A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-07

AUTHORS

A H Sinclair, P Berta, M S Palmer, J R Hawkins, B L Griffiths, M J Smith, J W Foster, A M Frischauf, R Lovell-Badge, P N Goodfellow

ABSTRACT

A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF. More... »

PAGES

240-244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/346240a0

DOI

http://dx.doi.org/10.1038/346240a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041191003

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1695712


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