Empty MHC class I molecules come out in the cold View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1990-08

AUTHORS

Hans-Gustaf Ljunggren, Nico J. Stam, Claes Öhlén, Jacques J. Neefjes, Petter Höglund, Marie-Thérèse Heemels, Judy Bastin, Ton N. M. Schumacher, Alain Townsend, Klas Kärre, Hidde L. Ploegh

ABSTRACT

Major histocompatibility complex (MHC) class I molecules present antigen by transporting peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T cells. Recent work suggests that peptide binding may be required for efficient assembly and intracellular transport of MHC class I molecules, but it is not clear whether class I molecules can ever assemble in the absence of peptide. We report here that culture of the murine lymphoma mutant cell line RMA-S at reduced temperature (19-33 degrees C) promotes assembly, and results in a high level of cell surface expression of H-2/beta 2-microglobulin complexes that do not present endogenous antigens, and are labile at 37 degrees C. They can be stabilized at 37 degrees C by exposure to specific peptides known to interact with H-2Kb or Db. Our findings suggest that, in the absence of peptides, class I molecules can assemble but are unstable at body temperature. The induction of such molecules at reduced temperature opens new ways to analyse the nature of MHC class I peptide interactions at the cell surface. More... »

PAGES

476-480

Journal

TITLE

Nature

ISSUE

6283

VOLUME

346

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/346476a0

    DOI

    http://dx.doi.org/10.1038/346476a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021951190

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2198471


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