Stimulation of p21ras upon T-cell activation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

J Downward, J D Graves, P H Warne, S Rayter, D A Cantrell

ABSTRACT

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C. More... »

PAGES

719-723

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/346719a0

DOI

http://dx.doi.org/10.1038/346719a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012664090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2201921


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