Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-11

AUTHORS

D Hockenbery, G Nuñez, C Milliman, R D Schreiber, S J Korsmeyer

ABSTRACT

The t(14; 18) chromosomal translocation of human follicular B-cell lymphoma juxtaposes the bcl-2 gene with the immunoglobulin heavy chain locus. The bcl-2 immunoglobulin fusion gene is markedly deregulated resulting in inappropriately elevated levels of bcl-2 RNA and protein. Transgenic mice bearing a bcl-2 immunoglobulin minigene demonstrate a polyclonal expansion of resting yet responsive IgM-IgD B cells which display prolonged cell survival but no increase in cell cycling. Moreover, deregulated bcl-2 extends the survival of certain haematopoietic cell lines following growth-factor deprivation. By using immunolocalization studies we now demonstrate that Bcl-2 is an integral inner mitochondrial membrane protein of relative molecular mass 25,000 (25k). Overexpression of Bcl-2 blocks the apoptotic death of a pro-B-lymphocyte cell line. Thus, Bcl-2 is unique among proto-oncogenes, being localized to mitochondria and interfering with programmed cell death independent of promoting cell division. More... »

PAGES

334-336

Journal

TITLE

Nature

ISSUE

6299

VOLUME

348

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/348334a0

    DOI

    http://dx.doi.org/10.1038/348334a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005542034

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2250705


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