Cyclin is degraded by the ubiquitin pathway View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-01

AUTHORS

M Glotzer, A W Murray, M W Kirschner

ABSTRACT

Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates with ubiquitin. The kinetic properties of the conjugates indicate that cyclin is degraded by ubiquitin-dependent proteolysis. Thus anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system. More... »

PAGES

132-138

Journal

TITLE

Nature

ISSUE

6305

VOLUME

349

Related Patents

  • Screening Methods Involving The Detection Of Short-Lived Proteins
  • Human Ubiquitin Conjugating Enzyme
  • Vaccines With Enhanced Intracellular Processing
  • Assays For Compounds That Modulate Or Alter Cyclin E Activity
  • Deubiquitinating Enzyme: Compositions And Methods
  • Rapid Method Of Proteasome Purification Using Proteins Having Sequence Homology To Ubiquitin
  • Pyridopyrimidinone Inhibitors Of Kinases
  • Pyridopyrimidinone Inhibitors Of Kinases
  • Pyridazino [4, 5 -D] Pyrimidin- (6h) -One Inhibitors Of Wee - 1 Kinase
  • Human Cyclin E
  • Cell Cycle Checkpoint Genes
  • Human Cyclin E Polypeptides
  • Methods And Compositions For Rapid Purification Of Proteasomes And Methods Of Use Of Components Thereof
  • Pyridazino[4,5-D]Pyrimidin-5(6h)-One Inhibitors Of Kinases
  • Pyridazino[4,5-D]Pyrimidin-5(6h)-One Inhibitors Of Kinases
  • Α-Ketoamide Multicatalytic Protease Inhibitors
  • Immunoassays For Human Cyclin E
  • Α-Ketoamide Inhibitors Of 20s Proteasome
  • Ubiquitin Conjugating Enzymes
  • Cell Cycle-Regulating Proteins
  • Α-Ketoamide Multicatalytic Protease Inhibitors
  • Methods And Compositions For Rapid Purification Of Proteasomes And Methods Of Use Of Components Thereof
  • Screening Methods Involving The Detection Of Short-Lived Proteins
  • Components Of Ubiquitin Ligase Complexes, And Uses Related Thereto
  • Alpha-Ketoamide Inhibitors Of 20s Proteasome
  • Geminin Gene And Protein
  • Assay And Reagents For Detecting Inhibitors Of Ubiquitin-Dependent Degradation Of Cell Cycle Regulatory Proteins
  • Ubiquitin Conjugating Enzymes
  • Ubiquitin Ligases, And Uses Related Thereto
  • Cell Cycle Checkpoint Genes
  • Tricyclic Inhibitors Of Kinases
  • Screening Methods Involving The Detection Of Short-Lived Proteins
  • Pyridopyrimidinone Inhibitors Of Kinases
  • Pyridopyrimidinone Inhibitors Of Kinases
  • Screening Methods Involving The Detection Of Short-Lived Proteins
  • Method Of Treating A Chemically Sensitive Individual
  • Chemical Entities To Be Used For Wee1 Inhibition For The Treatment Of Cancer
  • Human Cyclin E
  • Tricyclic Inhibitors Of Kinases
  • Ubiquitin Conjugating Enzymes
  • Tricyclic Inhibitors Of Kinases Useful For The Treatment Of Proliferative Diseases
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/349132a0

    DOI

    http://dx.doi.org/10.1038/349132a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013684407

