Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-12

AUTHORS

H te Riele, E R Maandag, A Clarke, M Hooper, A Berns

ABSTRACT

Specific genes can be inactivated or mutated in the mouse germ line. The phenotypic consequences of the mutation can provide pivotal information on the function of the gene in development and maintenance of the mammalian organism. The procedure entails homologous recombination in embryonic stem cells, which, on fusion to recipient blastocysts, give rise to chimaeric mice that can transmit the mutant gene to their offspring. Inbreeding can then yield mice carrying the mutation in both alleles allowing the phenotypic analysis of recessive mutations. In addition to mice lacking a particular gene function, cell lines carrying null alleles of normally expressed genes can be instrumental in assessing the function of the gene. These cell lines can either be obtained from homozygous animals or, should the mutation be lethal early in embryonic development, be generated by consecutive inactivation of both alleles by homologous recombination in cultured cells. Here we illustrate the feasibility of this latter approach by the efficient consecutive inactivation of both alleles of the pim-1 proto-oncogene in embryonic stem cells. More... »

PAGES

649-651

Journal

TITLE

Nature

ISSUE

6302

VOLUME

348

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/348649a0

    DOI

    http://dx.doi.org/10.1038/348649a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035885698

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2250720


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