e59ac785e462b9e57029912994577 rdf:first N6209d11b53da479ea006a6f417c783b8
    176 rdf:rest Ndcc4d141dbfe42d5a132b9c09f869fb6
    177 N6ab4cd567d71473c9eda4663081ce52b rdf:first N4e9f2e27912543048ee4c0ea4ef3e52b
    178 rdf:rest N7d68f3b5dc79448699d6eba1f1eb4896
    179 N6e1390f0801344b0be613a5e4966b460 rdf:first sg:person.01044224567.27
    180 rdf:rest N068709681d884fcaa82e40fbaee64bc4
    181 N6ff44093d05944c8af06409ced8763d2 schema:name ††Health Research & Policy and Statistics, and
    182 rdf:type schema:Organization
    183 N70d18521679245649ed2b2e4c9fc949b schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    184 schema:familyName Yu
    185 schema:givenName Xin
    186 rdf:type schema:Person
    187 N7a73771c2d314df288eb9861027c4a45 rdf:first sg:person.01156610632.10
    188 rdf:rest N0494a90c05324743b8578366db27cef3
    189 N7a8a248155e847208367109a1099e848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Humans
    191 rdf:type schema:DefinedTerm
    192 N7d68f3b5dc79448699d6eba1f1eb4896 rdf:first Nd02a2396bea944349ffed67857d42556
    193 rdf:rest Nc85ca0ed63ad4fa293738595d4ec9fee
    194 N7fd8ed6dac674cf5a67081fad941481e rdf:first N26706ea310e84423b7f6b6bb5bbcff9d
    195 rdf:rest Ne3e173d010e84941b76cae60609fea33
    196 N83f7f7b7a7dc482c95a4f15d24ae14e5 schema:familyName Botstein
    197 schema:givenName David
    198 rdf:type schema:Person
    199 N8b8085dedf65446e8107349a67039f89 schema:name ¶¶Pathology,
    200 rdf:type schema:Organization
    201 N8d0f618bcfd1446f8b4006463ada95b1 rdf:first Nf8bdbe7146474c6599c2abf1c3220069
    202 rdf:rest N1efa572323be445ba24b402d99f87337
    203 N9406fde98fb24d83b5680c28dfebb7df schema:name #Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, Bethesda, Maryland 20892, USA
    204 rdf:type schema:Organization
    205 N95230f025f0a47d5824977c97cac6452 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    206 schema:familyName Tran
    207 schema:givenName Truc
    208 rdf:type schema:Person
    209 N967f9744b1c14b3ea8f7d528d971ce07 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    210 schema:familyName Grever
    211 schema:givenName Michael R.
    212 rdf:type schema:Person
    213 Na3afe44d90cd4f348845b4315e5656c1 schema:name Springer Nature - SN SciGraph project
    214 rdf:type schema:Organization
    215 Na3ce7655b542410ea7d58c58e7fefdc7 rdf:first sg:person.014304415612.51
    216 rdf:rest Nf87c6791a1bc46809cbbe1ac10eb11ab
    217 Na4933a27fa2d4640b82b260ec0d87493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Adult
    219 rdf:type schema:DefinedTerm
    220 Nb38ae1c36b844abc8c55955616db0d55 rdf:first sg:person.0617263730.50
    221 rdf:rest N63e1238f677149108adc978d15dccd3b
    222 Nb7133d941e6642f08e3c8cc21bd868c9 schema:affiliation Nc0621e4801df45df8a7bbb7413afe1e4
    223 schema:familyName Eisen
    224 schema:givenName Michael B.
