A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-01

AUTHORS

C J Brown, A Ballabio, J L Rupert, R G Lafreniere, M Grompe, R Tonlorenzi, H F Willard

ABSTRACT

X-chromosome inactivation results in the cis-limited dosage compensation of genes on one of the pair of X chromosomes in mammalian females. Although most X-linked genes are believed to be subject to inactivation, several are known to be expressed from both active and inactive X chromosomes. Here we describe an X-linked gene with a novel expression pattern--transcripts are detected only from the inactive X chromosome (Xi) and not from the active X chromosome (Xa). This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation. More... »

PAGES

38-44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/349038a0

DOI

http://dx.doi.org/10.1038/349038a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053275082

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1985261


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