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1846030


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cloning, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kinetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenopus", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, San Francisco", 
              "id": "https://www.grid.ac/institutes/grid.266102.1", 
              "name": [
                "Department of Biochemistry, School of Medicine, University of California, San Francisco 94143-0448."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glotzer", 
            "givenName": "M", 
            "id": "sg:person.01230255466.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230255466.01"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Murray", 
            "givenName": "A W", 
            "id": "sg:person.01120156055.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120156055.27"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Kirschner", 
            "givenName": "M W", 
            "id": "sg:person.010060707017.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010060707017.86"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1073/pnas.86.16.6255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000299844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/329131a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000508335", 
              "https://doi.org/10.1038/329131a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/329131a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000508335", 
              "https://doi.org/10.1038/329131a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/339275a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001389085", 
              "https://doi.org/10.1038/339275a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90504-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004099385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(88)90529-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006706971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90628-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007079466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/346379a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007404861", 
              "https://doi.org/10.1038/346379a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.108.4.1431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013195731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(90)90161-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015290510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(90)90161-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015290510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.2.359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015330296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90629-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016235258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.98.4.1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019252484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/342512a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020411965", 
              "https://doi.org/10.1038/342512a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(89)90180-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020489189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(89)90180-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020489189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90936-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020835074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/343555a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022183391", 
              "https://doi.org/10.1038/343555a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(81)90357-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022779334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.77.1.462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024783655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.2.488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026991187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cb.03.110187.000245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027857841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.109.5.1895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030058624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.56.070187.002001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030260543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(83)90420-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031726071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90165-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033703436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0378-1119(87)90165-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033703436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90635-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034645816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90481-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035757503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/344503a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036849203", 
              "https://doi.org/10.1038/344503a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.39.070170.004433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038558781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90801-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039584353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(84)90299-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040894247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90535-m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042681061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/346760a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042858506", 
              "https://doi.org/10.1038/346760a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/338438a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044703502", 
              "https://doi.org/10.1038/338438a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/339280a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048440605", 
              "https://doi.org/10.1038/339280a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/338394a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048837529", 
              "https://doi.org/10.1038/338394a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2538923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062542766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2842867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062565723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3018930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062582889"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1991-01", 
        "datePublishedReg": "1991-01-01", 