    225 rdf:type schema:Person
    226 Nc0621e4801df45df8a7bbb7413afe1e4 schema:name ‖Genetics,
    227 rdf:type schema:Organization
    228 Nc1047ec0c5204c7e9be47e3be6d3d669 rdf:first sg:person.01352650472.55
    229 rdf:rest N7fd8ed6dac674cf5a67081fad941481e
    230 Nc3935899b44047dfbe42dfee1dfe642b rdf:first N70d18521679245649ed2b2e4c9fc949b
    231 rdf:rest N6e1390f0801344b0be613a5e4966b460
    232 Nc6701f5495a14403b848bb59e45de8d8 schema:name dimensions_id
    233 schema:value pub.1010898206
    234 rdf:type schema:PropertyValue
    235 Nc6d8395c31fd4916b47b362b5895403c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Oligonucleotide Array Sequence Analysis
    237 rdf:type schema:DefinedTerm
    238 Nc85ca0ed63ad4fa293738595d4ec9fee rdf:first sg:person.07764030507.12
    239 rdf:rest N24e1d89dacad4c88bf77b5a5a8d70631
    240 Nc8a249a3cf464939a032d28db6e7a534 schema:name #Bioinformatics and Molecular Analysis Section, CBEL, CIT, NIH, Bethesda, Maryland 20892, USA
    241 rdf:type schema:Organization
    242 Nc8e28face6b64ab58326157a3f7c8ac0 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
    243 schema:familyName Hudson
    244 schema:givenName James
    245 rdf:type schema:Person
    246 Nccd5be65eee3494cb563d38cc3b241da schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    247 schema:familyName Rosenwald
    248 schema:givenName Andreas
    249 rdf:type schema:Person
    250 Ncdf65a990d5849ac81cbe7cccc254d57 rdf:first sg:person.01147337213.04
    251 rdf:rest N3b9a4e1ce2e04492b1c19fb8d363e22e
    252 Nceaeea6d1da74abc8c2ea2ee28b6e350 schema:name doi
    253 schema:value 10.1038/35000501
    254 rdf:type schema:PropertyValue
    255 Ncffa1bbeba0c4edbbfca8e14d96c0bb2 schema:name *Departments of Biochemistry,
    256 rdf:type schema:Organization
    257 Nd02a2396bea944349ffed67857d42556 schema:affiliation N0e4652d165d14d16b93e738f6455c8fd
    258 schema:familyName Levy
    259 schema:givenName Ronald
    260 rdf:type schema:Person
    261 Nd0b081898c9d41ffa2b81951881f0568 rdf:first N0bf71260115b47eda7feba5e1baf7a63
    262 rdf:rest Nb38ae1c36b844abc8c55955616db0d55
    263 Nd47ccf5a0de54c75b3f3b66a733a17b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Leukemia, Lymphocytic, Chronic, B-Cell
    265 rdf:type schema:DefinedTerm
    266 Nd5c8052edff24d93ab75c40e02726acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    267 schema:name B-Lymphocytes
    268 rdf:type schema:DefinedTerm
    269 Ndbf8bd1c387245a586f00c66b699e317 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    270 schema:name Tumor Cells, Cultured
    271 rdf:type schema:DefinedTerm
    272 Ndcc4d141dbfe42d5a132b9c09f869fb6 rdf:first N83f7f7b7a7dc482c95a4f15d24ae14e5
    273 rdf:rest Na3ce7655b542410ea7d58c58e7fefdc7
    274 Ndcd68cf9267c4930a45884e556933d07 rdf:first N95230f025f0a47d5824977c97cac6452
    275 rdf:rest Nc3935899b44047dfbe42dfee1dfe642b
    276 Ne3e173d010e84941b76cae60609fea33 rdf:first Nc8e28face6b64ab58326157a3f7c8ac0
    277 rdf:rest N8d0f618bcfd1446f8b4006463ada95b1
    278 Ne898ab9d86b14c3f98641440f3e03966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    279 schema:name Phenotype
    280 rdf:type schema:DefinedTerm
    281 Ne953d79bc2d64e0f9d7a37ec30743095 schema:issueNumber 6769
    282 rdf:type schema:PublicationIssue
    283 Ned70f48c65ea48569e791aad3bc411e4 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    284 schema:familyName Davis
    285 schema:givenName R. Eric
    286 rdf:type schema:Person
