The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-01

AUTHORS

D P Barlow, R Stöger, B G Herrmann, K Saito, N Schweifer

ABSTRACT

T-associated maternal effect (Tme) is the only known maternal-effect mutation in the mouse. The defect is nuclear-encoded and embryos that inherit a deletion of the Tme locus from their mother die at day 15 of gestation. There are many genomically imprinted regions known in the mouse genome but so far no imprinted genes have been cloned. The Tme locus is absent in two chromosome-17 deletion mutants, Thp and the tLub2, and its position has been localized using these deletions to a 1-cM region. We report here that the genes for insulin-like growth factor type-2 receptor (Igf2r) and mitochondrial superoxide dismutase-2 (Sod-2) are absent from both deletions. Probes for these genes and for plasminogen (Plg) and T-complex peptide 1 (Tcp-1) were used in pulsed-field gel mapping to show that Tme must lie within a region of 800-1,100 kb. We also demonstrate that embryos express Igf2r only from the maternal chromosome, and that Tcp-1, Plg and Sod-2 are expressed from both chromosomes. Therefore Igf2r is imprinted and closely linked or identical to Tme. More... »

PAGES

84-87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/349084a0

DOI

http://dx.doi.org/10.1038/349084a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036969301

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1845916


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