The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-02

AUTHORS

A Cano, M A Pérez-Moreno, I Rodrigo, A Locascio, M J Blanco, M G del Barrio, F Portillo, M A Nieto

ABSTRACT

The Snail family of transcription factors has previously been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal transitions) during embryonic development. Epithelial-mesenchymal transitions are also determinants of the progression of carcinomas, occurring concomitantly with the cellular acquisition of migratory properties following downregulation of expression of the adhesion protein E-cadherin. Here we show that mouse Snail is a strong repressor of transcription of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a fibroblastoid phenotype and acquire tumorigenic and invasive properties. Endogenous Snail protein is present in invasive mouse and human carcinoma cell lines and tumours in which E-cadherin expression has been lost. Therefore, the same molecules are used to trigger epithelial-mesenchymal transitions during embryonic development and in tumour progression. Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs. More... »

PAGES

76-83

References to SciGraph publications

Journal

TITLE

Nature Cell Biology

ISSUE

2

VOLUME

2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35000025

DOI

http://dx.doi.org/10.1038/35000025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013092049

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10655586


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