    287 Nf3dae9b107384e99abec76fef2527450 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name Lymphoma, Large B-Cell, Diffuse
    289 rdf:type schema:DefinedTerm
    290 Nf87c6791a1bc46809cbbe1ac10eb11ab rdf:first sg:person.0750405002.26
    291 rdf:rest rdf:nil
    292 Nf8bdbe7146474c6599c2abf1c3220069 schema:affiliation N17132c1cd12f475b82a091ba958319d7
    293 schema:familyName Lu
    294 schema:givenName Lisheng
    295 rdf:type schema:Person
    296 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    297 schema:name Medical and Health Sciences
    298 rdf:type schema:DefinedTerm
    299 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    300 schema:name Oncology and Carcinogenesis
    301 rdf:type schema:DefinedTerm
    302 sg:grant.2715036 http://pending.schema.org/fundedItem sg:pub.10.1038/35000501
    303 rdf:type schema:MonetaryGrant
    304 sg:grant.2724456 http://pending.schema.org/fundedItem sg:pub.10.1038/35000501
    305 rdf:type schema:MonetaryGrant
    306 sg:journal.1018957 schema:issn 0090-0028
    307 1476-4687
    308 schema:name Nature
    309 rdf:type schema:Periodical
    310 sg:person.01044224567.27 schema:affiliation N9406fde98fb24d83b5680c28dfebb7df
    311 schema:familyName Powell
    312 schema:givenName John I.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044224567.27
    314 rdf:type schema:Person
    315 sg:person.01147337213.04 schema:affiliation Ncffa1bbeba0c4edbbfca8e14d96c0bb2
    316 schema:familyName Boldrick
    317 schema:givenName Jennifer C.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147337213.04
    319 rdf:type schema:Person
    320 sg:person.01156610632.10 schema:affiliation N0e68100d39cb4a0bacf019304ef5b218
    321 schema:familyName Lossos
    322 schema:givenName Izidore S.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156610632.10
    324 rdf:type schema:Person
    325 sg:person.012635177675.42 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    326 schema:familyName Sabet
    327 schema:givenName Hajeer
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012635177675.42
    329 rdf:type schema:Person
    330 sg:person.01306034711.29 schema:affiliation https://www.grid.ac/institutes/grid.266813.8
    331 schema:familyName Armitage
    332 schema:givenName James O.
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306034711.29
    334 rdf:type schema:Person
    335 sg:person.01350734042.58 schema:affiliation N4db48122c8e04b1db6e05a337ee9a416
    336 schema:familyName Alizadeh
    337 schema:givenName Ash A.
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350734042.58
    339 rdf:type schema:Person
    340 sg:person.01352650472.55 schema:affiliation https://www.grid.ac/institutes/grid.417587.8
    341 schema:familyName Marti
    342 schema:givenName Gerald E.
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352650472.55
    344 rdf:type schema:Person
    345 sg:person.014304415612.51 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    346 schema:familyName Brown
    347 schema:givenName Patrick O.
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014304415612.51
    349 rdf:type schema:Person
    350 sg:person.0617263730.50 schema:familyName Sherlock
    351 schema:givenName Gavin
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617263730.50
    353 rdf:type schema:Person
    354 sg:person.0750405002.26 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    355 schema:familyName Staudt
    356 schema:givenName Louis M.
