Cyclin is degraded by the ubiquitin pathway View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-01

AUTHORS

Michael Glotzer, Andrew W. Murray, Marc W. Kirschner

ABSTRACT

Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle. When a region in the N terminus of cyclin is fused to a foreign protein, it produces a hybrid protein susceptible to proteolysis at mitosis. During the course of degradation, both cyclin and the hybrid form conjugates with ubiquitin. The kinetic properties of the conjugates indicate that cyclin is degraded by ubiquitin-dependent proteolysis. Thus anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system. More... »

PAGES

132-138

Journal

TITLE

Nature

ISSUE

6305

VOLUME

349

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/349132a0

    DOI

    http://dx.doi.org/10.1038/349132a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013684407

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1846030


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