        "description": "Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates with ubiquitin. The kinetic properties of the conjugates indicate that cyclin is degraded by ubiquitin-dependent proteolysis. Thus anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/349132a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6305", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "349"
          }
        ], 
        "name": "Cyclin is degraded by the ubiquitin pathway", 
        "pagination": "132-138", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "413095ede801999d8b72cfadcc8531373747f292826aca009210c3906900007e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "1846030"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/349132a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1013684407"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/349132a0", 
          "https://app.dimensions.ai/details/publication/pub.1013684407"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nature/journal/v349/n6305/full/349132a0.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/349132a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/349132a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/349132a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/349132a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    241 TRIPLES      21 PREDICATES      76 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/349132a0 schema:about N255e943690b9476a8b3163ec1d28ebe6
    2 N3b748acaee3745b7ae84d51e1089d470
    3 N503373f254954025a016014adbd7ed85
    4 N57d6cbd4b889453e8d81256134caea63
    5 N6f7d8f4186604276bcaf9d4e8161c0a3
    6 Nbf063083fd544d518ef1f1ab318eb767
    7 Nd61d653346d84fa29753bd6ca85e4dea
    8 Ned96bc33b9b44043bc8a354ab9d3c8ea
    9 Nf51f537820544784baed10ff30a17904
    10 anzsrc-for:06
    11 anzsrc-for:0601
    12 schema:author N360efab48fd74434b32159c0888111a4
    13 schema:citation sg:pub.10.1038/329131a0
    14 sg:pub.10.1038/338394a0
    15 sg:pub.10.1038/338438a0
    16 sg:pub.10.1038/339275a0
    17 sg:pub.10.1038/339280a0
    18 sg:pub.10.1038/342512a0
    19 sg:pub.10.1038/343555a0
    20 sg:pub.10.1038/344503a0
    21 sg:pub.10.1038/346379a0
    22 sg:pub.10.1038/346760a0
    23 https://doi.org/10.1016/0092-8674(81)90357-3
    24 https://doi.org/10.1016/0092-8674(83)90420-8
    25 https://doi.org/10.1016/0092-8674(84)90299-x
    26 https://doi.org/10.1016/0092-8674(86)90801-9
    27 https://doi.org/10.1016/0092-8674(88)90529-6
    28 https://doi.org/10.1016/0092-8674(89)90628-4
    29 https://doi.org/10.1016/0092-8674(89)90629-6
    30 https://doi.org/10.1016/0092-8674(89)90635-1
    31 https://doi.org/10.1016/0092-8674(89)90936-7
    32 https://doi.org/10.1016/0092-8674(90)90481-s
    33 https://doi.org/10.1016/0092-8674(90)90504-8
    34 https://doi.org/10.1016/0092-8674(90)90535-m
    35 https://doi.org/10.1016/0378-1119(87)90165-x
    36 https://doi.org/10.1016/0968-0004(89)90180-1
    37 https://doi.org/10.1016/0968-0004(90)90161-4
    38 https://doi.org/10.1073/pnas.77.1.462
    39 https://doi.org/10.1073/pnas.82.2.488
    40 https://doi.org/10.1073/pnas.84.2.359
    41 https://doi.org/10.1073/pnas.86.16.6255
    42 https://doi.org/10.1083/jcb.108.4.1431
    43 https://doi.org/10.1083/jcb.109.5.1895
    44 https://doi.org/10.1083/jcb.98.4.1247
    45 https://doi.org/10.1126/science.2538923
    46 https://doi.org/10.1126/science.2842867
    47 https://doi.org/10.1126/science.3018930
    48 https://doi.org/10.1146/annurev.bi.39.070170.004433
    49 https://doi.org/10.1146/annurev.bi.56.070187.002001
    50 https://doi.org/10.1146/annurev.cb.03.110187.000245
    51 schema:datePublished 1991-01
    52 schema:datePublishedReg 1991-01-01
    53 schema:description Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates with ubiquitin. The kinetic properties of the conjugates indicate that cyclin is degraded by ubiquitin-dependent proteolysis. Thus anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system.
    54 schema:genre research_article
    55 schema:inLanguage en
    56 schema:isAccessibleForFree false
    57 schema:isPartOf N039fe8fb9e6141e4aa9c3ae5dcc26643
    58 N2d44863056324b03af51d5bd2177e9bd
    59 sg:journal.1018957
    60 schema:name Cyclin is degraded by the ubiquitin pathway
    61 schema:pagination 132-138
    62 schema:productId N0a70cc3fd6b64b298c21580d0c759371
    63 N7fb54c1e36524337a795585c1b3bd9fe
    64 Nc28ef00ade7c4678be94fea5c9a0ba34
    65 Ndfb31255b8b3452798bd694395dd3887
    66 Nfe2bdaff652f4ec7888290a71a77858f
    67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013684407
    68 https://doi.org/10.1038/349132a0
    69 schema:sdDatePublished 2019-04-11T00:54
    70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    71 schema:sdPublisher N99bbbe656413444fbadfdcadb62e525e
    72 schema:url http://www.nature.com/nature/journal/v349/n6305/full/349132a0.html
    73 sgo:license sg:explorer/license/
    74 sgo:sdDataset articles
    75 rdf:type schema:ScholarlyArticle
    76 N039fe8fb9e6141e4aa9c3ae5dcc26643 schema:issueNumber 6305
    77 rdf:type schema:PublicationIssue
    78 N0a70cc3fd6b64b298c21580d0c759371 schema:name dimensions_id
    79 schema:value pub.1013684407
    80 rdf:type schema:PropertyValue
    81 N255e943690b9476a8b3163ec1d28ebe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name Molecular Sequence Data
    83 rdf:type schema:DefinedTerm
    84 N2d44863056324b03af51d5bd2177e9bd schema:volumeNumber 349
    85 rdf:type schema:PublicationVolume
    86 N360efab48fd74434b32159c0888111a4 rdf:first sg:person.01230255466.01
    87 rdf:rest N9be3d3d6632e4fb082d9690820d4a56e
    88 N3b748acaee3745b7ae84d51e1089d470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Xenopus
    90 rdf:type schema:DefinedTerm
    91 N503373f254954025a016014adbd7ed85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Kinetics
    93 rdf:type schema:DefinedTerm
    94 N57d6cbd4b889453e8d81256134caea63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Cloning, Molecular
    96 rdf:type schema:DefinedTerm
    97 N6e3c04c948f54f01a29c9c117c79dcb5 rdf:first sg:person.010060707017.86
    98 rdf:rest rdf:nil
    99 N6f7d8f4186604276bcaf9d4e8161c0a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Animals
    101 rdf:type schema:DefinedTerm
    102 N7fb54c1e36524337a795585c1b3bd9fe schema:name pubmed_id
    103 schema:value 1846030
    104 rdf:type schema:PropertyValue
    105 N99bbbe656413444fbadfdcadb62e525e schema:name Springer Nature - SN SciGraph project
    106 rdf:type schema:Organization
    107 N9be3d3d6632e4fb082d9690820d4a56e rdf:first sg:person.01120156055.27
    108 rdf:rest N6e3c04c948f54f01a29c9c117c79dcb5
    109 Nbf063083fd544d518ef1f1ab318eb767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name RNA, Messenger
    111 rdf:type schema:DefinedTerm
    112 Nc28ef00ade7c4678be94fea5c9a0ba34 schema:name nlm_unique_id
    113 schema:value 0410462
    114 rdf:type schema:PropertyValue
    115 Nd61d653346d84fa29753bd6ca85e4dea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Amino Acid Sequence
    117 rdf:type schema:DefinedTerm
    118 Ndfb31255b8b3452798bd694395dd3887 schema:name readcube_id
    119 schema:value 413095ede801999d8b72cfadcc8531373747f292826aca009210c3906900007e
    120 rdf:type schema:PropertyValue
