Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

J Trowsdale, I Hanson, I Mockridge, S Beck, A Townsend, A Kelly

ABSTRACT

Class I molecules of the major histocompatibility complex (MHC) bind and present peptides derived from the degradation of intracellular, often cytoplasmic, proteins, whereas class II molecules usually present proteins from the extracellular environment. It is not known how peptides derived from cytoplasmic proteins cross a membrane before presentation at the cell surface. But certain mutations in the MHC can prevent presentation of antigens with class I molecules. In addition, mutations possibly in the MHC can affect presentation by class II molecules. Here we report the finding of a new gene in the MHC that might have a role in antigen presentation and which is related to the ABC (ATP-binding cassette) superfamily of transporters. This superfamily includes the human multidrug-resistance protein, and a series of transporters from bacteria and eukaryotic cells capable of transporting a range of substrates, including peptides. More... »

PAGES

741-744

Journal

TITLE

Nature

ISSUE

6303

VOLUME

348

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/348741a0

    DOI

    http://dx.doi.org/10.1038/348741a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022002059

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2259383


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