Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

A Simeone, D Acampora, L Arcioni, P W Andrews, E Boncinelli, F Mavilio

ABSTRACT

RETINOIC acid had been implicated as a natural morphogen in chicken and frog embryogenesis, and is presumed to act through the gene regulatory activity of a family of nuclear receptors. Homeobox genes, which specify positional information in Drosophila and possibly in vertebrate embryogenesis, are among the candidate responsive genes. We previously reported that retinoic acid specifically induces human homeobox gene (HOX) expression in the embryonal carcinoma cell line NT2/D1. We now show that the nine genes of the HOX2 cluster are differentially activated in NT2/D1 cells exposed to retinoic acid concentrations ranging from 10(-8) to 10(-5) M. Genes located in the 3' half of the cluster are induced at peak levels by 10(-8) M retinoic acid, whereas a concentration of 10(-6) to 10(-5) M is required to fully activate 5' genes. At both high and low retinoic acid concentrations, HOX2 genes are sequentially activated in embryonal carcinoma cells in the 3' to 5' direction. More... »

PAGES

763-766

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/346763a0

DOI

http://dx.doi.org/10.1038/346763a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007803553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1975088


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