    121 Ned96bc33b9b44043bc8a354ab9d3c8ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Cyclins
    123 rdf:type schema:DefinedTerm
    124 Nf51f537820544784baed10ff30a17904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Ubiquitins
    126 rdf:type schema:DefinedTerm
    127 Nfe2bdaff652f4ec7888290a71a77858f schema:name doi
    128 schema:value 10.1038/349132a0
    129 rdf:type schema:PropertyValue
    130 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Biological Sciences
    132 rdf:type schema:DefinedTerm
    133 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Biochemistry and Cell Biology
    135 rdf:type schema:DefinedTerm
    136 sg:journal.1018957 schema:issn 0090-0028
    137 1476-4687
    138 schema:name Nature
    139 rdf:type schema:Periodical
    140 sg:person.010060707017.86 schema:familyName Kirschner
    141 schema:givenName M W
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010060707017.86
    143 rdf:type schema:Person
    144 sg:person.01120156055.27 schema:familyName Murray
    145 schema:givenName A W
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120156055.27
    147 rdf:type schema:Person
    148 sg:person.01230255466.01 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
    149 schema:familyName Glotzer
    150 schema:givenName M
    151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230255466.01
    152 rdf:type schema:Person
    153 sg:pub.10.1038/329131a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000508335
    154 https://doi.org/10.1038/329131a0
    155 rdf:type schema:CreativeWork
    156 sg:pub.10.1038/338394a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048837529
    157 https://doi.org/10.1038/338394a0
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/338438a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044703502
    160 https://doi.org/10.1038/338438a0
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1038/339275a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001389085
    163 https://doi.org/10.1038/339275a0
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/339280a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048440605
    166 https://doi.org/10.1038/339280a0
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1038/342512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020411965
    169 https://doi.org/10.1038/342512a0
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1038/343555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022183391
    172 https://doi.org/10.1038/343555a0
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/344503a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036849203
    175 https://doi.org/10.1038/344503a0
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/346379a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007404861
    178 https://doi.org/10.1038/346379a0
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/346760a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042858506
    181 https://doi.org/10.1038/346760a0
    182 rdf:type schema:CreativeWork
    183 https://doi.org/10.1016/0092-8674(81)90357-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022779334
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1016/0092-8674(83)90420-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031726071
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/0092-8674(84)90299-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040894247
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/0092-8674(86)90801-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039584353
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/0092-8674(88)90529-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006706971
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/0092-8674(89)90628-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007079466
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/0092-8674(89)90629-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016235258
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1016/0092-8674(89)90635-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034645816
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1016/0092-8674(89)90936-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020835074
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1016/0092-8674(90)90481-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1035757503
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1016/0092-8674(90)90504-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004099385
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/0092-8674(90)90535-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1042681061
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/0378-1119(87)90165-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033703436
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/0968-0004(89)90180-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020489189
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/0968-0004(90)90161-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015290510
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1073/pnas.77.1.462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024783655
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1073/pnas.82.2.488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026991187
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1073/pnas.84.2.359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015330296
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1073/pnas.86.16.6255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000299844
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1083/jcb.108.4.1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013195731
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1083/jcb.109.5.1895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030058624
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1083/jcb.98.4.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019252484
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1126/science.2538923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542766
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1126/science.2842867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565723
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1126/science.3018930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062582889
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1146/annurev.bi.39.070170.004433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038558781
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1146/annurev.bi.56.070187.002001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030260543
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1146/annurev.cb.03.110187.000245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027857841
    238 rdf:type schema:CreativeWork
    239 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
    240 schema:name Department of Biochemistry, School of Medicine, University of California, San Francisco 94143-0448.
    241 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...