Ontology type: schema:ScholarlyArticle
1990-12
AUTHORSThomas Spies, Maureen Bresnahan, Seiamak Bahrain, Daniele Arnold, George Blanck, Elizabeth Mellins, Donald Pious, Robert DeMars
ABSTRACTMAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4–6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides. More... »
PAGES744-747
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DOIhttp://dx.doi.org/10.1038/348744a0
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