Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-02

AUTHORS

P J Peters, J J Neefjes, V Oorschot, H L Ploegh, H J Geuze

ABSTRACT

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis. More... »

PAGES

669-676

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/349669a0

DOI

http://dx.doi.org/10.1038/349669a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017011701

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1847504


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