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750405002.26
    358 rdf:type schema:Person
    359 sg:person.07764030507.12 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    360 schema:familyName Wilson
    361 schema:givenName Wyndham
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07764030507.12
    363 rdf:type schema:Person
    364 sg:pub.10.1023/a:1023293621057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035311070
    365 https://doi.org/10.1023/a:1023293621057
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1038/ng0697-161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047492526
    368 https://doi.org/10.1038/ng0697-161
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/ng1097-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001550579
    371 https://doi.org/10.1038/ng1097-226
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/ng1296-457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010987019
    374 https://doi.org/10.1038/ng1296-457
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/sj.leu.2401487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017462984
    377 https://doi.org/10.1038/sj.leu.2401487
    378 rdf:type schema:CreativeWork
    379 https://app.dimensions.ai/details/publication/pub.1079660171 schema:CreativeWork
    380 https://app.dimensions.ai/details/publication/pub.1082445528 schema:CreativeWork
    381 https://app.dimensions.ai/details/publication/pub.1082613112 schema:CreativeWork
    382 https://app.dimensions.ai/details/publication/pub.1082636329 schema:CreativeWork
    383 https://app.dimensions.ai/details/publication/pub.1082636330 schema:CreativeWork
    384 https://app.dimensions.ai/details/publication/pub.1082877384 schema:CreativeWork
    385 https://app.dimensions.ai/details/publication/pub.1082895244 schema:CreativeWork
    386 https://app.dimensions.ai/details/publication/pub.1083111437 schema:CreativeWork
    387 https://app.dimensions.ai/details/publication/pub.1083313190 schema:CreativeWork
    388 https://app.dimensions.ai/details/publication/pub.1083335823 schema:CreativeWork
    389 https://app.dimensions.ai/details/publication/pub.1083350334 schema:CreativeWork
    390 https://doi.org/10.1002/(sici)1096-9896(199606)179:2<145::aid-path565>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014370189
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/s0076-6879(99)03014-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040259960
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/s0378-1119(99)00035-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039207160
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/s0952-7915(98)80223-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049365667
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1056/nejm199304083281404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043239598
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1056/nejm199309303291402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013554742
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1073/pnas.89.15.6770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042706782
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1073/pnas.96.12.6745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033514193
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1073/pnas.96.16.9212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002392246
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1084/jem.186.3.439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049167524
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1084/jem.186.9.1547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438634
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1084/jem.188.9.1679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023876130
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1084/jem.188.9.1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051868501
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1084/jem.190.7.1025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018218908
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1084/jem.190.7.1033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025288591
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1093/jnci/91.20.1758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031623677
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1093/nar/23.12.2127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022776974
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1101/gad.12.17.2651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019160542
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1101/sqb.1999.64.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060415749
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1111/j.1600-065x.1998.tb01447.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053542093
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1126/science.270.5235.467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551475
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1126/science.275.5299.540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009053054
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1126/science.276.5312.589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014082032
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1126/science.286.5439.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042995627
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1172/jci115205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001362998
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1177/095952873201700106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063895540
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1200/jco.1996.14.7.2131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082907384
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.3109/08830189909088490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022411448
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.7326/0003-4819-127-3-199708010-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073701584
    449 rdf:type schema:CreativeWork
    450 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
    451 schema:name *Departments of Biochemistry,
    452 Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    453 rdf:type schema:Organization
    454 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    455 schema:name §§Johns Hopkins Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    456 rdf:type schema:Organization
    457 https://www.grid.ac/institutes/grid.266813.8 schema:alternateName University of Nebraska Medical Center
    458 schema:name ‡‡Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    459 rdf:type schema:Organization
    460 https://www.grid.ac/institutes/grid.414467.4 schema:alternateName Walter Reed National Military Medical Center
    461 schema:name ☆☆Walter Reed Army Medical Center , Washington, DC 20307, USA
    462 rdf:type schema:Organization
    463 https://www.grid.ac/institutes/grid.417587.8 schema:alternateName United States Food and Drug Administration
    464 schema:name §CBER, FDA, Bethesda, Maryland 20892, USA
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.418190.5 schema:alternateName Thermo Fisher Scientific (United States)
    467 schema:name ☆Research Genetics, Huntsville , Alabama 35801, USA
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
    470 schema:name ##Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    471 ∫Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    472 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...