Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

T Tsurimoto, T Melendy, B Stillman

ABSTRACT

Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified components. DNA polymerase alpha-primase complex first initiates DNA synthesis at the replication origin and continues as the lagging strand polymerase. Subsequently, the DNA polymerase delta complex initiates replication on the leading strand template. Some prokaryotic DNA polymerase complexes can replace the eukaryotic polymerase delta complex. A model for polymerase switching during initiation of DNA replication is presented. More... »

PAGES

534-539

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/346534a0

DOI

http://dx.doi.org/10.1038/346534a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032196736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2165567


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