A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

Thomas Spies, Maureen Bresnahan, Seiamak Bahrain, Daniele Arnold, George Blanck, Elizabeth Mellins, Donald Pious, Robert DeMars

ABSTRACT

MAJOR histocompatibility complex (MHC) class I molecules export peptides to the cell surface for surveillance by cytotoxic T lymphocytes1-3. Intracellular peptide binding is critical for the proper assembly and transport of class I molecules4–6. This mechanism is impaired as a result of a non-functional peptide supply factor gene (PSF) in several human mutant cell lines with genomic lesions in the MHC. We have now identified PSF in the MHC class II region by deletion mapping in mutants and chromosome-walking. PSF is homologous to mammalian and bacterial ATP-dependent transport proteins, suggesting that it operates in the intracellular transport of peptides. More... »

PAGES

744-747

Journal

TITLE

Nature

ISSUE

6303

VOLUME

348

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  • Antigen Processing
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/348744a0

    DOI

    http://dx.doi.org/10.1038/348744a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014832159

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2259384


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